2001
DOI: 10.1016/s0006-3223(01)01184-2
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Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania

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Cited by 249 publications
(205 citation statements)
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“…Considering that reinforcement learning signals are conveyed to the cingulate cortex by the mesencephalic dopamine system (Holroyd and Coles, 2002), we suggest that dysfunctional NAcc activation during prediction error processing (as found in this study) leads to cortical and subcortical hyperactivity in mania (Caligiuri et al, 2003). Our findings add to the hypothesis that deficits in gating functions as measured by prepulse inhibition in manic patients may be due to impairments in the corticostriatial circuitry (Perry et al, 2001). Accordingly, unsuccessful motor inhibition was associated with decreased striatal fMRI activation in pediatric bipolar disorder.…”
Section: Outcomesupporting
confidence: 78%
“…Considering that reinforcement learning signals are conveyed to the cingulate cortex by the mesencephalic dopamine system (Holroyd and Coles, 2002), we suggest that dysfunctional NAcc activation during prediction error processing (as found in this study) leads to cortical and subcortical hyperactivity in mania (Caligiuri et al, 2003). Our findings add to the hypothesis that deficits in gating functions as measured by prepulse inhibition in manic patients may be due to impairments in the corticostriatial circuitry (Perry et al, 2001). Accordingly, unsuccessful motor inhibition was associated with decreased striatal fMRI activation in pediatric bipolar disorder.…”
Section: Outcomesupporting
confidence: 78%
“…Intriguingly, association of the 5-HT 2A receptor gene polymorphism with ADHD has been recently reported (Levitan et al, 2002). Furthermore, the behavioral phenotype of DAT KO mice also closely resembles that of bipolar depressive disorder in humans, as both exhibit general hyperactivity and deficits in PPI (Perry et al, 2001). The capacity of standard treatments for bipolar disorder, such as lithium, carbamazepine, and valproate, to reverse behavioral deficits in DAT KO mice remains to be determined in the further validation of these mice as a model of human disease.…”
Section: Discussionmentioning
confidence: 92%
“…This group of disorders has been suggested to reflect a family of disorders which can be characterized as having deficits in the gating of motor (Huntington's, Tourette's), sensory (schizophrenia), and/or cognitive information (OCD) Hoenig et al, 2005). In addition, more recent studies have revealed similar deficits in PPI in another psychotic disorder, namely bipolar disorder patients, at least in the manic phase of the illness (Perry et al, 2001). Bipolar disorder has long been conceptualized as including failure of motor inhibition.…”
Section: Sensorimotor Gating Deficits In Psychiatric Disordersmentioning
confidence: 99%