This article aims to properly assess the hygrothermal properties of walls located in historic buildings, this study discloses the development of a remote sensing technology compatible with an in-situ measurement implemented in Palazzo Tassoni (Italy). As required by the international recommendations adapted to cultural heritage (CH), this monitoring system balances CH conservation, performance aspects and economic costs using an integrated multidisciplinary approach. Electronics for measurement of environmental parameters is composed of sensor measurements, data acquisition system and data storage and communication system. Data acquisition system, equipped with standard modbus-rtu interface, is designed to run standalone and it is based on two cloned single board PCs to reduce the possibility of data loss. In order to reduce the costs, RaspberryPI single board PCs were chosen. These run a C/C++ software based on standard modbus library and designed to implement multi-client server TCP/IP to allow communication with other devices. Storage and communication systems are based on an industrial PC; it communicates with sensor measurements’ system through a modbus-TCPIP bridge. PC runs a Labview software to provide data storage on a local database and graphical user interface to properly see all acquired data. Herein, some sensing options and approaches of measurement are described, unveiling different possible ways of enhancing the retrofit of CH with adapted technology.