Sensorineural Hearing Loss in Otitis Media

Paparella, Michael M.; Morizono, Tetsuo; Le, Chap T.; Choo, Young Bin; Mancini, Fernando; Lidén, Gunnar; Sipilä, Pekka; Kim, Chong Sun

doi:10.1177/000348948409300616

Cited by 191 publications

(143 citation statements)

References 15 publications

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“…In the present investigation, average hearing loss of 40 Db was higher than the one observed in other series of cases, of which average varied from 19 to 33 Db in the frequencies of speech 6,15 . The longest duration of ear disease (12.4 years) up to the surgical intervention, with probable higher frequency of breakage in the ossicular chain could justify such difference 11 .…”

Section: Discussioncontrasting

confidence: 70%

“…Toxins produced by bacteria present in a chronic purulent secretion in the middle ear would cause more damage to the inner ear when compared to non-persistent otorrhea and the toxins production is not continuous 16,17 . Paparella et al showed, in an elegant experimental study this association between SNHL and SCOM 18 . They emphasized the deleterious consequences of chronic otorrhea for the inner ear.…”

Section: Discussionmentioning

confidence: 91%

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Perda auditiva sensório-neural na otite média crônica supurativa em pacientes com e sem colesteatoma

Azevedo

Pinto

Souza

et al. 2007

Rev. Bras. Otorrinolaringol.

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Sensori neural hearing loss (SNHL) related to chronic suppurative otitis media (CSOM) was studied to clarify the involvement of cholesteatomas in this context. Aim: to evaluate SNHL related to CSOM and its association with cholesteatomas, disease duration and patients' ages. Methods: Retrospective analysis of 115 patients with CSOM with and without cholesteatoma submitted to surgical treatment. Inclusion criteria were active unilateral disease, normal contralateral ear and age below 60 years. Results: The average age was 26.3 years, 58 males and 57 females. The duration of ear disease was, in average, 12.4 years. The average threshold of hearing was 40 dB in CSOM ear and 22 dB in the normal contralateral ear (P=0.002). CSOM with cholesteatoma occurred in 78 of 115 cases. In the abnormal ear, SNHL was seen in 15 cases, being 6 cases of profound loss, that correlated with adjusted-age (P=0.003) and absence of cholesteatoma (P=0.01), but not with disease duration (P=0.458). Conclusion: SNHL occurred in 13% of the patients with CSOM, and was correlated with older age, but not with the presence of cholesteatoma or longer duration of ear disease.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 91%

Perda auditiva sensório-neural na otite média crônica supurativa em pacientes com e sem colesteatoma

Azevedo

Pinto

Souza

et al. 2007

Rev. Bras. Otorrinolaringol.

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“…While direct involvement of cochlea [10] and enzymatic actions [11] have been considered as a cause for sensorineural hearing loss in otosclerosis and tympanosclerosis, chemical labyrinthitis (due to bacterial toxins and inflammatory intermediates) and infective labyrinthitis are considered the cause for depressed bone conduction in chronic otitis media with or without cholesteatoma [12]. Chronic otitis media can definitely cause labyrinthitis and can cause sensorineural hearing loss but it does not explain the reason behind the depressed bone conduction in so many patients without any symptoms of inner ear involvement.…”

Section: Discussionmentioning

confidence: 99%

Bone Conduction Improvement After Surgery for Conductive Hearing Loss

Vijayendra

Parikh

2011

Indian J Otolaryngol Head Neck Surg

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The objective is to evaluate change in postoperative bone conduction in patients who underwent surgery for conductive/mixed hearing loss due to various reasons. The study design is of retrospective case review and tertiary referral center setting. Five-hundred patients with unilateral conductive/mixed hearing loss were divided into five equal groups (each representing different causes for pre-operative hearing loss), who underwent appropriate surgical correction and had a follow-up audiogram available. The intervention comprises surgery (like myringoplasty and ossiculoplasty with closed or open cavity mastoidectomy for chronic otitis media, stapes mobilization for tympanosclerosis and stapedotomy for otosclerosis) for conductive/mixed hearing loss. Significant improvement or worsening in bone conduction was defined as 15 dB or more improvement or worsening of bone conduction threshold at least in two frequencies between 500 and 4000 Hz. All the other groups also showed a consistent preoperative bone conduction reduction with an equally consistent improvement in post-operative bone conduction improvement to a varying degree with otosclerosis group having maximum percentage of patients with post-operative bone conduction improvement (60%). The measurement of bone conduction is not necessarily a true reflection of the function of the inner ear. Middle ear makes a contribution to bone conduction and correction of a middle ear conductive lesion causes an apparent improvement in inner ear function. The apparent inner ear hearing loss caused in this way may be reversible to some extent.

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“…While the role of pH gating in the inner ear has not been well investigated, the study by Ikeda and Morizono (69) has suggested that CO 2 levels influence the acidbase regulation of inner ear fluids through the cochlear round window and that changes in CO 2 levels and pH can affect cochlear function. In severe cases, this might lead to sensorineural hearing loss that has been demonstrated in cases of patients with secretory otitis media (70).…”

Section: Connexon Extracellular Surface Is More Rigid When the Extracmentioning

confidence: 99%

Aminosulfonate Modulated pH-induced Conformational Changes in Connexin26 Hemichannels

Bippes

Hand

et al. 2007

Journal of Biological Chemistry

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Gap junction channels regulate cell-cell communication by passing metabolites, ions, and signaling molecules. Gap junction channel closure in cells by acidification is well documented; however, it is unknown whether acidification affects connexins or modulating proteins or compounds that in turn act on connexins. Protonated aminosulfonates directly inhibit connexin channel activity in an isoform-specific manner as shown in previously published studies. High-resolution atomic force microscopy of force-dissected connexin26 gap junctions revealed that in HEPES buffer, the pore was closed at pH < 6.5 and opened reversibly by increasing the pH to 7.6. This pH effect was not observed in non-aminosulfonate buffers. Increasing the protonated HEPES concentration did not close the pore, indicating that a saturation of the binding sites occurs at 10 mM HEPES. Analysis of the extracellular surface topographs reveals that the pore diameter increases gradually with pH. The outer connexon diameter remains unchanged, and there is a ϳ6.5°rotation in connexon lobes. These observations suggest that the underlying mechanism closing the pore is different from an observed Ca 2؉ -induced closure.Gap junction channels (GJC) 3 are dynamic macromolecular complexes capable of opening and closing the channel pore in response to a number of stimuli such as divalent cations, signaling molecules, phosphorylation, pH, and modulators of specific isoforms (1). These regulated conduits for the passage of small molecules greatly influence homeostasis, development, ionic transmission, and other cellular processes. Whereas there exist strong cell biological, biochemical, and biophysical evidence for the effects of these modulators, there is not much information at the structural level as to the conformational changes that occur in closing the pore in response to these stimuli.Each connexin (Cx) channel is composed of two hexamers (connexons) that dock at their apposed extracellular surfaces. The cyclic arrangement of the subunits within the hexamers suggests that gating can occur by a rotation and translation of the transmembrane segments within all six monomers. It has been postulated that gating occurs as a "camera iris" shutter (2). An alternate hypothesis has been proposed in which intra-connexin associations occur to produce either a particle-receptor blockage at the cytoplasmic surface (3, 4) or as a physical gate near the extracellular surface ("loop gate") (5). Whether these proposed mechanisms correlate to the closure of fast and/or slow gates that have been characterized by electrophysiological methods (see Ref. 6) remain to be determined.Gating by intracellular acidification is one way that connexin channels open and close in response to stimuli. Experimentally determined decreases in intracellular pH are known to decrease junctional electrical coupling in cardiomyocytes and in Purkinje fibers (7-10) as well as in teleost and amphibian embryos (11). Stergiopoulos et al. (12) showed that many, but not all, connexins close in a pH-sensit...

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Sensorineural Hearing Loss in Otitis Media

Cited by 191 publications

References 15 publications

Perda auditiva sensório-neural na otite média crônica supurativa em pacientes com e sem colesteatoma

Perda auditiva sensório-neural na otite média crônica supurativa em pacientes com e sem colesteatoma

Bone Conduction Improvement After Surgery for Conductive Hearing Loss

Aminosulfonate Modulated pH-induced Conformational Changes in Connexin26 Hemichannels

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