Sensory Processing and Ionic Currents in Vestibular Hair Cells

Steinacker, A.

doi:10.1007/0-387-21567-0_5

Cited by 3 publications

(3 citation statements)

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“…Thus shorter and stiffer stereocilia should resonate at a higher frequency (Fettiplace and Fuchs 1999). The electrical tuning of a hair cell is determined by the number of potassium (K + ) channels (Fettiplace and Fuchs 1999; Steinacker 2004). The cell’s resonant frequency is correlated with the number of K + channels, with more channels producing a higher resonant frequency (Fettiplace and Fuchs 1999; Steinacker 2004).…”

Section: Discussionmentioning

confidence: 99%

“…The electrical tuning of a hair cell is determined by the number of potassium (K + ) channels (Fettiplace and Fuchs 1999; Steinacker 2004). The cell’s resonant frequency is correlated with the number of K + channels, with more channels producing a higher resonant frequency (Fettiplace and Fuchs 1999; Steinacker 2004). Thus, the term “resonant frequency” or perhaps “best frequency” may be the most accurate term to use when describing the effects of stimulus frequency on the vestibular system.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Age on the Tuning of the cVEMP and oVEMP

et al. 2013

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SHORT SUMMARY The purpose of this investigation was to define the best frequency, or frequencies, to record the cVEMP and oVEMP and to describe age-related changes in VEMP tuning. Subjects demonstrated a range of best frequencies. Compared to younger subjects, older subjects demonstrated a shift to higher best frequencies. Accordingly, 500 Hz may not be the ideal frequency to elicit VEMPs for all age groups. For this reason in cases where the VEMP response is absent at 500 Hz we recommend that attempts be made to record the VEMP for tone burst frequencies of 750 Hz and/or 1000 Hz.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of Age on the Tuning of the cVEMP and oVEMP

et al. 2013

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“…For example, the transition from water to land-based life has resulted in major changes in the natural sensory environment since the resistive hydrodynamic forces of an aquatic environment effectively dampen self-motion [ 27 ]. In addition, the longer and more flexible necks of amniotes can cause faster head movements [ 28 ]. Together, these factors suggest that terrestrial amniotes generally experience stimulation at higher amplitudes compared to mostly neckless fish or amphibian species.…”

Section: Animal Models and Major Topics In Vestibular Researchmentioning

confidence: 99%

Vestibular animal models: contributions to understanding physiology and disease

2016

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Our knowledge of the vestibular sensory system, its functional significance for gaze and posture stabilization, and its capability to ensure accurate spatial orientation perception and spatial navigation has greatly benefitted from experimental approaches using a variety of vertebrate species. This review summarizes the attempts to establish the roles of semicircular canal and otolith endorgans in these functions followed by an overview of the most relevant fields of vestibular research including major findings that have advanced our understanding of how this system exerts its influence on reflexive and cognitive challenges encountered during daily life. In particular, we highlight the contributions of different animal models and the advantage of using a comparative research approach. Cross-species comparisons have established that the morpho-physiological properties underlying vestibular signal processing are evolutionarily inherent, thereby disclosing general principles. Based on the documented success of this approach, we suggest that future research employing a balanced spectrum of standard animal models such as fish/frog, mouse and primate will optimize our progress in understanding vestibular processing in health and disease. Moreover, we propose that this should be further supplemented by research employing more “exotic” species that offer unique experimental access and/or have specific vestibular adaptations due to unusual locomotor capabilities or lifestyles. Taken together this strategy will expedite our understanding of the basic principles underlying vestibular computations to reveal relevant translational aspects. Accordingly, studies employing animal models are indispensible and even mandatory for the development of new treatments, medication and technical aids (implants) for patients with vestibular pathologies.

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The Increased Sensitivity of Irregular Peripheral Canal and Otolith Vestibular Afferents Optimizes their Encoding of Natural Stimuli

Schneider¹,

Jamali

Carriot

et al. 2015

J. Neurosci.

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Efficient processing of incoming sensory input is essential for an organism's survival. A growing body of evidence suggests that sensory systems have developed coding strategies that are constrained by the statistics of the natural environment. Consequently, it is necessary to first characterize neural responses to natural stimuli to uncover the coding strategies used by a given sensory system. Here we report for the first time the statistics of vestibular rotational and translational stimuli experienced by rhesus monkeys during natural (e.g., walking, grooming) behaviors. We find that these stimuli can reach intensities as high as 1500 deg/s and 8 G. Recordings from afferents during naturalistic rotational and linear motion further revealed strongly nonlinear responses in the form of rectification and saturation, which could not be accurately predicted by traditional linear models of vestibular processing. Accordingly, we used linear-nonlinear cascade models and found that these could accurately predict responses to naturalistic stimuli. Finally, we tested whether the statistics of natural vestibular signals constrain the neural coding strategies used by peripheral afferents. We found that both irregular otolith and semicircular canal afferents, because of their higher sensitivities, were more optimized for processing natural vestibular stimuli as compared with their regular counterparts. Our results therefore provide the first evidence supporting the hypothesis that the neural coding strategies used by the vestibular system are matched to the statistics of natural stimuli.

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Sensory Processing and Ionic Currents in Vestibular Hair Cells

Cited by 3 publications

References 93 publications

Effects of Age on the Tuning of the cVEMP and oVEMP

Effects of Age on the Tuning of the cVEMP and oVEMP

Vestibular animal models: contributions to understanding physiology and disease

The Increased Sensitivity of Irregular Peripheral Canal and Otolith Vestibular Afferents Optimizes their Encoding of Natural Stimuli

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