Sensor system for non-invasive optical carboxy-and methemoglobin determination

Timm, U.; Gewiss, Helge; Kraitl, J.; Brock, Beate; Ewald, Hartmut

doi:10.1117/12.2252549

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“…After approval by the Local Animal Ethics Committee (LALLF 7221.3-1-007/15; date of permission 31 March of 2015) an animal model was developed to evaluate a new multi wave sensor for reliable detection of hypoxia and dyshemoglobins [8].…”

Section: Methodsmentioning

confidence: 99%

O-Toluidine in Breath-Non-Invasive Prilocaine Monitoring

Brock¹,

Kamysek²,

Trefz³

et al. 2017

Clin Exp Pharmacol

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The generation of methaemoglobin is a rare but potential life-threatening side effect in the use of the local anaesthetic prilocaine. It is currently only possible to ensure the diagnosis by means of blood tests. Rapid noninvasive diagnosis is desirable, especially for risk patients.Using a pig model, we induced methaemoglobinemia via application of dimethyl aminophenol and prilocaine (setup I) or natrium nitrite and prilocaine (setup II). Continuous real time breath gas monitoring was performed by proton transfer reaction-time-of-flight-mass spectrometry (PTR-TOF-MS) for non-invasive determination of volatile organic compounds (VOCs).O-Toluidine, the main metabolite of prilocaine, could be detected in alveolar breath gas by means of PTR-TOF-MS and was confirmed by NTME-GC-MS (needle trap micro-extraction gas chromatography-mass spectrometry). The administration of prilocaine intravenously was clearly reflected with a time lag of a few min by the detection of O-Toluidine in the respiratory gas.If reliable correlations between prilocaine and methaemoglobin concentrations in blood and O-Toluidine levels in breath can be established, detection of prilocaine induced methaemoglobinemia and prevention of prilocaine poisoning with potentially life threatening hypoxia might be possible by means of non-invasive O-Toluidine analysis in breath.

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Section: Methodsmentioning

confidence: 99%