Sensory sensitivity after acquired brain injury: A systematic review

Thielen, Hella; Tuts, Nora; Welkenhuyzen, Lies; Wajer, Irene M.C. Huenges; Lafosse, Christophe; Gillebert, Céline R.

doi:10.1111/jnp.12284

Cited by 19 publications

(12 citation statements)

References 142 publications

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“…This condition is particularly prevalent in individuals with acquired brain injuries, where the conventional processing of sensory information is disrupted [ 63 ]. Such disruptions lead to altered perceptions that significantly influence daily living and functional recovery [ 64 , 65 ]. The heightened sensory input associated with spasticity-related unpleasant sensations may overwhelm the individual’s sensory processing capabilities, leading to a state of sensory overload.…”

Section: Discussionmentioning

confidence: 99%

May Spasticity-Related Unpleasant Sensations Interfere with Daily Activities in People with Stroke and Traumatic Brain Injury? Secondary Analysis from the CORTOX Study

Facciorusso,

Spina,

Picelli

et al. 2024

JCM

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Background/Objectives: This study examined the impact of spasticity-related unpleasant sensations (pain, heaviness, stiffness) on various domains of the International Classification of Functioning, Disability, and Health (ICF) and psychosocial well-being in individuals affected by stroke or traumatic brain injury (TBI). The primary aim is to explore how these sensations affect daily activities, participation, and overall quality of life, guided by the comprehensive framework of the ICF. Methods: Utilizing a secondary analysis of data from a cohort undergoing Botulinum toxin type-A treatment for spasticity post-stroke or TBI, we developed and administered an ad-hoc questionnaire focusing on ICF domains such as body function, activities and participation, and psychosocial aspects such as mood, relationship, social life, motivation, and sleep quality. Spearman rho correlation was applied to assess the relationship between unpleasant sensations and functional as well as psychosocial outcomes among 151 participants. Results: This study identified significant correlations between the severity of unpleasant sensations and limitations in daily functioning, particularly in activities of daily living and mobility. Furthermore, an impactful association was identified between increased unpleasant sensations and deterioration in psychosocial well-being, notably in mood and sleep quality. Conclusions: These findings advocate for a person-centered approach in spasticity management, emphasizing the integration of sensory impairment strategies into rehabilitation to enhance functional outcomes and quality of life. Such an approach aims to improve functional outcomes and enhance the quality of life for individuals experiencing spasticity post-stroke or TBI. Future directions include targeted interventions to alleviate these sensations, support better rehabilitation results and improve patient experiences.

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Section: Discussionmentioning

confidence: 99%

May Spasticity-Related Unpleasant Sensations Interfere with Daily Activities in People with Stroke and Traumatic Brain Injury? Secondary Analysis from the CORTOX Study

Facciorusso,

Spina,

Picelli

et al. 2024

JCM

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“…Sensory Sensitivity Questionnaire . To date, there is no validated sensory sensitivity questionnaire that is adapted to stroke patients and that assesses all sensory modalities (for an overview of the diagnostic tools that are used to assess subjective sensory sensitivity after acquired brain injury, see Thielen et al, 2022). Therefore, in order to systematically assess poststroke subjective sensory sensitivity across different modalities (ie, multisensory, visual, auditory, tactile, olfactory, gustatory, environmental temperature, vestibular sensitivity, and pain), we developed a new, patient-friendly sensory sensitivity questionnaire.…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies have reported a subjective sensory hypersensitivity to sound in 44% of 341 individuals with mild traumatic brain injury (Shepherd et al, 2021) and a subjective sensory hypersensitivity to light in 51% of 86 individuals with mild to severe traumatic brain injury (Goodrich et al, 2014; for more details, see Thielen et al, 2022). Subjective sensory hypersensitivity after brain injury has been associated with longer recovery times and mental health difficulties (Callahan et al, 2018; O’Kane et al, 2014; Shepherd et al, 2021).…”

Section: Subjective Sensory Hypersensitivity and Acquired Brain Injurymentioning

confidence: 99%

“…When recruiting participants for lesion studies, de Haan and Karnath (2018) recommend including individuals with focal lesions such as those induced by stroke because the full extent of more diffuse damage (eg, diffuse axonal injury) cannot be detected using clinical brain scans. However, research on poststroke subjective sensory hypersensitivity is rare (Thielen et al, 2022). To our knowledge, the study by Chung and Song (2016) is the only study that has investigated the prevalence of poststroke subjective sensory hypersensitivity in a large stroke sample.…”

Section: Subjective Sensory Hypersensitivity and Lesion Neuroanatomymentioning

confidence: 99%

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The Neuroanatomy of Poststroke Subjective Sensory Hypersensitivity

Thielen

Tuts

Lafosse

et al. 2023

Cognitive and Behavioral Neurology

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Background: Although subjective sensory hypersensitivity is prevalent after stroke, it is rarely recognized by health care providers, and its neural mechanisms are largely unknown. Objective: To investigate the neuroanatomy of poststroke subjective sensory hypersensitivity as well as the sensory modalities in which subjective sensory hypersensitivity can occur by conducting both a systematic literature review and a multiple case study of patients with subjective sensory hypersensitivity. Method: For the systematic review, we searched three databases (Web of Science, PubMed, and Scopus) for empirical articles discussing the neuroanatomy of poststroke subjective sensory hypersensitivity in humans. We assessed the methodological quality of the included studies using the case reports critical appraisal tool and summarized the results using a qualitative synthesis. For the multiple case study, we administered a patient-friendly sensory sensitivity questionnaire to three individuals with a subacute right-hemispheric stroke and a matched control group and delineated brain lesions on a clinical brain scan. Results: Our systematic literature search resulted in four studies (describing eight stroke patients), all of which linked poststroke subjective sensory hypersensitivity to insular lesions. The results of our multiple case study indicated that all three stroke patients reported an atypically high sensitivity to different sensory modalities. These patients’ lesions overlapped with the right anterior insula, the claustrum, and the Rolandic operculum. Conclusion: Both our systematic literature review and our multiple case study provide preliminary evidence for a role of the insula in poststroke subjective sensory hypersensitivity and suggest that poststroke subjective sensory hypersensitivity can occur in different sensory modalities.

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“…Furthermore, recent evidence has pointed toward sensory (hyper)sensitivities being associated with acquired brain injury, leading to the suggestion that these may also be a feature in patients who have had encephalitis [21].…”

Section: Introductionmentioning

confidence: 99%

Mental health outcomes of encephalitis: An international web‐based study

Butler,

Abdat,

Zandi

et al. 2023

Euro J of Neurology

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Background and purposeAcute encephalitis is associated with psychiatric symptoms. Despite this, the extent of mental health problems following encephalitis has not been systematically reported.MethodsWe recruited adults who had been diagnosed with encephalitis of any aetiology to complete a web‐based questionnaire.ResultsIn total, 445 respondents from 31 countries (55.1% UK, 23.1% USA) responded. Infectious encephalitis constituted 65.4% of cases, autoimmune 29.7%. Mean age was 50.1 years, 65.8% were female, and median time since encephalitis diagnosis was 7 years. The most common self‐reported psychiatric symptoms were anxiety (75.2%), sleep problems (64.4%), mood problems (62.2%), and unexpected crying (35.2%). Self‐reported psychiatric diagnoses were common: anxiety (44.0%), depression (38.6%), panic disorder (15.7%), and posttraumatic stress disorder (PTSD; 21.3%). Severe mental illnesses such as psychosis (3.3%) and bipolar affective disorder (3.1%) were reported. Self‐reported diagnosis rates were broadly consistent with results from the Psychiatric Diagnostic Screening Questionnaire. Many respondents also reported they had symptoms of anxiety (37.5%), depression (28.1%), PTSD (26.8%), or panic disorder (20.9%) that had not been diagnosed. Rates of psychiatric symptoms did not differ between autoimmune and infectious encephalitis. In total, 37.5% respondents had thought about suicide, and 4.4% had attempted suicide, since their encephalitis diagnosis. More than half of respondents (53.5%) reported they had no, or substandard, access to appropriate mental health care. High rates of sensory hypersensitivities (>75%) suggest a previously unreported association.ConclusionsThis large international survey indicates that psychiatric symptoms following encephalitis are common and that mental health care provision may be inadequate. We highlight a need for proactive psychiatric input.

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Sensory sensitivity after acquired brain injury: A systematic review

Cited by 19 publications

References 142 publications

May Spasticity-Related Unpleasant Sensations Interfere with Daily Activities in People with Stroke and Traumatic Brain Injury? Secondary Analysis from the CORTOX Study

May Spasticity-Related Unpleasant Sensations Interfere with Daily Activities in People with Stroke and Traumatic Brain Injury? Secondary Analysis from the CORTOX Study

The Neuroanatomy of Poststroke Subjective Sensory Hypersensitivity

Mental health outcomes of encephalitis: An international web‐based study

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