Sensory Processing and Sensorimotor Integration in Migraine

Boran, H. Evren; Bolay, Hayrünnisa; Gantenbein, H. Andreas R.; Pohl, Heiko

doi:10.1007/978-3-030-56538-1_9

Cited by 5 publications

(9 citation statements)

References 131 publications

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“…Our results show an unusual RSEC between the PAG and right postcentral gyrus and the left precentral gyrus, which belong to the primary sensorimotor cortex. 17 The primary sensorimotor cortex plays a key role in the processing and integration of somatosensory information and is involved in the development and maintenance of migraines. 17 Compared with controls, individuals with migraine and insomnia showed regional gray matter volume changes in the precentral and postcentral gyrus.…”

Section: Discussionmentioning

confidence: 99%

“…17 The primary sensorimotor cortex plays a key role in the processing and integration of somatosensory information and is involved in the development and maintenance of migraines. 17 Compared with controls, individuals with migraine and insomnia showed regional gray matter volume changes in the precentral and postcentral gyrus. 18 Participants with MwoA also exhibited increased fractional 3.…”

Section: Discussionmentioning

confidence: 99%

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Abnormally Increased Effective Connectivity of the Periaqueductal Gray in Migraine Without Aura Patients

Liu

Cheng²,

Cao

et al. 2023

The Clinical Journal of Pain

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Objectives: The periaqueductal gray (PAG) is a key region in the descending pain modulatory system. We applied a Granger causality analysis-based approach to examine resting-state effective connectivity of the bilateral PAG regions in migraine patients without aura (MwoA).Materials and Methods: Resting-state functional magnetic resonance imaging data were obtained from 28 MwoA patients and 17 healthy controls. The effective connectivity of the bilateral PAG was characterized using a voxel-wised Granger causality analysis method. The resulting effective connectivity measurements were assessed for correlations with other clinical features.Results: Compared with the healthy controls, MwoA patients showed increased effective connectivity from the left PAG to the left anterior cingulate gyrus and right postcentral gyrus. Meanwhile, MwoA patients also showed increased effective connectivity from the right PAG to the left precentral gyrus and increased effective connectivity from the left caudate and right middle occipital gyrus to the right PAG.Discussion: Abnormally increased effective connectivity between PAG and limbic system, primary sensorimotor cortex, and visual cortex may play a key role in neuropathological features, perception, and affection of MwoA. The current study provides further insights into the complex scenario of MwoA mechanisms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Abnormally Increased Effective Connectivity of the Periaqueductal Gray in Migraine Without Aura Patients

Liu

Cheng²,

Cao

et al. 2023

The Clinical Journal of Pain

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“…[4] PET and functional MRI studies have shown that brainstem is activated during migraine attacks. [5] Current hypotheses associate primary dysfunction with brainstem centers that regulate vascular tension and sense of pain. The blood vessels and cerebrospinal membranes in the skull, particularly pain-sensitive structures such as the dura mater, are fed by the ophthalmic branch of the first branch of the trigeminal nerve with sensory nerve fibers.…”

Section: Pathophysiology Of Migrainementioning

confidence: 99%

Migraine and Calcitonin Gene-Related Peptide Receptor Antagonist Treatment

Akbaş

2020

JEB Med Sci

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Migraine is one of the primary causes of headache that reduces people's quality of life and work force, mostly affecting young and middle-aged individuals. Although many treatment options have been put forward, the treatment is still not satisfactory for many patients today. CRGP is a peptide neurotransmitter produced in numerous regions in the central nervous system. It takes part in communication between nerve cells and enables the vessels to expand, especially in areas where the need for blood increases in the brain. This vein expander triggers headaches in migraine patients, causing the body to react abnormally. Because CGRP is an important molecule for the brain to function in its normal order, there has been success in treatments done by shutting down its receptors rather than completely neutralizing them in the body. Selective CGRP receptor antagonists should be effective antimigrene drugs.

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“…Auras are transient neurological deficits that occur in 20% of the cases, usually before (sometimes after) a headache, and gradually increase in severity within five minutes. Harold G Wolff suggests aura symptoms relate to cerebral vasoconstriction and headaches to cerebral vasodilation (2). In addition to positive visual symptoms, such as zigzag patterns and photopsia, and negative visual symptoms, such as hemianopsia and quadrantopsia, unilateral DOI: 10.37990/medr.1192019 positive or negative somatosensory pictures and less common speech/language disorders can appear as the aura.…”

Section: Introductionmentioning

confidence: 99%

“…There are many subtypes according to the symptoms seen. Despite many studies on migraine pathophysiology, there is still no consensus (1)(2)(3)(4)(5)(6)(7). Research on the aura mechanism has focused on cortical spreading depression and changes in brain structures (2).…”

Section: Introductionmentioning

confidence: 99%

Retrospective Investigation of Brainstem Volume and Craniovertebral Junction Morphometry in Migraine Patients

et al. 2023

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Aim: Migraine, a complex, multifactorial neurovascular brain disorder, might cause several functional and morphometric changes in the brain. Despite many studies, a consensus has not emerged on its pathophysiology, and it is not fully elucidated so far. Recently, changing brain structures in migraine with aura has been attracting the attention of the scientific periphery. The brainstem is a critical region in the pathogenesis of migraine. Another transition point is the craniovertebral junction. Regional pathologies might trigger off the pathogenesis of neurodegenerative and neurological diseases by affecting hydrodynamics. Moreover, there is insufficient data on the relationship of migraine with the craniovertebral junction. The present study aimed to make the volumetric analysis of brainstem volume in migraine with and without aura, perform some angular and linear measurements of the craniovertebral junction, and evaluate the effects of these parameters in migraine patients. Material and method: The study retrospectively analyzed the brain Magnetic Resonance Images of 108 migraine patients (aged 18 to 65). Their brainstem volumes were measured using volBrain. Also, the angular and linear parameters of craniovertebral junctions were derived from the images. The obtained data were transferred to the SPSS 22 package program and analyzed. Results: The mean brainstem volume was 17.21±2.79 cm3 in the migraine with aura group, 17.33±2.48 cm3 in the migraine without aura, and 19.27±2.76 cm3 in the control group. There was no statistically significant difference between migraine with and without aura groups (p>0.05). There was a statistically significant difference between the control and both migraine groups (p

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Sensory Processing and Sensorimotor Integration in Migraine

Cited by 5 publications

References 131 publications

Abnormally Increased Effective Connectivity of the Periaqueductal Gray in Migraine Without Aura Patients

Abnormally Increased Effective Connectivity of the Periaqueductal Gray in Migraine Without Aura Patients

Migraine and Calcitonin Gene-Related Peptide Receptor Antagonist Treatment

Retrospective Investigation of Brainstem Volume and Craniovertebral Junction Morphometry in Migraine Patients

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