Sensory Processing in Rhesus Monkeys: Developmental Continuity, Prenatal Treatment, and Genetic Influences

Schneider, Mary L.; Moore, Colleen F.; Adkins, Miriam M.; Barr, Christina S.; Larson, Julie A.; Resch, Leslie M.; Roberts, Andrew

doi:10.1111/cdev.12572

Cited by 9 publications

(8 citation statements)

References 84 publications

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“…Probably due to the small sample used in this research, this study has not yielded statistically significant differences between children who have suffered from a stressful/traumatic pregnancy and tactile and auditory sensory processing, expected results following the findings obtained by Keuler et al [24], who drew a relationship between prenatal complications and problems of auditory and tactile hyperreactivity. These results [30] are a finding compatible with the research of Schneider et al [11] in rhesus monkeys, thus suggesting that prenatal maternal stress increases babies' tactile sensitivity, and the study by Heuvel, Donkers, Winkler, Otte & Van Der Bergh [25], which indicates that greater maternal anxiety could be interpreted as a reflection of weaker habituation to auditory stimuli in these babies, thus indicating less adaptive brain functioning.…”

Section: Resultssupporting

confidence: 91%

Predictive Factors for Sensory Processing Disorders

B¹,

L²,

R³

et al. 2021

physmedrehabilint

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Background: Identifying sensory processing differences in children with sensory reactivity problems (both with and without prenatal and perinatal problems) is essential to providing interventions that enhance development and participation in everyday life. Methods: This study conducted a statistical analysis between the Sensory Profile-2 sensory questionnaire and the study variables: pregnancy, fertility treatment, delivery and prematurity (n=69). Results: This study yielded statistically significant differences in sensory processing at the visual level (p-value=0.003), in proprioception (body position) (p-value<0.001) and in emotional problems relating to stressful and traumatic pregnancy, prematurity (p-value=0.026) and high-risk pregnancy, respectively, among children with and without perinatal and prenatal problems. Conclusions: These findings confirm that there are differences in the sensory processing of children with sensory processing disorders who have suffered perinatal and postnatal problems compared to those who have not.

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Section: Resultssupporting

confidence: 91%

Predictive Factors for Sensory Processing Disorders

B¹,

L²,

R³

et al. 2021

physmedrehabilint

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“…These females were then randomly assigned to consume alcohol during specific gestation periods, alone or in combination with mild prenatal stress exposure, compared with randomly assigned controls. We did not include the prenatal treatment findings in this paper because they have been reported elsewhere (Schneider et al, 2008a, 2009, 2017; Converse et al, 2013, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…We were particularly interested in PFC and striatum and their sub-regions because of their critical role in organizing complex cognitive function and translating stimulus properties into adaptive behavior, as well as midbrain, the location of DA cell bodies. In this paper we examined the relationships of ligand binding to our findings from the SPS-M (Schneider et al, 2008b), concentrating on brain regions that had shown effects of DA in our previous work (Schneider et al, 2008a, 2017; Converse et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

PET Measures of D1, D2, and DAT Binding Are Associated With Heightened Tactile Responsivity in Rhesus Macaques: Implications for Sensory Processing Disorder

Schneider

Moore

Ahlers

et al. 2019

Front. Integr. Neurosci.

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Sensory processing disorder (SPD), a developmental regulatory condition characterized by marked under- or over-responsivity to non-noxious sensory stimulation, is a common but poorly understood disorder that can profoundly affect mood, cognition, social behavior and adaptive life skills. Little is known about the etiology and neural underpinnings. Clinical research indicates that children with SPD show greater prevalence of difficulties in complex cognitive behavior including working memory, behavioral flexibility, and regulation of sensory and affective functions, which are related to prefrontal cortex (PFC), striatal, and midbrain regions. Neuroimaging may provide insight into mechanisms underlying SPD, and animal experiments provide important evidence that is not available in human studies. Rhesus monkeys ( N = 73) were followed over a 20-year period from birth into old age. We focused on a single sensory modality, the tactile system, measured at 5–7 years, because of its critical importance for nourishment, attachment, and social reward in development. Positron emission tomography imaging was conducted at ages 12–18 years to quantify the availability of the D1 and D2 subtypes of the DA receptor (D1R and D2R), and the DA transporter (DAT). Heightened tactile responsivity was related to (a) elevated D1R in PFC overall, including lateral, ventrolateral, medial, anterior cingulate (aCg), frontopolar, and orbitofrontal (OFC) subregions, as well as nucleus accumbens (Acb), (b) reduced D2R in aCg, OFC, and substantia nigra/ventral tegmental area, and (c) elevated DAT in putamen. These findings suggest a mechanism by which DA pathways may be altered in SPD. These pathways are associated with reward processing and pain regulation, providing top-down regulation of sensory and affective processes. The balance between top-down cognitive control in the PFC-Acb pathway and bottom-up motivational function of the VTA-Acb-PFC pathway is critical for successful adaptive function. An imbalance in these two systems might explain DA-related symptoms in children with SPD, including reduced top-down regulatory function and exaggerated responsivity to stimuli. These results provide more direct evidence that SPD may involve altered DA receptor and transporter function in PFC, striatal, and midbrain regions. More work is needed to extend these results to humans.

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“…In primate models, certain genes (e.g. the short serotonin transporter gene polymorphic region variation [rh5‐HTTLPR]), an allele with a functional analog in humans) increase the likelihood of developing sensory [163], stress and irritability [164] disorders secondary to alcohol. As noted previously, genes that code for alcohol dehydrogenase polymorphisms may affect drinking behavior or alcohol metabolism, impacting on the amount of maternal alcohol reaching the fetus [165].…”

Section: Fetal Alcohol Spectrum Disorder (Fasd)mentioning

confidence: 99%

Alcohol use in pregnancy and its impact on the mother and child

Oei

2020

Addiction

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Aims To review the impact of prenatal alcohol exposure on the outcomes of the mother and child. Design Narrative review. Setting Review of literature. Participants Mothers and infants affected by prenatal alcohol use. Measurements Outcomes of mothers and children. Findings Prenatal alcohol exposure is one of the most important causes of preventable cognitive impairment in the world. The developing neurological system is exquisitely sensitive to harm from alcohol and there is now also substantial evidence that alcohol-related harm can extend beyond the individual person, leading to epigenetic changes and intergenerational vulnerability and disadvantage. There is no known safe level or timing of drinking for pregnant or lactating women and binge drinking (> four drinks within 2 hours for women) is the most harmful. Alcohol-exposure increases the risk of congenital problems, including Fetal Alcohol Spectrum Disorder (FASD) and its most severe form, Fetal Alcohol Syndrome (FAS). Conclusion The impact of FASD and FAS is enduring and lifelong with no current treatment or cure. Emerging therapeutic options may mitigate the worst impact of alcohol exposure but significant knowledge gaps remain. This review discusses the history, epidemiology and clinical presentations of prenatal alcohol exposure, focusing on FASD and FAS, and the impact of evidence on future research, practice and policy directions.

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Sensory Processing in Rhesus Monkeys: Developmental Continuity, Prenatal Treatment, and Genetic Influences

Cited by 9 publications

References 84 publications

Predictive Factors for Sensory Processing Disorders

Predictive Factors for Sensory Processing Disorders

PET Measures of D1, D2, and DAT Binding Are Associated With Heightened Tactile Responsivity in Rhesus Macaques: Implications for Sensory Processing Disorder

Alcohol use in pregnancy and its impact on the mother and child

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