Sensory Involvement in Amyotrophic Lateral Sclerosis

Rubio, Miguel Ángel; Herrando-Grabulosa, Mireia; Navarro, Xavier

doi:10.3390/ijms232415521

Cited by 16 publications

(14 citation statements)

References 330 publications

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“…52 These structural impairments in the somatosensory cortex and its related tracts may contribute to the abnormalities in processing and translating afferent sensory input that have been observed in patients with ALS. 53 In addition, we also observed increased ISO in the thalamic subregion connected to the occipital cortex and NDI reduction in the occipital cortex and thalamo-occipital tract. It has been observed that patients…”

Section: Discussionsupporting

confidence: 54%

“…Additionally, cortical thickness reduction in the somatosensory cortex and volume reductions in thalamic nuclei relaying somatosensory information have been observed in patients with ALS 52 . These structural impairments in the somatosensory cortex and its related tracts may contribute to the abnormalities in processing and translating afferent sensory input that have been observed in patients with ALS 53 . In addition, we also observed increased ISO in the thalamic subregion connected to the occipital cortex and NDI reduction in the occipital cortex and thalamo‐occipital tract.…”

Section: Discussionmentioning

confidence: 99%

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Neurite orientation dispersion and density imaging quantifies microstructural impairment in the thalamus and its connectivity in amyotrophic lateral sclerosis

Cao,

Wu,

Dong

et al. 2024

CNS Neurosci Ther

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AimsTo evaluate microstructural impairment in the thalamus and thalamocortical connectivity using neurite orientation dispersion and density imaging (NODDI) in amyotrophic lateral sclerosis (ALS).MethodsThis study included 47 healthy controls and 43 ALS patients, whose structural and diffusion‐weighted data were collected. We used state‐of‐the‐art parallel transport tractography to identify thalamocortical pathways in individual spaces. Thalamus was then parcellated into six subregions based on its connectivity pattern with the priori defined cortical (i.e., prefrontal/motor/somatosensory/temporal/posterior‐parietal/occipital) regions. For each of the thalamic and cortical subregions and thalamo‐cortical tracts, we compared the following NODDI metrics between groups: orientation dispersion index (ODI), neurite density index (NDI), and isotropic volume fraction (ISO). We also used these metrics to conduct receiver operating characteristic curve (ROC) analyses and Spearman correlation.ResultsIn ALS patients, we found decreased ODI and increased ISO in the thalamic subregion connecting the left motor cortex and other extramotor (e.g., somatosensory and occipital) cortex (Bonferroni‐corrected p < 0.05). NDI decreased in the bilateral thalamo‐motor and thalamo‐somatosensory tracts and in the right thalamo‐posterior‐parietal and thalamo‐occipital tracts (Bonferroni‐corrected p < 0.05). NDI reduction in the bilateral thalamo‐motor tract (p = 0.017 and 0.009) and left thalamo‐somatosensory tract (p = 0.029) was correlated with disease severity. In thalamo‐cortical tracts, NDI yielded a higher effect size during between‐group comparisons and a greater area under ROC (p < 0.05) compared with conventional diffusion tensor imaging metrics.ConclusionsMicrostructural impairment in the thalamus and thalamocortical connectivity is the hallmark of ALS. NODDI improved the detection of disrupted thalamo‐cortical connectivity in ALS.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Neurite orientation dispersion and density imaging quantifies microstructural impairment in the thalamus and its connectivity in amyotrophic lateral sclerosis

Cao,

Wu,

Dong

et al. 2024

CNS Neurosci Ther

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“…The increasing use of ultra-high field strength MRI scanners is expected to facilitate the reliable separation of glutamate signal from the glutamine signal [ 118 , 119 , 120 ]. The employment of a control region might have strengthened hippocampal findings, although increasing evidence from advanced neuroimaging literature suggests that regions previously known as unaffected are also affected and thorough clinical, neurophysiological and neuropsychological investigation may further provide anatomo-clinical associations (e.g., [ 121 , 122 , 123 ]). Notwithstanding these limitations, our study demonstrates the utility of MRS to examine non-motor brain regions in ALS and the metabolic substrate of specific cognitive domains.…”

Section: Discussionmentioning

confidence: 99%

Hippocampal Metabolic Alterations in Amyotrophic Lateral Sclerosis: A Magnetic Resonance Spectroscopy Study

Christidi

Argyropoulos

Karavasilis

et al. 2023

Life

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Background: Magnetic resonance spectroscopy (MRS) in amyotrophic lateral sclerosis (ALS) has been overwhelmingly applied to motor regions to date and our understanding of frontotemporal metabolic signatures is relatively limited. The association between metabolic alterations and cognitive performance in also poorly characterised. Material and Methods: In a multimodal, prospective pilot study, the structural, metabolic, and diffusivity profile of the hippocampus was systematically evaluated in patients with ALS. Patients underwent careful clinical and neurocognitive assessments. All patients were non-demented and exhibited normal memory performance. 1H-MRS spectra of the right and left hippocampi were acquired at 3.0T to determine the concentration of a panel of metabolites. The imaging protocol also included high-resolution T1-weighted structural imaging for subsequent hippocampal grey matter (GM) analyses and diffusion tensor imaging (DTI) for the tractographic evaluation of the integrity of the hippocampal perforant pathway zone (PPZ). Results: ALS patients exhibited higher hippocampal tNAA, tNAA/tCr and tCho bilaterally, despite the absence of volumetric and PPZ diffusivity differences between the two groups. Furthermore, superior memory performance was associated with higher hippocampal tNAA/tCr bilaterally. Both longer symptom duration and greater functional disability correlated with higher tCho levels. Conclusion: Hippocampal 1H-MRS may not only contribute to a better academic understanding of extra-motor disease burden in ALS, but given its sensitive correlations with validated clinical metrics, it may serve as practical biomarker for future clinical and clinical trial applications. Neuroimaging protocols in ALS should incorporate MRS in addition to standard structural, functional, and diffusion sequences.

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“…Amyotrophic lateral sclerosis (ALS) is a representative motor neuron disease in adults. Accumulated evidence, however, indicates that ALS is multisystem neuronal degeneration including the peripheral and central sensory pathways and sensory cortices [ 1 , 2 , 3 ]. Recent studies on the median nerve somatosensory evoked potentials (SEPs) reported that the early cortical components of the SEPs and their high-frequency oscillations (HFOs) were enlarged in patients with ALS [ 4 , 5 , 6 ], and that a high N20–P25 amplitude was an independent prognostic factor for short survival in ALS [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Sensory Gating during Voluntary Finger Movement in Amyotrophic Lateral Sclerosis with Sensory Cortex Hyperexcitability

Shimizu,

Nakayama,

Bokuda

et al. 2023

Brain Sciences

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Cortical responses in somatosensory evoked potentials (SEP) are enhanced in patients with amyotrophic lateral sclerosis (ALS). This study investigated whether sensory gating is involved in the pathophysiology of sensory cortical hyperactivity in ALS patients. The median nerve SEP was recorded at rest and during voluntary finger movements in 14 ALS patients and 13 healthy control subjects. The parietal N20, P25, and frontal N30 were analyzed, and sensory gating was assessed by measuring the amplitude of each component during finger movement. The amplitudes of the N20 onset–peak, N20 peak–P25 peak, and N30 onset–peak were higher in ALS patients than in controls. Nonetheless, there were no significant differences in the amplitude reduction ratio of SEPs between patients and controls. There was a significant correlation between the baseline amplitudes of the N20 onset–peak or N20 peak–P25 peak and their gating ratios in patients with ALS. Our findings indicate that the excitability of the primary sensory cortex and secondary motor cortex is enhanced in ALS, while sensory gating is preserved in the early stages of ALS. This result suggests that enhanced SEP is caused by the hyperexcitability of the primary sensory and secondary motor cortices but not by the dysfunction of inhibitory mechanisms during voluntary movements.

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Sensory Involvement in Amyotrophic Lateral Sclerosis

Cited by 16 publications

References 330 publications

Neurite orientation dispersion and density imaging quantifies microstructural impairment in the thalamus and its connectivity in amyotrophic lateral sclerosis

Neurite orientation dispersion and density imaging quantifies microstructural impairment in the thalamus and its connectivity in amyotrophic lateral sclerosis

Hippocampal Metabolic Alterations in Amyotrophic Lateral Sclerosis: A Magnetic Resonance Spectroscopy Study

Sensory Gating during Voluntary Finger Movement in Amyotrophic Lateral Sclerosis with Sensory Cortex Hyperexcitability

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