Sensory Nerve Conduction Studies in the Diagnosis of Diabetic Sensorimotor Polyneuropathy: Electrophysiological Features

Kang, Ji-Hyuk; Lee, Yoon-Seob

doi:10.1589/jpts.24.139

Cited by 5 publications

(5 citation statements)

References 24 publications

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“…Patients with ulnar nerve entrapment neuropathy of the elbow require attention and are investigated because of pain. Early diagnosis, correct classification and understanding of the mechanisms underlying pain are needed to decide the appropriate treatment 11 ) . The International Association for the Study of Pain (IASP) defines neuropathic pain as a pain induced by dysfunction in or damage to the nervous system 12 ) .…”

Section: Discussionmentioning

confidence: 99%

Ulnar nerve entrapment neuropathy at the elbow: relationship between the electrophysiological findings and neuropathic pain

et al. 2015

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[Purpose] Ulnar nerve neuropathies are the second most commonly seen entrapment neuropathies of the upper extremities after carpal tunnel syndrome. In this study, we aimed to evaluate pain among ulnar neuropathy patients by the Leeds assessment of neuropathic symptoms and signs pain scale and determine if it correlated with the severity of electrophysiologicalfindings. [Subjects and Methods] We studied 34 patients with clinical and electrophysiological ulnar nerve neuropathies at the elbow. After diagnosis of ulnar neuropathy at the elbow, all patients underwent the Turkish version of the Leeds assessment of neuropathic symptoms and signs pain scale. [Results] The ulnar entrapment neuropathy at the elbow was classified as class-2, class-3, class-4, and class-5 (Padua Distal Ulnar Neuropathy classification) for 15, 14, 4, and 1 patient, respectively. No patient included in class-1 was detected. According to Leeds assessment of neuropathic symptoms and signs pain scale, 24 patients scored under 12 points. The number of patients who achieved more than 12 points was 10. Groups were compared by using the χ2 test, and no difference was detected. There was no correlation between the Leeds assessment of neuropathic symptoms and signs pain scale and electromyographic findings. [Conclusion] We found that the severity of electrophysiologic findings of ulnar nerve entrapment at the elbow did not differ between neuropathic and non-neuropathic groups as assessed by the Leeds assessment of neuropathic symptoms and signs pain scale.

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Section: Discussionmentioning

confidence: 99%

Ulnar nerve entrapment neuropathy at the elbow: relationship between the electrophysiological findings and neuropathic pain

et al. 2015

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“…The diagnosis of DPN included evaluations of the clinical symptom history, a neurological examination, electrophysiological tests, quantitative sensory testing, and autonomic function tests. The diagnoses were based on clinical symptoms and the results of the entire electromyography 8 , 9 , 10 ) . Medical data were documented.…”

Section: Methodsmentioning

confidence: 99%

The association of vitamin D with inflammatory cytokines in diabetic peripheral neuropathy

et al. 2016

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[Purpose] The effects of vitamin D on the circulating levels of IL-17 and IL-13 were investigated in patients with diabetic peripheral neuropathy, patients with diabetes mellitus type 2 without neuropathy, and healthy controls. [Subjects and Methods] A single-blind controlled clinical study was performed, including70 type 2 diabetic patients with or without diabetic peripheral neuropathy and 33 healthy volunteer controls. The 25(OH)D levels were evaluated using ultra-performance liquid chromatography, and IL-17 and IL-13 levels were assessed using enzyme-linked immunosorbent assays. [Results] The 25(OH) vitamin D concentration was lower in diabetic peripheral neuropathy patients than in diabetes mellitus patients without neuropathy and healthy controls. Similarly, 25(OH)D levels were lower in diabetes mellitus patients than healthy controls. IL-17 and IL-13 levels were higher in diabetes mellitus patients than in controls. Additionally, IL-13 levels were higher in diabetic peripheral neuropathy patients than in diabetes mellitus patients without neuropathy. These differences were statistically significant. There was a significant positive correlation between 25(OH)D and IL-13,and a negative correlation between 25(OH)D andIL-17 in the diabetic and diabetic neuropathy groups. [Conclusion] Vitamin D is a potential modifiable risk factor for diabetic peripheral neuropathy and may regulate inflammatory mediators, e.g., IL-17 and IL-13.

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“…The prevalence in patients suffering from diabetic polyneuropathy varies from 23 to 29% 2 ) . The presence of neurological symptoms and/or signs in electroneurographic (ENG) findings is necessary for confirming the diagnosis of distal sensorimotor diabetic polyneuropathy (DSMP) 3 , 4 ) . Slow sensitivity and motor velocity of conduction exists in clinically evident neuropathy, especially in the feet, where the peripheral nerves are the longest.…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of the effects combined physical procedures and alpha-lipoic acid on the electroneurographic parameters of patients with distal sensorimotor diabetic polyneuropathy

et al. 2016

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[Purpose] Painful diabetic polyneuropathy occurs as a complication in 16% of all patients with diabetes mellitus. [Subjects and Methods] A clinical, prospective open-label randomized intervention study was conducted of 60 adult patients, with distal sensorimotor diabetic neuropathy two groups of 30 patients, with diabetes mellitus type 2 with distal sensorimotor diabetic neuropathy. Patients in group A were treated with combined physical procedures, and patients in group B were treated with alpha lipoic acid. [Results] There where a statistically significant improvements in terminal latency and the amplitude of the action potential in group A patients, while group B patients showed a statistically significant improvements in conduction velocity and terminal latency of n. peroneus. Group A patients showed a statistically significant improvements in conduction velocity and terminal latency, while group B patients also showed a statistically significant improvements in conduction velocity and terminal latency. This was reflected in a significant improvements in electrophysiological parameters (conduction velocity, amplitude and latency) of the motor and sensory nerves (n. peroneus, n. suralis). [Conclusion] These results present further evidence justifying of the use of physical agents in the treatment of diabetic sensorimotor polyneuropathy.

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Sensory Nerve Conduction Studies in the Diagnosis of Diabetic Sensorimotor Polyneuropathy: Electrophysiological Features

Cited by 5 publications

References 24 publications

Ulnar nerve entrapment neuropathy at the elbow: relationship between the electrophysiological findings and neuropathic pain

Ulnar nerve entrapment neuropathy at the elbow: relationship between the electrophysiological findings and neuropathic pain

The association of vitamin D with inflammatory cytokines in diabetic peripheral neuropathy

Comparative analysis of the effects combined physical procedures and alpha-lipoic acid on the electroneurographic parameters of patients with distal sensorimotor diabetic polyneuropathy

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