Sensory phenomena: Clinical correlates and impact on quality of life in adult patients with Tourette syndrome

Histaminergic modulation in Tourette syndrome

“…Interestingly, tics are characteristically preceded by subjective urges which are relieved by tic expression and can be resisted only for a limited length of time, at the expense of mounting inner tension [7][8][9][10][11][12]. According to the DSM-5, diagnostic criteria for TS focus on the presence of multiple motor tics plus at least one vocal tic, with onset before the age of 18 years and lasting for over a year [13].…”

Sensory phenomena related to tics, obsessive-compulsive symptoms, and global functioning in Tourette syndrome

“…ACCEPTED MANUSCRIPT 17 number, intensity, complexity, and interference. Both the USP-SPS total scores and the PUTS total scores were significantly correlated with the YGTSS vocal tics scores but not with the motor tic scores.…”

“…In adults with TS, premonitory urges are significantly correlated with the quality of life (QOL) psychological domain 17 . Furthermore, a strong negative correlation has been revealed between premonitory urges and QOL in patients with TS without comorbid conditions.…”

Functional neuroimaging in Tourette syndrome: recent perspectives

“…3 PUTS has been found to have a significant correlation with tic severity and quality of life. 4 Furthermore, premonitory urge plays a role in the more recent behavioral therapies used in the treatment of TS. 5 TS is often accompanied by other symptoms.…”