Sensory and social subtypes of Japanese individuals with autism spectrum disorders

Kaneko, Ayako; Ohshima, Remi; Noda, Haruka; Matsumaru, Tomoko; Iwanaga, Ryoichiro; Ide, Masakazu

doi:10.31234/osf.io/umvcn

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…To support this possibility, several lines of evidence suggest functional alterations within and between subcortical and somatomotor networks (11, 45, 46) and their associations with the clinical symptoms, such as restricted and repetitive behaviors and atypical sensory processing (21, 41) . Furthermore, the association between atypical sensory processing and socio-communicative impairments is supported by previous literature (51, 52) . Replicability, associations with core symptoms, and consistency of abnormalities through developmental stages may distinguish these networks as a core basis for ASD.…”

Section: Discussionsupporting

confidence: 83%

Generalizable neuromarker for autism spectrum disorder across imaging sites and developmental stages: A multi-site study

Itahashi

Yamashita

Takahara

et al. 2023

Preprint

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Autism spectrum disorder (ASD) is a lifelong condition, and its underlying biological mechanisms remain elusive. The complexity of various factors, including inter-site and development-related differences, makes it challenging to develop generalizable neuroimaging-based biomarkers for ASD. This study used a large-scale, multi-site dataset of 730 Japanese adults to develop a generalizable neuromarker for ASD across independent sites (U.S., Belgium, and Japan) and different developmental stages (children and adolescents). Our adult ASD neuromarker achieved successful generalization for the US and Belgium adults (area under the curve [AUC] = 0.70) and Japanese adults (AUC = 0.81). The neuromarker demonstrated significant generalization for children (AUC = 0.66) and adolescents (AUC = 0.71; all P<0.05, family-wise-error corrected). We identified 141 functional connections (FCs) important for discriminating individuals with ASD from TDCs. These FCs largely centered on social brain regions such as the amygdala, hippocampus, dorsomedial and ventromedial prefrontal cortices, and temporal cortices. Finally, we mapped schizophrenia (SCZ) and major depressive disorder (MDD) onto the biological axis defined by the neuromarker and explored the biological continuity of ASD with SCZ and MDD. We observed that SCZ, but not MDD, was located proximate to ASD on the biological dimension defined by the ASD neuromarker. The successful generalization in multifarious datasets and the observed relations of ASD with SCZ on the biological dimensions provide new insights for a deeper understanding of ASD.

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Section: Discussionsupporting

confidence: 83%

Generalizable neuromarker for autism spectrum disorder across imaging sites and developmental stages: A multi-site study

Itahashi

Yamashita

Takahara

et al. 2023

Preprint

View full text Add to dashboard Cite

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Child Developmental MRI (CDM) project: protocol for a multi-centre, cross-sectional study on elucidating the pathophysiology of attention-deficit/hyperactivity disorder and autism spectrum disorder through a multi-dimensional approach

et al. 2023

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IntroductionNeuroimaging studies on attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) have demonstrated differences in extensive brain structure, activity and network. However, there remains heterogeneity and inconsistency across these findings, presumably because of the diversity of the disorders themselves, small sample sizes, and site and parameter differences in MRI scanners, and their overall pathogenesis remains unclear. To address these gaps in the literature, we will apply the travelling-subject approach to correct site differences in MRI scanners and clarify brain structure and network characteristics of children with ADHD and ASD using large samples collected in a multi-centre collaboration. In addition, we will investigate the relationship between these characteristics and genetic, epigenetic, biochemical markers, and behavioural and psychological measures.Methods and analysisWe will collect resting-state functional MRI (fMRI) and T1-weighted and diffusion-weighted MRI data from 15 healthy adults as travelling subjects and 300 children (ADHD, n=100; ASD, n=100; and typical development, n=100) with multi-dimensional assessments. We will also apply data from more than 1000 samples acquired in our previous neuroimaging studies on ADHD and ASD.Ethics and disseminationThe study protocol has been approved by the Research Ethics Committee of the University of Fukui Hospital (approval no: 20220601). Our study findings will be submitted to scientific peer-reviewed journals and conferences.

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Sensory and social subtypes of Japanese individuals with autism spectrum disorders

Cited by 2 publications

References 17 publications

Generalizable neuromarker for autism spectrum disorder across imaging sites and developmental stages: A multi-site study

Generalizable neuromarker for autism spectrum disorder across imaging sites and developmental stages: A multi-site study

Child Developmental MRI (CDM) project: protocol for a multi-centre, cross-sectional study on elucidating the pathophysiology of attention-deficit/hyperactivity disorder and autism spectrum disorder through a multi-dimensional approach

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