Sensory Neuron Degeneration in Pigs

Wintrobe, M. M.; Miller, Mitchell H.; Follis, Richard H.; Stein, Harold J.; Mushatt, Cecil; Humphreys, Stewart R.

doi:10.1093/jn/24.4.345

Cited by 54 publications

(3 citation statements)

References 9 publications

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“…Full details of the experimental methods have been described elsewhere (3). When the pigs were received in the laboratory they were placed on the basal diet: Sheffeld "new process" casein, 26.1 per cent; sucrose, 57.7 per cent; lard, 11 per cent; salt mixture, 5.2 per cent, and Mead's blended oil.…”

Section: Methodsmentioning

confidence: 99%

A Comparison of the Effects of Pyridoxine and Pantothenic Acid Deficiencies on the Nervous Tissues of Swine

Follis

Wintrobe

1945

Journal of Experimental Medicine

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1. When pigs were fed diets deficient in pyridoxine or pantothenic acid, ataxia developed and lesions were found in the sensory neuron. 2. The morphological pattern of the lesions differed in the early stages of the two deficient states. Degeneration of the peripheral process of the sensory neuron was the initial and most prominent feature in pyridoxine deficiency. Chromatolysis was the first evidence of damage to the afferent neuron in pantothenic acid-deficient animals. 3. The possible significance of this evidence of damage to different portions of the sensory neuron is discussed.

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Section: Methodsmentioning

confidence: 99%

A Comparison of the Effects of Pyridoxine and Pantothenic Acid Deficiencies on the Nervous Tissues of Swine

Follis

Wintrobe

1945

Journal of Experimental Medicine

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“…Briefly restated, the degrees of degeneration are classified as follows: Objects. (1) To gain further evidence regarding the protective value of whole desiccated liver and of brewers' yeast; (2) to determine whether the protective substance is present in wheat germ and alfalfa; (3) to obtain preliminary information regarding the protective value of the antipernicious anemia fraction of liver.…”

mentioning

confidence: 99%

“…It should be pointed out that all the animals described here except those given yeast throughout the experiment received supplements of thiamin alone or thiamin, riboflavin and nicotinic acid in view is given. Mitchell fed the salt mixture described in our preliminary experiments (1), not that used in later studies (2) …”

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confidence: 99%

The Prevention of Sensory Neuron Degeneration in the Pig, With Special Reference to the Rôle of Various Liver Fractions 1

Wintrobe¹,

Mushatt²,

Kolb³

et al. 1942

J. Clin. Invest.

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In previous reports (1, 2) a description was given of abnormal gait and degeneration in the nervous system which developed in pigs under certain experimental conditions. It was suggested that these effects were the result of a dietary deficiency and evidence was presented which indicated that the changes took place in spite of adequate amounts of vitamin A, thiamin, riboflavin, nicotinic acid or vitamin E. Inanition or mineral deficiency did not seem to play any role. It was shown that a nerve-protecting factor was present in liver and, to a lesser extent, in yeast.In an attempt to discover the nature of this protective factor or factors, further experiments have been carried out in which the basal deficient diet has been supplemented by various crude sources of accessory factors, chiefly various fractions of liver. More recently the newer vitamins, pyridoxine, pantothenic acid and choline have been used in conjunction with thiamin, riboflavin and nicotinic acid. It is the purpose of this report to give an account of the observations dealing with crude substances. Particular interest attaches to the nerve-protecting value of different fractions of liver, for degeneration similar to that observed in the pigs occurs in many cases of pernicious anemia in man. The fractions of liver used were those I

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Relation of Nutritional Deficiency to Cardiac Dysfunction

Wintrobe¹

1945

Arch Intern Med

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Sensory Neuron Degeneration in Pigs

Cited by 54 publications

References 9 publications

A Comparison of the Effects of Pyridoxine and Pantothenic Acid Deficiencies on the Nervous Tissues of Swine

A Comparison of the Effects of Pyridoxine and Pantothenic Acid Deficiencies on the Nervous Tissues of Swine

The Prevention of Sensory Neuron Degeneration in the Pig, With Special Reference to the Rôle of Various Liver Fractions 1

Relation of Nutritional Deficiency to Cardiac Dysfunction

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