Sensory function in headache: a comparative study among patients with cluster headache, migraine, tension-type headache, and asymptomatic subjects

Malo-Urriés, Miguel; Estébanez-de-Miguel, Elena; Bueno-Gracía, Elena; Tricás-Moreno, José Miguel; Santos-Lasaosa, S; Hidalgo-García, César

doi:10.1007/s10072-020-04384-8

Cited by 13 publications

(22 citation statements)

References 37 publications

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“…After removing duplicates, 611 studies remained. Five hundred and eighty-seven (n = 587) were excluded based on examination of their title and/or abstract, leaving 24 articles (27–50), for full-text analysis. Three studies were excluded because they did not include a control group (40–42) and one because it had an experimental design (43).…”

Section: Resultsmentioning

confidence: 99%

“…Three studies were excluded because they did not include a control group (40–42) and one because it had an experimental design (43). Finally, 20 studies (27–39,44–50), were included in the systematic review and meta-analysis (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…The methodological quality scores ranged from 4 to 8 (mean: 6.1, SD: 1.1) out of a maximum of 9. Three studies were considered of poor quality (4 stars) (27,36,39), nine were of fair methodological quality (5–6 stars) (29,32,35,37,44,45,47,48,50), and eight were of good quality (7 stars) (30,31,33,34,38,46,49,51). The most frequent biases were lack of control for additional factors as psychological aspects (e.g.…”

Section: Resultsmentioning

confidence: 99%

“…The meta-analysis found that patients with TTH exhibited significant reduced PPT at the head (MD −49.11, 95% CI −66.05 to −32.17, n = 2347, Z = 5.68, p < 0.001, Figure 3), the neck (MD −88.17, 95% CI −108.43 to −67.92, Z = 8.53, p < 0.001, Figure 4) and distant pain-free (MD: −98.43, 95% CI −136.78 to −60.09, Z = 5.03, p < 0.001, Figure 5) areas with high heterogeneity (I 2 > 75%) between studies in all the meta-analyses. The heterogeneity was related to the same study (38) on TTH classification in all analyses, and to just one in CTTH (head (27), neck (30), and distant pain-free (44) analyses) and FEETH (head (39), neck (37), and distant pain-free (47) analyses) classifications. The funnel plot showed asymmetry in overall PPTs at the trigeminal area (Supplemental Figure 1) with a significant Egger’s test ( p = 0.0028); therefore, high risk of publication bias was possible, but mostly due to just one study (38).…”

Section: Resultsmentioning

confidence: 99%

“…The heterogeneity was related to the same study (38) on TTH classification in all analyses, and to just one in CTTH (head (27), neck (30), and distant pain-free (44) analyses) and FEETH (head (39), neck (37), and distant pain-free (47) analyses) classifications. The funnel plot showed asymmetry in overall PPTs at the trigeminal area (Supplemental Figure 1) with a significant Egger’s test ( p = 0.0028); therefore, high risk of publication bias was possible, but mostly due to just one study (38). No evidence of publication bias for the results in the neck area was found (Supplemental Figure 2).…”

Section: Resultsmentioning

confidence: 99%

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Evidence of localized and widespread pressure pain hypersensitivity in patients with tension-type headache: A systematic review and meta-analysis

Fernández‐de‐las‐Peñas

Plaza‐Manzano

Navarro-Santana

et al. 2020

Cephalalgia

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Objective This meta-analysis evaluates pressure pain sensitivity values in symptomatic and distant pain-free areas comparing individuals with tension-type headache to controls. Databases and data treatment Electronic databases were searched for cross-sectional or prospective case-control studies comparing pressure pain thresholds in patients with tension-type headache to headache-free controls. Data were extracted by three reviewers. The methodological quality was assessed by the Newcastle-Ottawa Quality Assessment Scale. Meta-analyses of trigeminal, extra-trigeminal (neck) and distant pain-free areas in tension-type headache were compared to headache-free controls. Frequency of tension-type headache and gender were taken into account. Results Twenty studies were included. Patients with tension-type headache exhibited lower pressure pain thresholds than headache-free controls: Trigeminal (MD −49.11 kPa, 95% CI −66.05 to −32.17), cervical spine (MD −88.17 kPa, 95% CI −108.43 to −67.92) and distant pain-free areas (MD −98.43 kPa, 95% CI −136.78 to −60.09). Differences were significant for chronic, episodic, and mixed episodic and chronic tension-type headache within the trigeminal and neck (symptomatic areas), but only significant for chronic tension-type headache (MD −102.86, 95% CI −139.47 to −66.25 kPa) for distant pain-free areas. In general, women had lower pressure pain thresholds than men. The methodological quality ranged from fair (45%) to good (40%). The results showed a high heterogeneity and publication bias. Conclusion This first meta-analysis addressing pressure pain thresholds differences in symptomatic and distant pain-free areas between patients with tension-type headache and controls found low to moderate evidence supporting the presence of pressure pain hypersensitivity in the trigeminal and neck areas in tension-type headache in comparison with headache-free controls. Sensitivity to pressure pain was widespread only in chronic, not episodic, tension-type headache (moderate evidence). Registration number: https://doi.org/10.17605/OSF.IO/R29HY

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Evidence of localized and widespread pressure pain hypersensitivity in patients with tension-type headache: A systematic review and meta-analysis

Fernández‐de‐las‐Peñas

Plaza‐Manzano

Navarro-Santana

et al. 2020

Cephalalgia

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Neuronavigation based 10 sessions of repetitive transcranial magnetic stimulation therapy in chronic migraine: an exploratory study

et al. 2020

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Evaluation of serum uric levels in migraine

Yazar

Aygün

et al. 2020

Neurol Sci

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Objective In our study, the aim was to identify the serum uric acid levels, a marker of oxidative stress, according to migraine subtypes (aura/without aura and episodic/chronic migraine). Method The study included 300 migraine patients and 150 healthy controls for a total of 450 individuals. Migraine and subtypes were diagnosed according to International Classification of Headache Disorders-2013 criteria. Patients were evaluated during attendance at the neurology clinic. Results Our patient group was 77.0% female and disease duration was 9.2 ± 7.2 years. Our control group comprised 77.3% females. The age intervals in the patient and control groups were 36.4 ± 10.4 years and 36.0 ± 8.1 years. There was no statistically significant difference between our control and patient groups in terms of age and gender (p = .937 and p = .655). The serum UA, ferritin, and urea levels in our patient group were found to be significantly low compared to the healthy control group (p < .001). The serum UA levels in the migraine and control groups were 3.7 ± 0.7 and 4.6 ± 0.7 mg/dL, respectively (p < .001). There were no statistically significant differences observed between serum uric acid levels and other blood parameters between aura/without aura and episodic/chronic migraine subtypes (p > .05). Conclusion Our study supports the hypothesis that the oxidative stress marker of serum uric acid levels may be associated with migraine diagnosis, concluding that serum uric acid levels were not significant for migraine subtypes.

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Sensory function in headache: a comparative study among patients with cluster headache, migraine, tension-type headache, and asymptomatic subjects

Cited by 13 publications

References 37 publications

Evidence of localized and widespread pressure pain hypersensitivity in patients with tension-type headache: A systematic review and meta-analysis

Evidence of localized and widespread pressure pain hypersensitivity in patients with tension-type headache: A systematic review and meta-analysis

Neuronavigation based 10 sessions of repetitive transcranial magnetic stimulation therapy in chronic migraine: an exploratory study

Evaluation of serum uric levels in migraine

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