Sensorineural Hearing Loss in Unilateral Mucosal Type of Chronic Otitis Media

Soni, Sanjay; Malhotra, Vikas; Sharma, Raman; Passey, Jigyasa

doi:10.1007/s12070-023-03759-5

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Currently, there is growing interest in the research of COM‐associated SNHL. Sanjay et al found that the risk of SNHL increased with increasing patient age, disease duration, and size of the perforation, as well as smoking 8 . Jung et al found that cleaved cochlin LCCL (limulus factor C, cochlin, and Lgl1) may be a potential target for treating SNHL caused by CSOM 9 .…”

Section: Introductionmentioning

confidence: 99%

Gram‐negative Bacteria are Associated With Sensorineural Hearing Loss in Chronic Otitis Media

Lou,

He,

Cui

et al. 2024

The Laryngoscope

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ObjectChronic otitis media (COM) is an inflammatory disease that commonly presents with otorrhea and hearing loss. Bacteria‐induced inflammation can cause inner ear damage, leading to sensorineural hearing loss (SNHL). This study aimed to compare the prevalence and severity of SNHL in patients with gram‐negative versus gram‐positive cultures and examine associations between the concentrations of circulating monocytes and neutrophils with bacteria species and SNHL.MethodsThis was a retrospective study. Cholesteatoma or chronic suppurative otitis media patients with otorrhea were enrolled. Middle ear secretions were collected using sterile swabs under an otoscope, and sent for bacterial detection within 30 min. Pure tone audiometry and circulating leukocyte counts were recorded and analyzed in patients infected with different pathogens. Logistic regression analysis was used to identify the risk factors associated with SNHL.ResultsA total of 137 patients were enrolled, including 45 patients infected with gram‐negative bacteria, 41 with gram‐positive bacteria, 20 with polymicrobial infection, and 31 with no bacterial growth. Logistic regression analysis showed that bacterial culture positive infections (OR = 7.265, 95% CI 2.219–23.786, p = 0.001) were an independent risk factor for SNHL. Patients with gram‐negative bacteria had higher risks of SNHL (p < 0.0001) and more severe hearing loss (p = 0.005) than those with gram‐positive bacteria. COM patients infected with gram‐negative bacteria showed an increase in circulating monocytes, which correlated with the occurrence of SNHL (p = 0.0343).ConclusionGram‐negative bacteria are associated with elevated circulating monocyte counts and have a higher risk of severe SNHL.Level of Evidence4 Laryngoscope, 2024

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Section: Introductionmentioning

confidence: 99%