Sensorimotor effects of pergolide, a dopamine agonist, in healthy subjects: a lateralized readiness potential study

Rammsayer, Thomas; Stähl, Jutta

doi:10.1007/s00213-006-0400-9

Cited by 14 publications

(12 citation statements)

References 73 publications

(97 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Together with a correlation of increased omission errors with larger motor PINV’ amplitudes [36], these findings suggest that reduced attention may be associated with reduced iMP’ (less motor preparation) but increased mPINV’ (compensatory post-processing). Additionally, we hypothesized to find stimulant effects, which would specifically affect mPINV’ but not iMP’ amplitude (because dopaminergic medication in previous studies affected only lateralized post-movement potentials [31], [32]), pointing to medication-related compensation processes.…”

Section: Introductionmentioning

confidence: 99%

“…MRP could reflect an excellent neurophysiological marker to monitor the effects of stimulant medication in ADHD [29], [30]. During movement execution, lateralized MRP amplitudes (iMP’) seem rather independent of dopaminergic medication [31], [32]. In contrast, mPINV amplitude has been found to be affected by first generation antipsychotics (dopamine antagonists) [33].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of Stimulant Medication and Response Speed on Lateralization of Movement-Related Potentials in Attention-Deficit/Hyperactivity Disorder

Bender¹,

Resch

Klein

et al. 2012

PLoS ONE

View full text Add to dashboard Cite

Background Hyperactivity is one of the core symptoms in attention deficit hyperactivity disorder (ADHD). However, it remains unclear in which way the motor system itself and its development are affected by the disorder. Movement-related potentials (MRP) can separate different stages of movement execution, from the programming of a movement to motor post-processing and memory traces. Pre-movement MRP are absent or positive during early childhood and display a developmental increase of negativity. Methods We examined the influences of response-speed, an indicator of the level of attention, and stimulant medication on lateralized MRP in 16 children with combined type ADHD compared to 20 matched healthy controls. Results We detected a significantly diminished lateralisation of MRP over the pre-motor and primary motor cortex during movement execution (initial motor potential peak, iMP) in patients with ADHD. Fast reactions (indicating increased visuo-motor attention) led to increased lateralized negativity during movement execution only in healthy controls, while in children with ADHD faster reaction times were associated with more positive amplitudes. Even though stimulant medication had some effect on attenuating group differences in lateralized MRP, this effect was insufficient to normalize lateralized iMP amplitudes. Conclusions A reduced focal (lateralized) motor cortex activation during the command to muscle contraction points towards an immature motor system and a maturation delay of the (pre-) motor cortex in children with ADHD. A delayed maturation of the neuronal circuitry, which involves primary motor cortex, may contribute to ADHD pathophysiology.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of Stimulant Medication and Response Speed on Lateralization of Movement-Related Potentials in Attention-Deficit/Hyperactivity Disorder

Bender¹,

Resch

Klein

et al. 2012

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Shorter subsecond time-interval timing, however, appears to be more specifically modulated by dopaminergic activity (Rammsayer & Stahl 2006).…”

Section: Psychostimulants and Effects On Timingmentioning

confidence: 99%

“…Given the evidence for dopamine involvement in subsecond time discrimination (Rammsayer 1993;Rammsayer & Stahl 2006), we used a discrimination task of temporal differences of hundreds of milliseconds which has shown to elicit deficits in ADHD children (Smith et al 2002;Rubia et al 2007a). The task activates key timing regions of right dorsolateral and inferior prefrontal cortices, the cerebellum, ACG and the SMA in adults and children (Smith et al 2003, and elicits underactivation in ADHD adolescents in right lateral prefrontal cortex, ACG and SMA ( §3; figure 1b; Smith et al 2008).…”

Section: New Data: Effects Of Mph On Brain Dysfunction In Adhd Duringmentioning

confidence: 99%

Impulsiveness as a timing disturbance: neurocognitive abnormalities in attention-deficit hyperactivity disorder during temporal processes and normalization with methylphenidate

Rubia

Halari

Christakou

et al. 2009

Phil. Trans. R. Soc. B

279

282

View full text Add to dashboard Cite

We argue that impulsiveness is characterized by compromised timing functions such as premature motor timing, decreased tolerance to delays, poor temporal foresight and steeper temporal discounting. A model illustration for the association between impulsiveness and timing deficits is the impulsiveness disorder of attention-deficit hyperactivity disorder (ADHD). Children with ADHD have deficits in timing processes of several temporal domains and the neural substrates of these compromised timing functions are strikingly similar to the neuropathology of ADHD. We review our published and present novel functional magnetic resonance imaging data to demonstrate that ADHD children show dysfunctions in key timing regions of prefrontal, cingulate, striatal and cerebellar location during temporal processes of several time domains including time discrimination of milliseconds, motor timing to seconds and temporal discounting of longer time intervals. Given that impulsiveness, timing abnormalities and more specifically ADHD have been related to dopamine dysregulation, we tested for and demonstrated a normalization effect of all brain dysfunctions in ADHD children during time discrimination with the dopamine agonist and treatment of choice, methylphenidate. This review together with the new empirical findings demonstrates that neurocognitive dysfunctions in temporal processes are crucial to the impulsiveness disorder of ADHD and provides first evidence for normalization with a dopamine reuptake inhibitor.

show abstract

“…Furthermore, Rammsayer and Stahl [58] found that dopamine agonists facilitated early cognitive and perceptual aspects of sensorimotor processing such that the time required for early stimulus processing was reduced.…”

Section: Generalizability To Other Domainsmentioning

confidence: 99%

Age-related slowing of movement as basal ganglia dysfunction

Saling

Phillips

2008

Eur Rev Aging Phys Act

View full text Add to dashboard Cite

Attributions of age-related deficits in motor function to structural changes are compromised once the elderly exhibit lower error rates. This is because performance decrements observed in older adults are attributed to inferred strategic preferences for accuracy over speed. To understand genuine age differences in performance, we argue in the following theoretical paper that research needs to resolve methodological shortcomings and account for them within theoretical models of aging. Accounts of aging need to directly manipulate or control strategic differences in performance while assessing structural deficits. When this is done, age-related changes in motor control resemble the intermittencies of control seen in basal ganglia disorders. Given homologous circuitry in the basal ganglia, such observations could generalize to age-related changes in cognitive and emotional processes.Keywords Aging . Slowing of performance . Strategy . Basal ganglia . Performance operating characteristics Psychomotor function is a major contributor to the independence of older adults. Unfortunately, accounts of psychomotor change with age are complicated by difficulties in unequivocally addressing age-related change. Although gerontologists may wish to identify real structural deficits that can account for the behavior of older adults, the ability to address these deficits is limited by the ability to draw inferences from observable behaviors in the light of potential strategic variation [13,14,15,19,31,75]. By structural changes, we mean physiological changes associated with brain structures, in this case, the basal ganglia and its associated functional circuitry (e.g., see [39], for a discussion of structural and functional basal ganglia changes associated with aging).Such difficulties then cause problems in the tractability of models of age-related deficits, and even when specific behaviors are readily observable, there may be problems of generalizability when extrapolating to other domains.Models are possible, but there are problems of testability. This is because performance differences may simply reflect a strategic preference for accuracy over speed. As there is a tendency for differences in strategy to be inferred from performance decrements, this undermines any attributions of age-related changes in performance to structural changes. For there to be progress in the understanding of genuine age differences in performance, accounts of aging need to address strategic differences in performance while assessing structural deficits. This theoretical paper therefore seeks to address these problems by incorporating strategic variation into accounts of age-related changes in performance, delineating means whereby this can be addressed theoretically. By means of a discussion of empirical research, this paper demonstrates how strategic differences can be managed through the use of performance operating characteristics. Such solutions are therefore tractable and testable. Studies that control strategy reveal that the psychomot...

show abstract

Sensorimotor effects of pergolide, a dopamine agonist, in healthy subjects: a lateralized readiness potential study

Cited by 14 publications

References 73 publications

Influence of Stimulant Medication and Response Speed on Lateralization of Movement-Related Potentials in Attention-Deficit/Hyperactivity Disorder

Influence of Stimulant Medication and Response Speed on Lateralization of Movement-Related Potentials in Attention-Deficit/Hyperactivity Disorder

Impulsiveness as a timing disturbance: neurocognitive abnormalities in attention-deficit hyperactivity disorder during temporal processes and normalization with methylphenidate

Age-related slowing of movement as basal ganglia dysfunction

Contact Info

Product

Resources

About