Sensory and pulmonary effects of acute exposure to sulfur dioxide (SO2)

Thriel, Christoph van; Schäper, Michael; Kleinbeck, Stefan; Kiesswetter, Ernst; Blaszkewicz, Meinolf; Golka, Klaus; Nies, Eberhard; Raulf‐Heimsoth, Monika; Brüning, Thomas

doi:10.1016/j.toxlet.2010.03.013

Cited by 52 publications

(20 citation statements)

References 49 publications

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“…The only other studies are: one showing no pulmonary response in healthy adults below 2 ppm (van Thriel et al, 2010); and one showing a reduction in cardiac vagal control (root mean square of the successive differences (RMSSD)) in 20 normal subjects, but not those with stable angina, 4 hours (but not 1 hour) after exposure to 572 μg/m 3 (0.2 ppm) SO 2 for 1 hour (Routledge et al, 2006). Baroreflex sensitivity was also reduced.…”

Section: Chamber Study Evidencementioning

confidence: 99%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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This document presents answers to 24 questions relevant to reviewing European policies on air pollution and to addressing health aspects of these policies. The answers were developed by a large group of scientists engaged in the WHO project "Review of evidence on health aspects of air pollution -REVIHAAP". The experts reviewed and discussed the newly accumulated scientific evidence on the adverse effects on health of air pollution, formulating science-based answers to the 24 questions. Extensive rationales for the answers, including the list of key references, are provided. The review concludes that a considerable amount of new scientific information on the adverse effects on health of particulate matter, ozone and nitrogen dioxide, observed at levels commonly present in Europe, has been published in recent years. This new evidence supports the scientific conclusions of the WHO air quality guidelines, last updated in 2005, and indicates that the effects in some cases occur at air pollution concentrations lower than those serving to establish these guidelines. It also provides scientific arguments for taking decisive actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.This publication arises from the project REVIHAAP and has been co-funded by the European Union. Keywords AIR POLLUTANTS AIR POLLUTION -ADVERSE EFFECTS ENVIRONMENT AND PUBLIC HEALTH EVIDENCE BASED PRACTICE GUIDELINES HEALTH POLICYAddress requests about publications of the WHO Regional Office for Europe to: Publications WHO Regional Office for Europe Scherfigsvej 8 DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote or translate, on the Regional Office web site (http://www.euro.who.int/pubrequest). © World Health Organization 2013All rights reserved. The Regional Office for Europe of the World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate borderlines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. ...

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Section: Chamber Study Evidencementioning

confidence: 99%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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“…No relevant difference was observed between male and female mice in the sensory irritation response to sulphur dioxide (Alarie et al 1980), which is also observed in humans (van Thriel et al 2010) suggesting a similar receptor sensitivity in the two gender. Inbred mice were purchased from Taconic, Denmark.…”

Section: Methodsmentioning

confidence: 93%

Acute airway irritation of methyl formate in mice

Larsen

Nielsen

2011

Arch Toxicol

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Methyl formate (MF) is a volatile solvent with several industrial applications. The acute airway effects of MF were evaluated in a mouse bioassay, allowing the assessment of sensory irritation of the upper airways, airflow limitation of the conducting airways and deep lung (pulmonary) irritation. MF was studied at vapour concentrations of 202–1,168 ppm. Sensory irritation was the only effect observed, which developed slowly over the 30-min exposure period. The potency at steady state was at least 10-fold higher than expected from a hypothetically similar, but non-reactive compound. Methyl formate may be hydrolysed in vivo to formic acid, a potent sensory irritant, and methanol, a low-potent sensory irritant. Hydrolysis may be catalysed by carboxyesterases, and therefore, the role of the esterases was studied using the esterase inhibitor tri-ortho-cresyl phosphate (TOCP). TOCP pre-treatment reduced the irritation response of MF, suggesting that carboxyesterase-mediated hydrolysis plays a role in the irritative effect. However, even after administration of TOCP, MF was considerably more irritating than expected from a quantitative structure–activity relationship (QSAR) model. The slope of the concentration–effect relationship for formic acid was lower than that for the MF in the low-dose range, suggesting that different receptor activation mechanisms may occur, which may include an effect of MF itself, in addition to an effect of formic acid and potentially an effect from formaldehyde.

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“…Chemosensory effects of ethyl acrylate were assessed by a visual analog scale (VAS) using the format of the 'labeled magnitude scale' (LMS; Green et al 1996) that mimics the ratio-like properties of magnitude estimation scaling (Green et al 1996). LMS is a widely used scale to rate the intensity of chemosensory stimuli (Hey et al 2009;Juran et al 2012;Kleinbeck et al 2008Kleinbeck et al , 2017van Thriel et al 2005van Thriel et al , 2007avan Thriel et al , 2010.…”

Section: Ratings Of Intensity Of Chemosensory Sensationsmentioning

confidence: 99%

A short-term inhalation study to assess the reversibility of sensory irritation in human volunteers

et al. 2020

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Sensory irritation is an acute adverse effect caused by chemicals that stimulate chemoreceptors of the upper respiratory tract or the mucous membranes of the outer eye. The avoidance of this end point is of uttermost importance in regulatory toxicology. In this study, repeated exposures to ethyl acrylate were analyzed to investigate possible carryover effects from day to day for different markers of sensory irritation. Thirty healthy subjects were exposed for 4 h on five subsequent days to ethyl acrylate at concentrations permitted by the German occupational exposure limit at the time of study. Ratings of eye irritation as well as eye blinking frequencies indicate the elicitation of sensory irritation. These markers of sensory irritation showed a distinct time course on every single day. However, cumulative carryover effects could not be identified across the week for any marker. The rhinological and biochemical markers could not reveal hints for more pronounced sensory irritation. Neither increased markers of neurogenic inflammation nor markers of immune response could be identified. Furthermore, the performance on neurobehavioral tests was not affected by ethyl acrylate and despite the strong odor of ethyl acrylate the participants improved their performances from day to day. While the affected physiological marker, the increased eye blinking frequency stays roughly on the same level across the week, subjective markers like perception of eye irritation decrease slightly from day to day though the temporal pattern of, i.e., eye irritation perception stays the same on each day. A hypothetical model of eye irritation time course derived from PK/PD modeling of the rabbit eye could explain the withinday time course of eye irritation ratings repeatedly found in this study more precisely.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Sensory and pulmonary effects of acute exposure to sulfur dioxide (SO2)

Cited by 52 publications

References 49 publications

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Acute airway irritation of methyl formate in mice

A short-term inhalation study to assess the reversibility of sensory irritation in human volunteers

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