2022
DOI: 10.1101/2022.07.19.500657
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Sensory neurons safeguard from mutational inheritance by controlling the CEP-1/p53-mediated DNA damage response in primordial germ cells

Abstract: The genome integrity control in primordial germ cells (PGCs) is prerequisite for the inheritance of stable genomes. The PGCs in C. elegans are embedded in a somatic niche that regulates its DNA damage response (DDR). Here, we show that the AMPK-like kinases KIN-29 and AAK-2 are required for arresting PGCs carrying persistent DNA damage. We determined that the ASI neurons, which sense environmental conditions such as nutrient availability, secrete the TGF-beta-like ligand DAF-7 that is recognized by the DAF-1 r… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
references
References 60 publications
0
0
0
Order By: Relevance