Sensors: Stretchable, Multiplexed pH Sensors With Demonstrations on Rabbit and Human Hearts Undergoing Ischemia (Adv. Healthcare Mater. 1/2014)

Chung, Hyun‐Joong; Sulkin, Matthew S.; Kim, Jong-Seon; Goudeseune, Camille; Chao, Hsin-Yun; Song, Joseph W.; Yang, Sang Yoon; Hsu, Yu‐I; Ghaffari, Roozbeh; Efimov, Igor R.; Rogers, John A.

doi:10.1002/adhm.201470002

Cited by 11 publications

(27 citation statements)

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“…Transducers convert variations of a physical signal into electrical information and vice versa. Sensing components to detect such signals are usually prepared in thin‐film format and include electrodes that record biopotentials, active transistors such as ion‐gated field‐effect transistors (IFET) or organic electrochemical transistors (OECT) that measure biosignals or the concentration of specific chemical species, physical sensors, e.g., strain gauges, temperature sensors, pH sensors, or integrated photodetectors . Conversely, the bioelectronic interface can deliver information to a selected biological system in the form of electrical pulses via stimulation electrodes or transistors, pulsed light distributed by light‐emitted diodes or optic fibers, chemical compounds to elicit localized pharmacological interactions, and ultrasound waves (yet to be demonstrated in implanted devices).…”

Section: Conformable Bioelectronic Systemsmentioning

confidence: 99%

“…Copyright 2015, AAAS. References in alphabetical order: Blaschke 2017, Canales 2015, Castagnola 2015, Chang 2013, Choi 2017, Chung 2014, Escabi 2014, Fang 2017, Feili 2008, Ferlauto 2018, Jeong 2015, Johnson 2018, Khodagholy 2013, Khodagholy 2015, Kim 2010a, Kim 2010b, Kim 2012, Kim 2013, Kim 2016, Kim 2019, Lee 2016, Lee 2017, Liu 2015, Liu 2019, Lu 2014, Lu 2017, Lu 2018, Luo 2016, Mathieson 2012, Mestais 2015, Mickle 2019, Minev 2015, Montgomery 2015, Muller 2015, Noh 2018, Park 2014, Park 2015, Park 2016a, Park 2016b, Park 2017, Piech 2018, Qi 2015, Reeder 2014, Rodriguez 2000, Rubehn 2009, Samineni 2017, Schuettler 2000, Sekitani 2016, Seo 2016, Shin 2017, Sivaji 2019, Song 2005, Tybrandt 2018, Viventi 2010, Viventi 2011, Volk 2015, Walter 2005, Williamson 2015, Xie 2015, Yokota 2015, Zhang 2019, Zhou 2017 …”

Section: Function and Compliance Of Bioelectronic Systemsmentioning

confidence: 99%

“…Copyright 2016, Cell Press. References in alphabetical order: Blaschke 2017, Chao 2010, Chung 2014, Escabi 2014, Fang 2017, Ganji 2018, Gkogkidis 2017, Khodagholy 2015, Khodagholy 2016, Kim 2010, Kim 2012, Lee 2016, Lee 2017, Liu 2015, Marcoleta 2018, Minev 2015, Muller 2015, Park 2014, Rubehn 2009, Seo 2016, Tybrandt 2018, Viventi 2010, Viventi 2011, Xie 2015 …”

Section: Function and Compliance Of Bioelectronic Systemsmentioning

confidence: 99%

“…Applications range from displays, photovoltaic panels, consumer electronics, and Internet developments in materials, micro fabrication processes, systems' integration, and biomedical engineering to deliver reliable, longterm, safe and precise communication inside the body. Target biological tissues are many, with prime applications within the central nervous system, [7,12] the peripheral nervous system, [13] the cardiovascular system, [14,15] but also other organs. [16][17][18] Conformability is a paramount property for these bioelectronic interfaces, ensuring both intimate contact for high efficacy and minimal invasiveness for biointegration.…”

Section: Introductionmentioning

confidence: 99%

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Conformable Hybrid Systems for Implantable Bioelectronic Interfaces

2019

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of Things (IoT) to wellness and medical technologies. In the past decade, significant efforts have been deployed to exploit these technologies to design and manufacture conformable bioelectronic interfaces.Mechanical compliance is a critical specification for the long-term integration of on-skin devices and implants with a biological host. The latter is largely composed of soft tissues, with Young's moduli E in the range from 100 Pa to 10 MPa (excluding bones and cartilage), [1] and sustains different physiological dynamic behaviors, e.g., repeated displacements of hundreds of micrometers at 1 Hz in the heart or brain, [2] volumetric changes up to 8% in the heart, [3] or large flexion and angular displacement in the skin or spinal cord. [4] In contrast, electronic materials are stiff, with the elastic modulus in the range of 1 GPa (organic materials) to 100 GPa (inorganic materials) and rigid, bearing little strain without displaying mechanical failure or defect generation. Interfaces between such disparate biological and man-made materials suffer therefore from a mechanical mismatch that hinders reliable and continued device function in the body. [1,5] Several approaches have been used to engineer mechanical compliance within an electronic device or circuit. [6] Outcomes of such conformable circuits include improved mitigation of foreign body reaction (FBR) in vivo compared to rigid interfaces, [7] access to so far unreachable regions, [8] and bidirectional communication with high spatiotemporal resolution with the biological host.Monolithic integration of electronic devices and circuits on semiconductor wafers offers extreme miniaturization and very high device density (e.g., >10 8 transistors mm −2 , Intel FinFET Technology nodes [9] ). Such large scale of integration cannot be achieved for electronics prepared on conformable carrier substrates, as this class of devices employs lower performance device materials and polymeric substrates with low chemical and/or thermal stability leading to limited lithographic resolution and large transistor sizes. These constraints typically worsen as the compliance of the substrate increases. Some of the highest device densities reported to date are >10 000 cm −2 on flexible substrate [10] and 347 cm −2 on stretchable carrier. [11] Conformable hybrid systems leverage the performance of standard complementary metal-oxide-semiconductor integrated circuits (ICs) and the compliance of discrete flexible or stretchable components and carriers, to effectively provide high-performance and mechanically compliant electronic circuits. They call for new Conformable bioelectronic systems are promising tools that may aid the understanding of diseases, alleviate pathological symptoms such as chronic pain, heart arrhythmia, and dysfunctions, and assist in reversing conditions such as deafness, blindness, and paralysis. Combining reduced invasiveness with advanced electronic functions, hybrid bioelectronic systems have evolved tremendously in the last decade, pushed by progress in materials ...

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Section: Conformable Bioelectronic Systemsmentioning

confidence: 99%

Section: Function and Compliance Of Bioelectronic Systemsmentioning

confidence: 99%

Section: Function and Compliance Of Bioelectronic Systemsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Conformable Hybrid Systems for Implantable Bioelectronic Interfaces

2019

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“…Stretchable electronics ( Kim et al., 2011; Chung et al., 2014 ) constitute a new technology that may allow integration of voltage sensors on conventional balloon catheter membranes, opening up the possibility of high-density measurements with minimally invasive procedures. In a similar way, elastic integumentary membranes, produced via 3D printing to match the shape of the heart, may provide an improved picture of both EP and mechanical response ( Xu et al., 2014 ).…”

Section: From Anatomy To Functionmentioning

confidence: 99%

Images as drivers of progress in cardiac computational modelling

Lamata

Casero

Carapella

et al. 2014

Progress in Biophysics and Molecular Biology

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Computational models have become a fundamental tool in cardiac research. Models are evolving to cover multiple scales and physical mechanisms. They are moving towards mechanistic descriptions of personalised structure and function, including effects of natural variability. These developments are underpinned to a large extent by advances in imaging technologies. This article reviews how novel imaging technologies, or the innovative use and extension of established ones, integrate with computational models and drive novel insights into cardiac biophysics. In terms of structural characterization, we discuss how imaging is allowing a wide range of scales to be considered, from cellular levels to whole organs. We analyse how the evolution from structural to functional imaging is opening new avenues for computational models, and in this respect we review methods for measurement of electrical activity, mechanics and flow. Finally, we consider ways in which combined imaging and modelling research is likely to continue advancing cardiac research, and identify some of the main challenges that remain to be solved.

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Lattice Proton Intercalation to Regulate WO₃‐Based Solid‐Contact Wearable pH Sensor for Sweat Analysis

Tang

Gan

Zhong

et al. 2021

Adv Funct Materials

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Sweat pH monitoring is a routine indicator in wearable biotechnology. The state-of-the-art wearable pH sensors mostly rely on organic materials but face the risk of biological toxicity. WO 3 is a typical H + -sensitive inorganic material with chemical stability, biocompatibility, and low cost but low sensitivity and slow response. Lattice H + intercalation is herein proposed as an efficient approach that can greatly improve the sensitivity and selectivity of WO 3based pH sensors. Specifically, lattice H + intercalation can promote WO 3 from the monoclinic phase to cubic phase, which enhances the ion exchange capacity between WO 3 and H + . The resistance decreases more than two orders of magnitudes, which improves the interfacial charge transport. The occupancy of lattice H + leads to ion exchange only with H + , thus increasing the H + recognition. The intercalated H x WO 3 exhibits much improved sensitivity, reversibility, and response time. Additionally, the H x WO 3 is integrated with a solid reference electrode on a miniaturized chip for wearable sweat pH monitoring. The pH sensor exhibits good potential response even at curving over 270°. On-body sweat pH measurments show high accuracy compared with ex situ analyses. This work emphasizes the concept of lattice proton intercalation to regulate the H + recognition of solid contacts.

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Sensors: Stretchable, Multiplexed pH Sensors With Demonstrations on Rabbit and Human Hearts Undergoing Ischemia (Adv. Healthcare Mater. 1/2014)

Cited by 11 publications

References 1 publication

Conformable Hybrid Systems for Implantable Bioelectronic Interfaces

Conformable Hybrid Systems for Implantable Bioelectronic Interfaces

Images as drivers of progress in cardiac computational modelling

Lattice Proton Intercalation to Regulate WO₃‐Based Solid‐Contact Wearable pH Sensor for Sweat Analysis

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Sensors: Stretchable, Multiplexed pH Sensors With Demonstrations on Rabbit and Human Hearts Undergoing Ischemia (Adv. Healthcare Mater. 1/2014)

Cited by 11 publications

References 1 publication

Conformable Hybrid Systems for Implantable Bioelectronic Interfaces

Conformable Hybrid Systems for Implantable Bioelectronic Interfaces

Images as drivers of progress in cardiac computational modelling

Lattice Proton Intercalation to Regulate WO3‐Based Solid‐Contact Wearable pH Sensor for Sweat Analysis

Contact Info

Product

Resources

About

Lattice Proton Intercalation to Regulate WO₃‐Based Solid‐Contact Wearable pH Sensor for Sweat Analysis