Sensorimotor gating and vigilance-dependent choice accuracy: A within-subject correlative analysis in wild-type C57BL/6 mice

Bitanihirwe, Byron K.Y.; Dubroqua, Sylvain; Singer, Philipp; Feldon, Joram; Yee, Benjamin K.

doi:10.1016/j.bbr.2010.10.021

Cited by 13 publications

(14 citation statements)

References 74 publications

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“…The stimulus-onset asynchrony of the prepulse and pulse stimuli on all prepulse-plus-pulse trials was 100 ms (onset to onset). The PPI test procedure strictly followed protocols established and fully described previously (Bitanihirwe et al, 2011). For each of the three pulse intensities (100, 110, or 120 dB A ), PPI was indexed by percentage inhibition of the startle response obtained in the pulse-alone trials by the following expression: 100% ϫ [1 Ϫ (mean reactivity on prepulse-plus-pulse trials/ mean reactivity on pulse-alone trials)], for each subject, and at each of the three possible prepulse and pulse intensities.…”

Section: Prepulse Inhibition Of the Acoustic Startle Reflexmentioning

confidence: 99%

“…Sustained attention was assessed using an operant-based two-choice visual discrimination tests as established previously in mice (Bitanihirwe et al, 2011). Four operant chambers (model E10-10; Habitest System; Coulbourn Instruments) were used, each placed inside a ventilated and sound-attenuated box.…”

Section: Sustained Attention In a Two-choice Visual Discrimination Taskmentioning

confidence: 99%

“…Four operant chambers (model E10-10; Habitest System; Coulbourn Instruments) were used, each placed inside a ventilated and sound-attenuated box. The test chambers have been fully described previously (Bitanihirwe et al, 2011). The data were analyzed by the Graphic State (version 1.013) tracking system.…”

Section: Sustained Attention In a Two-choice Visual Discrimination Taskmentioning

confidence: 99%

“…Detailed information regarding the procedures used for the initial habituation and magazine training, lever press shaping, and acquisition of visual discrimination phases can be obtained elsewhere (Bitanihirwe et al, 2011). The animals were trained on the attentional task for an average of 9 d before the critical test was performed.…”

Section: Sustained Attention In a Two-choice Visual Discrimination Taskmentioning

confidence: 99%

“…Once the animals had achieved high accuracy (Ն80% on 2 consecutive days) in the acquisition of visual discrimination (for detailed information, see Bitanihirwe et al, 2011), the duration of the visual signal was reduced to 10, 2, 1, or 0.5 s. The animals were allowed a maximum of 30 s to perform a nose poke response following the presentation of the visual signal, before an omission would be recorded. Throughout the maximum number of 48 trials (i.e., 12 trials at each stimulus duration regardless of omission), every block of 4 trials randomly featured one of the four possible signal durations.…”

Section: Sustained Attention In a Two-choice Visual Discrimination Taskmentioning

confidence: 99%

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Prenatal Immune Activation Interacts with GeneticNurr1Deficiency in the Development of Attentional Impairments

Vuillermot

Joodmardi²,

Perlmann³

et al. 2012

J. Neurosci.

118

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Prenatal exposure to infection has been linked to increased risk of neurodevelopmental brain disorders, and recent evidence implicates altered dopaminergic development in this association. However, since the relative risk size of prenatal infection appears relatively small with respect to long-term neuropsychiatric outcomes, it is likely that this prenatal insult interacts with other factors in shaping the risk of postnatal brain dysfunctions. In the present study, we show that the neuropathological consequences of prenatal viral-like immune activation are exacerbated in offspring with genetic predisposition to dopaminergic abnormalities induced by mutations in Nurr1, a transcription factor highly essential for normal dopaminergic development. We combined a mouse model of heterozygous genetic deletion of Nurr1 with a model of prenatal immune challenge by the viral mimetic poly(I:C) (polyriboinosinic polyribocytidilic acid). In our gene-environment interaction model, we demonstrate that the combination of the genetic and environmental factors not only exerts additive effects on locomotor hyperactivity and sensorimotor gating deficits, but further produces synergistic effects in the development of impaired attentional shifting and sustained attention. We further demonstrate that the combination of the two factors is necessary to trigger maldevelopment of prefrontal cortical and ventral striatal dopamine systems. Our findings provide evidence for specific geneenvironment interactions in the emergence of enduring attentional impairments and neuronal abnormalities pertinent to dopamineassociated brain disorders such as schizophrenia and attention deficit/hyperactivity disorder, and further emphasize a critical role of abnormal dopaminergic development in these etiopathological processes.

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Section: Prepulse Inhibition Of the Acoustic Startle Reflexmentioning

confidence: 99%

Section: Sustained Attention In a Two-choice Visual Discrimination Taskmentioning

confidence: 99%

Section: Sustained Attention In a Two-choice Visual Discrimination Taskmentioning

confidence: 99%

Section: Sustained Attention In a Two-choice Visual Discrimination Taskmentioning

confidence: 99%

Section: Sustained Attention In a Two-choice Visual Discrimination Taskmentioning

confidence: 99%

See 3 more Smart Citations

Prenatal Immune Activation Interacts with GeneticNurr1Deficiency in the Development of Attentional Impairments

Vuillermot

Joodmardi²,

Perlmann³

et al. 2012

J. Neurosci.

118

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Baseline prepulse inhibition expression predicts the propensity of developing sensitization to the motor stimulant effects of amphetamine in C57BL/6 mice

et al. 2012

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Rationale The startle reflex to a sudden intense acoustic pulse stimulus is attenuated if the pulse is shortly preceded by a weak prepulse stimulus. This represents a form of sensory gating, known as prepulse inhibition (PPI), observable across species. PPI is modulated by dopamine and readily disrupted by acute amphetamine. Prior repeated exposures to amphetamine also disrupt PPI even when the drug is not present during test, suggesting that a sensitized mesolimbic dopamine system-inducible even by a single exposure to amphetamine-might be responsible. However, this causative link has been challenged by inconsistent efficacy between different amphetamine pre-treatment regimes, which all robustly sensitize the behavioral response to amphetamine. Methods Here, the presence of such a link in reverse was tested by comparing the propensity to develop amphetamine sensitization between high-and low-PPI expressing individuals identified within a homogeneous cohort of C57BL/6 mice. Comparison of dopamine content including its metabolites was performed separately in drug naïve mice by postmortem HPLC. Results Behavioral sensitization was substantially stronger in the low-PPI group compared with the high-PPI group, while the magnitude of their response to the first amphetamine challenge was similar. Dopamine content within the nucleus accumbens and medial prefrontal cortex was significantly higher in low-PPI relative to high-PPI mice. Conclusion Individuals with weak sensory gating characterized by low basal PPI expression may be more susceptible to the development of dopamine sensitization and therefore at greater risk of developing schizophrenia. Conversely, high baseline expression might predict a resistance to dopaminergic sensitization.

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Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task

et al. 2017

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Sensorimotor gating and vigilance-dependent choice accuracy: A within-subject correlative analysis in wild-type C57BL/6 mice

Cited by 13 publications

References 74 publications

Prenatal Immune Activation Interacts with GeneticNurr1Deficiency in the Development of Attentional Impairments

Prenatal Immune Activation Interacts with GeneticNurr1Deficiency in the Development of Attentional Impairments

Baseline prepulse inhibition expression predicts the propensity of developing sensitization to the motor stimulant effects of amphetamine in C57BL/6 mice

Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task

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