Sensory gating in neurodevelopmental disorders: A scoping review protocol

Abstract

Sensorimotor gating issues have been commonly reported in a number of neurodevelopmental disorders including autism spectrum disorder, attention-deficit/hyperactivity disorder, childhood-onset fluency disorder, and tic disorders. This review aims to explore the current understanding of sensorimotor gaiting in neurodevelopmental disorders as a possible transdiagnostic mechanism. We will apply methods according to the Joanna Briggs Institute Manual for Evidence Synthesis. We will follow the population, concept, and context scoping review eligibility criteria. Our population of interest includes individuals with neurodevelopmental disorders such as autism spectrum disorder, attention-deficit/hyperactivity disorder, childhood onset fluency disorder, and tic disorders as well as individuals from the general population who display traits associated with the disorders of interest. The concept of interest is sensorimotor gating defined as the automatic process of filtering out redundant or unnecessary sensory stimuli from environment. Finally, the context of this review is limited to human studies. Using a comprehensive search strategy in five relevant research databases (Medline, EMBASE, CINAHL, PsychInfo, and Scopus), we will search for relevant primary research articles and reviews that have been peer reviewed. Two independent reviewers will screen the titles and abstracts, full texts, and complete data extraction. Descriptive analyses will be used to summarize the characteristics and outcomes of all identified studies.

Prepulse Inhibition Deficit as a Transdiagnostic Process in Neuropsychiatric Disorders: A Systematic Review

“…The PPI de cit has been found in most of the thirteen psychopathological conditions that comprise the three groups of neuropsychiatric disorders included in this review. This result is in line with the wide variety of neuropsychiatric disorders in which a sensorimotor gating de cit has been reported in the scienti c literature [21,23,57], that goes beyond diagnostic boundaries and con rms its value as a possible transdiagnostic process [130], and as a translational research measure suitable for clinical practice [43]. Given the evidence that other sensorimotor gating measures, such as P50 suppression, have also been found to be altered in a wide range of psychopathological conditions [25,[131][132][133][134], it is not surprising that PPI de cit can be considered a transdiagnostic mechanism.…”

Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: a systematic review

“…The PPI deficit has been found in most of the eighteen psychopathological conditions that comprise the four groups of neuropsychiatric disorders included in this review. This result is in line with the wide variety of neuropsychiatric disorders in which a sensorimotor gating deficit has been reported in the scientific literature [ 21 , 26 , 68 ], that goes beyond diagnostic boundaries and supports its value as a possible transdiagnostic process [ 179 ], and as a translational research measure suitable for clinical practice [ 47 ]. Given the evidence that sensory gating measures, such as P50 suppression, have also been found to be altered in a wide range of psychopathological conditions [ 24 , 180 – 183 ], it is not surprising that PPI deficit can be proposed as a transdiagnostic mechanism.…”