Sensory discrimination capabilities in patients with focal hand dystonia

Bara‐Jimenez, William; Shelton, Patricia; Sanger, Terence D.; Hallett, Mark

doi:10.1002/1531-8249(200003)47:3<377::aid-ana16>3.3.co;2-u

Cited by 40 publications

(61 citation statements)

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“…This view suggests that synchronous activation of several digits by vigorous and frequent musical practice leads to a disordered and smeared representation of the fingers in somatosensory and probably also in motor cortex, with the inability to move the most affected fingers separately (2,18). Also, sufficient evidence now exists to demonstrate a corresponding defective perception and abnormal sensory processing in focal hand dystonia (5,(19)(20)(21)(22). Given these abnormalities as well as the difficulties in currently available symptomatic treatments, new sensory and motor training programs have been developed and tested (3,4,23).…”

mentioning

confidence: 95%

Effective behavioral treatment of focal hand dystonia in musicians alters somatosensory cortical organization

Candia

Wienbruch

Elbert

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

158

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New perspectives in neurorehabilitation suggest that behavioral treatments of movement disorders may modify the functional organization of central somatosensory neural networks. On the basis of the assumption that use-dependent reorganization in these networks contributes to the fundamental abnormalities seen in focal dystonia, we treated 10 affected musicians and measured the concomitant somatosensory changes by using whole-head magnetoencephalography. We found that effective treatment, using the method of sensory motor retuning, leads to alterations in the functional organization of the somatosensory cortex. Specifically, before treatment, somatosensory relationships of the individual fingers differ between the affected and unaffected hands, whereas after treatment, finger representations contralateral to the dystonic side become more similar to the less-affected side. Further, somatosensory finger representations are ordered more according to homuncular principles after treatment. In addition, the observed physiologic changes correlated with behavioral data. These results confirm that plastic changes in parallel with emergent neurological dysfunction may be reversed by contextspecific, intensive training-based remediation.

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mentioning

confidence: 95%

Effective behavioral treatment of focal hand dystonia in musicians alters somatosensory cortical organization

Candia

Wienbruch

Elbert

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

158

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“…Se ha reportado síndrome biopercular con distonías focales (posturas distónicas en manos), relacionadas con lesiones del lóbulo parietal contralateral, que se cree que ocurren por alteración de la sensibilidad profunda discriminadora (12,13).…”

Section: Discussionunclassified

Síndrome biopercular: presentación de dos casos y revisión de la literatura

et al. 2008

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El síndrome biopercular es una parálisis pseudobulbar cortical causada por lesiones bilaterales que comprometen el opérculo cerebral anterior. Se caracteriza por preservación de la función refleja y de la actividad automática, sin deterioro mental. Se presentan dos casos clínicos y se hace una revisión de la literatura. Caso 1. Se trata de una mujer de 73 años de edad con antecedentes de enfermedad cerebrovascular hace siete años sin secuelas. Presentó pérdida súbita del conocimiento y en el examen neurológico se le encontró paresia facial central derecha y anartria, con actos reflejos como sonreír, parpadear y bostezar -los cuales no se producían al mandato-, hemiparesia derecha e imposibilidad para la marcha. En la tomografía cerebral se encontraron signos de lesión isquémica antigua en el territorio de la arteria cerebral media derecha. Por el compromiso motor derecho, que no se correlacionaba con los hallazgos de la imagen inicial, se solicitó nueva tomografía, en la que se evidenció infarto agudo en territorio de la arteria cerebral media izquierda. Caso 2. Se trata de una niña de ocho años con retardo mental y trastorno en el desarrollo del lenguaje verbal por paquigiria biopercular. Las pacientes presentan diplejía facio-faringo-gloso-masticatoria y parálisis volitiva selectiva de músculos oro-faciales. La evaluación neuropsicológica evidenció compromiso cognitivo, emocional y de la interacción social como parte de un síndrome de la convexidad frontal en el primer caso y, de retardo mental, en el segundo caso. La fonoaudiología demostró que las dos pacientes tenían dificultades en el proceso de masticación y deglución, y dificultades graves en el lenguaje verbal. El pronóstico de recuperación del lenguaje verbal es pobre, pero muchos pacientes pueden recuperar la deglución.Palabras clave: infarto cerebral, parálisis seudobulbar, retraso mental, trastornos de la deglución, trastornos del lenguaje. Biopercular syndrome: report of two cases and literature reviewThe anterior opercular or biopercular syndrome is a cortical pseudobulbar palsy due to bilateral lesions of the anterior brain operculum. It is characterized by preservation of reflex function and automatic activity, without mental impairment. Two cases are reported herein and the relevant literature reviewed. The first case was a 73-year-old female with a history of a stroke occurring seven years previously, without sequelae in the interim. She presented with sudden loss of consciousness. The neurological examination showed a right facial central palsy and anarthria, with reflex acts such as smiling, blinking and yawning, not elicited by commands; she also had a right hemiparesis and walking impairment. A brain CT scan showed an old ischemic infarction in the region of the right medial cerebral artery. Because the right motor involvement did not correlate with the findings of the initial CT scan, another CT scan two days later showed an acute brain infarction in the vicinity of the left medial cerebral artery. The second case was an 8-year-old girl w...

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“…However, when cTBS was applied over SI, subjects showed significant difficulties in tasks involving dexterity, tracking and aiming, suggesting a vital role for SI in motor behavior [46]. Temporal discrimination thresholds occur in 40 -69 ms in healthy controls and require 100 -155 ms in FHD [47][48][49]. Similarly, spatial processing of tactile information is abnormal such that gap detection and point localization thresholds are higher [47] and patients show compromised ability to determine the orientation of ne spatial gratings [48].…”

Section: In Uence Of Somatosensory Cortex On Motor Behaviormentioning

confidence: 99%

“…Temporal discrimination thresholds occur in 40 -69 ms in healthy controls and require 100 -155 ms in FHD [47][48][49]. Similarly, spatial processing of tactile information is abnormal such that gap detection and point localization thresholds are higher [47] and patients show compromised ability to determine the orientation of ne spatial gratings [48]. Aberrations in somatotopy also exist in FHD indicating reduced inter-digit spacing and abnormalities in the topographic ordering [50][51][52].…”

Section: In Uence Of Somatosensory Cortex On Motor Behaviormentioning

confidence: 99%

Promoting plasticity in the somatosensory cortex to alter motor physiology

Jones

Nelson

2014

Translational Neuroscience

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horn [15].The functional signi cance of the somatosensory-motor cortical interaction has been studied at great lengths in animal models and has led to di erent interpretations about the role of somatic cortex in motor control.Tetanic stimulation of cat somatosensory cortex leads to long-term potentiation (LTP) in M1 and is interpreted as a pathway important for motor skill learning [16,17]. Similarly, lesions in monkey somatosensory cortex impairs the acquisition of new motor skills but does not affect the performance of existing motor skills [18]. In monkeys at rest, cooling PROMOTING PLASTICITY IN THE SOMATOSENSORY CORTEX TO ALTER MOTOR PHYSIOLOGY AbstractSomatosensory pathways and cortices contribute to the control of human movement. In humans, non-invasive transcranial magnetic stimulation techniques to promote plasticity within somatosensory pathways and cortices have revealed potent effects on the neurophysiology within motor cortices. In this mini-review, we present evidence to indicate that somatosensory cortex is positioned to influence motor cortical circuits and as such, is an ideal target for plasticity approaches that aim to alter motor physiology and behavior in clinical populations.

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Sensory discrimination capabilities in patients with focal hand dystonia

Cited by 40 publications

References 0 publications

Effective behavioral treatment of focal hand dystonia in musicians alters somatosensory cortical organization

Effective behavioral treatment of focal hand dystonia in musicians alters somatosensory cortical organization

Síndrome biopercular: presentación de dos casos y revisión de la literatura

Promoting plasticity in the somatosensory cortex to alter motor physiology

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