Sensory mismatch induces autonomic responses associated with hippocampal theta waves in rats

Aitake, Michiyo; Hori, Etsuro; Matsumoto, Jumpei; Umeno, Ken; Fukuda, Masaji; Ono, Taketoshi; Nishijo, Hisao

doi:10.1016/j.bbr.2011.02.011

Cited by 12 publications

(12 citation statements)

References 66 publications

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“…The present study provides additional evidence with respect to a role of the HD system in directional processing; the rodent HD system extracts different types of directional information (Figure 9) in different reference frames in a conflicting situation. The previous studies suggest the rats could adapt to backward translocation (Zou et al, 2009a; Aitake et al, 2011), and hippocampal neurons showed plastic changes in place fields after repeated experience of backward translocation in the same setup as in the present study (Zou et al, 2009b). The HD neurons reported in the present study might play important roles for spatial updating during the backward translocation.…”

Section: Discussionsupporting

confidence: 70%

“…However, it might be unlikely; first, the previous studies reported that although the backward movement increased hippocampal theta and sympathetic nervous activity, which corresponds to symptoms in motion sickness, the activity returned to the baseline level after repeated experience of this situation (Zou et al, 2009a; Aitake et al, 2011). This suggests that the rats could adapt to this situation.…”

Section: Discussionmentioning

confidence: 99%

“…In this backward translocation condition, idiothetic sensory inputs [visual (optic flow), vestibular inputs, and proprioceptive inputs or motor efferent copy] were mismatched; the proprioceptive inputs and/or motor efferent copy during locomotion (locomotion-related inputs) did not match the visual (optic flow)/vestibular inputs. Notably, although the rats showed increases in hippocampal theta power and sympathetic nervous activity, which is similar to symptoms in motion sickness (Zou et al, 2009a; Aitake et al, 2011), these changes returned to the baseline level after repeated exposure to the conflicting situation (Zou et al, 2009a; Aitake et al, 2011). These results suggest that the animals could adapt to this conflicting situation after repeated training, and that the rats could normally recognize the space in this condition.…”

Section: Introductionmentioning

confidence: 87%

“…The same apparatus as that in our previous papers (Dayawansa et al, 2006; Zou et al, 2009a,b; Aitake et al, 2011) was used. A stereotaxic apparatus with a transparent plastic enclosure for the semichronic recording (Nishijo and Norgren, 1990) and a treadmill were attached to the mobile stage (Figure 1A).…”

Section: Methodsmentioning

confidence: 99%

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Rat thalamic neurons encode complex combinations of heading and movement directions and the trajectory route during translocation with sensory conflict

Nyamdavaa

Matsumoto

Chinzorig

et al. 2014

Front. Behav. Neurosci.

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It is unknown how thalamic head direction neurons extract meaningful information from multiple conflicting sensory information sources when animals run under conditions of sensory mismatch. In the present study, rats were placed on a treadmill on a stage that moved in a figure-8-shaped pathway. The anterodorsal and laterodorsal neurons were recorded under two conditions: (1) control sessions, in which both the stage and the treadmill moved forward, or (2) backward (mismatch) sessions, in which the stage was moved backward while the rats ran forward on the treadmill. Of the 222 thalamic neurons recorded, 55 showed differential responses to the directions to window (south) and door (north) sides, along which the animals were translocated in the long axis of the trajectory. Of these 55 direction-related neurons, 15 showed heading direction-dependent responses regardless of movement direction (forward or backward movements). Thirteen neurons displayed heading and movement direction-dependent responses, and, of these 13, activity of 6 neurons increased during forward movement to the window or door side, while activity of the remaining 7 neurons increased during backward movement to the window or door side. Eighteen neurons showed movement direction-related responses regardless of heading direction. Furthermore, activity of some direction-related neurons increased only in a specific trajectory. These results suggested that the activity of these neurons reflects complex combinations of facing direction (landmarks), movement direction (optic flow/vestibular information), motor/proprioceptive information, and the trajectory of the movement.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 87%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Rat thalamic neurons encode complex combinations of heading and movement directions and the trajectory route during translocation with sensory conflict

Nyamdavaa

Matsumoto

Chinzorig

et al. 2014

Front. Behav. Neurosci.

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“…Until recently, there was no direct data regarding potential anatomical location of neurons generating “sensory mismatch” signal. In an elegant studies conducted in rats [41] demonstrated that this might happen in the hippocampus, whose role in spatial orientation and learning is well recognized. The first human brain imaging study of motion sickness revealed several regions that were activated during the experience of nausea, namely the medial prefrontal cortex, the insular cortex, the amygdala, the putamen and the locus coeruleus [42]; somewhat surprisingly, hippocampus was not among them.…”

Section: Discussionmentioning

confidence: 99%

Thermoregulatory correlates of nausea in rats and musk shrews

Ngampramuan

Cerri²,

Vecchio³

et al. 2014

Oncotarget

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Nausea is a prominent symptom and major cause of complaint for patients receiving anticancer chemo- or radiation therapy. The arsenal of anti-nausea drugs is limited, and their efficacy is questionable. Currently, the development of new compounds with anti-nausea activity is hampered by the lack of physiological correlates of nausea. Physiological correlates are needed because common laboratory rodents lack the vomiting reflex. Furthermore, nausea does not always lead to vomiting. Here, we report the results of studies conducted in four research centers to investigate whether nausea is associated with any specific thermoregulatory symptoms. Two species were studied: the laboratory rat, which has no vomiting reflex, and the house musk shrew (Suncus murinus), which does have a vomiting reflex. In rats, motion sickness was induced by rotating them in their individual cages in the horizontal plane (0.75 Hz, 40 min) and confirmed by reduced food consumption at the onset of dark (active) phase. In 100% of rats tested at three centers, post-rotational sickness was associated with marked (~1.5°C) hypothermia, which was associated with a short-lasting tail-skin vasodilation (skin temperature increased by ~4°C). Pretreatment with ondansetron, a serotonin 5-HT3 receptor antagonist, which is used to treat nausea in patients in chemo- or radiation therapy, attenuated hypothermia by ~30%. In shrews, motion sickness was induced by a cyclical back-and-forth motion (4 cm, 1 Hz, 15 min) and confirmed by the presence of retching and vomiting. In this model, sickness was also accompanied by marked hypothermia (~2°C). Like in rats, the hypothermic response was preceded by transient tail-skin vasodilation. In conclusion, motion sickness is accompanied by hypothermia that involves both autonomic and thermoeffector mechanisms: tail-skin vasodilation and possibly reduction of the interscapular brown adipose tissue activity. These thermoregulatory symptoms may serve as physiological correlates of nausea.

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Motion sickness-susceptible participants exposed to coherent rotating dot patterns show excessive N2 amplitudes and impaired theta-band phase synchronization

Wei

Okazaki

et al. 2019

NeuroImage

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Sensory mismatch induces autonomic responses associated with hippocampal theta waves in rats

Cited by 12 publications

References 66 publications

Rat thalamic neurons encode complex combinations of heading and movement directions and the trajectory route during translocation with sensory conflict

Rat thalamic neurons encode complex combinations of heading and movement directions and the trajectory route during translocation with sensory conflict

Thermoregulatory correlates of nausea in rats and musk shrews

Motion sickness-susceptible participants exposed to coherent rotating dot patterns show excessive N2 amplitudes and impaired theta-band phase synchronization

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