Sensory-driven and spontaneous gamma oscillations engage distinct cortical circuitry

Welle, Cristin G.; Contreras, Diego

doi:10.1152/jn.00137.2015

Cited by 41 publications

(41 citation statements)

References 81 publications

(88 reference statements)

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“…Unlike broadband gamma rhythms, which involve inhibitory currents (Cardin et al., 2009, Hasenstaub et al., 2005, Sohal et al., 2009, Welle and Contreras, 2016), the narrowband gamma oscillation was primarily mediated by excitatory synaptic currents (EPSCs) (Figure 1E). To uncover the synaptic basis of the narrowband oscillation, we analyzed intracellular recordings from layer 2/3 regular-spiking (putative pyramidal) neurons in V1 of awake mice viewing a uniform gray screen (Haider et al., 2013) (Figure 1E).…”

Section: Resultsmentioning

confidence: 99%

“…The gamma rhythms between 30 and 90 Hz have long been described in multiple species including cats (Eckhorn et al., 1988, Gray and Singer, 1989), primates (Fries et al., 2001, Kreiter and Singer, 1992, Pesaran et al., 2002), humans (Tallon et al., 1995), and mice (Cardin et al., 2009, Sohal et al., 2009, Welle and Contreras, 2016). We refer to these rhythms between 30 and 90 Hz as broadband gamma.…”

Section: Introductionmentioning

confidence: 99%

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Subcortical Source and Modulation of the Narrowband Gamma Oscillation in Mouse Visual Cortex

Saleem

Lien

Krumin

et al. 2017

Neuron

155

167

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SummaryPrimary visual cortex exhibits two types of gamma rhythm: broadband activity in the 30–90 Hz range and a narrowband oscillation seen in mice at frequencies close to 60 Hz. We investigated the sources of the narrowband gamma oscillation, the factors modulating its strength, and its relationship to broadband gamma activity. Narrowband and broadband gamma power were uncorrelated. Increasing visual contrast had opposite effects on the two rhythms: it increased broadband activity, but suppressed the narrowband oscillation. The narrowband oscillation was strongest in layer 4 and was mediated primarily by excitatory currents entrained by the synchronous, rhythmic firing of neurons in the lateral geniculate nucleus (LGN). The power and peak frequency of the narrowband gamma oscillation increased with light intensity. Silencing the cortex optogenetically did not abolish the narrowband oscillation in either LGN firing or cortical excitatory currents, suggesting that this oscillation reflects unidirectional flow of signals from thalamus to cortex.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Subcortical Source and Modulation of the Narrowband Gamma Oscillation in Mouse Visual Cortex

Saleem

Lien

Krumin

et al. 2017

Neuron

155

167

View full text Add to dashboard Cite

show abstract

“…Consistent with prior reports (Nase et al . ; Niell & Stryker, ; Welle & Contreras, ), high contrast visual gratings generated strong oscillatory activity, recorded extracellularly via the local field potential (LFP), and a mixture of excitation and inhibition, recorded intracellularly with whole cell patch clamp from neurons in L2/3 (Fig. A – F ).…”

Section: Resultsmentioning

confidence: 99%

“…; Whittington et al . ; Welle & Contreras, ), but it remains unclear which subpopulations of cortical neurons are sufficient to drive oscillatory activity.…”

Section: Introductionmentioning

confidence: 99%

Layer‐specific excitation/inhibition balances during neuronal synchronization in the visual cortex

Adesnik

2018

The Journal of Physiology

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Rhythmic activity can synchronize neural ensembles within and across cortical layers. While gamma band rhythmicity has been observed in all layers, the laminar sources and functional impacts of neuronal synchronization in the cortex remain incompletely understood. Here, layer-specific optogenetic stimulation demonstrates that populations of excitatory neurons in any cortical layer of the mouse's primary visual cortex are sufficient to powerfully entrain neuronal oscillations in the gamma band. Within each layer, inhibition balances excitation and keeps activity in check. Across layers, translaminar output overcomes inhibition and drives downstream firing. These data establish that rhythm-generating circuits exist in all principle layers of the cortex, but provide layer-specific balances of excitation and inhibition that may dynamically shape the flow of information through cortical circuits. These data might help explain how excitation/inhibition (E/I) balances across cortical layers shape information processing, and shed light on the diverse nature and functional impacts of cortical gamma rhythms.

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“…In addition, because electric fields propagate in the brain, LFP recordings may also reflect propagated signals from nearby sources, a process that is known as volume conduction, which is particularly relevant when strong generators for the observed oscillatory phenomena are known to exist. Convergent evidence suggests that higher frequency oscillations in the beta and gamma range tend to reflect local synchronized firing and are not passively propagated over large distances (Steriade and Amzica, 1996;Buzsáki and Wang, 2012;Welle and Contreras, 2016). Low frequency LFP modulations in delta, theta and alpha bands however need to be interpreted with particular caution, given the robust, large amplitude, and highly synchronized theta oscillations that are present in the hippocampus that have been shown to affect cortical LFP recordings particularly in the rat where these structures are in close proximity (Buzsáki, 2002;Sirota et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Gamma band directional interactions between basal forebrain and visual cortex during wake and sleep states

Nair

Klaassen

Poirot

et al. 2016

Journal of Physiology-Paris

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The basal forebrain (BF) is an important regulator of cortical excitability and responsivity to sensory stimuli, and plays a major role in wake-sleep regulation. While the impact of BF on cortical EEG or LFP signals has been extensively documented, surprisingly little is known about LFP activity within BF. Based on bilateral recordings from rats in their home cage, we describe endogenous LFP oscillations in the BF during quiet wakefulness, rapid eye movement (REM) and slow wave sleep (SWS) states. Using coherence and Granger causality methods, we characterize directional influences between BF and visual cortex (VC) during each of these states. We observed pronounced BF gamma activity particularly during wakefulness, as well as to a lesser extent during SWS and REM. During wakefulness, this BF gamma activity exerted a directional influence on VC that was associated with cortical excitation. During SWS but not REM, there was also a robust directional gamma band influence of BF on VC. In all three states, directional influence in the gamma band was only present in BF to VC direction and tended to be regulated specifically within each brain hemisphere. Locality of gamma band LFPs to the BF was confirmed by demonstration of phase locking of local spiking activity to the gamma cycle. We report novel aspects of endogenous BF LFP oscillations and their relationship to cortical LFP signals during sleep and wakefulness. We link our findings to known aspects of GABAergic BF networks that likely underlie gamma band LFP activations, and show that the Granger causality analyses can faithfully recapitulate many known attributes of these networks.

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Sensory-driven and spontaneous gamma oscillations engage distinct cortical circuitry

Abstract: Welle CG, Contreras D. Sensory-driven and spontaneous gamma oscillations engage distinct cortical circuitry.

Cited by 41 publications

References 81 publications

Subcortical Source and Modulation of the Narrowband Gamma Oscillation in Mouse Visual Cortex

Subcortical Source and Modulation of the Narrowband Gamma Oscillation in Mouse Visual Cortex

Layer‐specific excitation/inhibition balances during neuronal synchronization in the visual cortex

Gamma band directional interactions between basal forebrain and visual cortex during wake and sleep states

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