Sentinel lymph node biopsy for early oral cancer – accuracy and considerations in patient selection

Vuity, Drazsen; McMahon, Jeremy; Hislop, Stuart; McCaul, James; Wales, Craig; Ansell, Mark; Thomson, Ewen; McGarvie, Jim; McLaughlin, Ian; Nicol, Alice; McLellan, Douglas

doi:10.1016/j.bjoms.2021.12.058

Cited by 9 publications

(1 citation statement)

References 13 publications

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“…The earliest lymph node(s) to drain a primary tumour are called sentinel lymph nodes [11]. It is still debatable whether sentinel lymph node biopsy (SLNB) or elective neck dissection (END) should be used to stage patients with early OSCC (T1 and T2 N0 disease) [12]. In the event that a lymphogenic tumour spreads, the sentinel lymph nodes (SLNs), which must be located and removed, are more likely to contain metastases.…”

Section: Sentinel Nodementioning

confidence: 99%

Head and neck lymphadenopathy in oral cancer

Tandon,

Sandhya,

Nath Singh

2023

Lymphatic System - From Human Anatomy to Clinical Practice

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Ranging from localised to generalised, infectious to neoplastic, autoimmune, or miscellaneous aetiology; lymphadenopathies have a wide array of clinical presentations. Assessment of the true pathobiology of lymphadenopathies is a challenging process specially cases with lymphadenopathy due to malignancies in the head and neck region. A multitude of masking signs and symptoms make it even more complicated. However, a correct diagnostic workflow facilitates easy evaluation of such lymphadenopathies. Although, the correct clinical examination may help to achieve correct diagnosis in some lymphadenopathy cases, some suspicious and unexplained lymphadenopathies warrant further investigations. This chapter clearly focuses on the clinical, diagnostic, and histopathologic spectrum of head and neck lymphadenopathies arising in oral cancer and stressing upon the pathways of lymphatic spread of malignancy along with a multitude of lymph node characteristics which play a key role in diagnosis.

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Section: Sentinel Nodementioning

confidence: 99%

Head and neck lymphadenopathy in oral cancer

Tandon,

Sandhya,

Nath Singh

2023

Lymphatic System - From Human Anatomy to Clinical Practice

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Evaluating Depth of Invasion as a Continuous Prognostic Factor in Oral Squamous Cell Carcinoma

Edri,

Dudkiewicz,

Yaniv

et al. 2024

Head & Neck

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BackgroundDepth of invasion (DOI) has a significant clinical impact on the staging system of oral squamous cell carcinoma (OSCC). We aimed to compare the prognostic impact of treating DOI as a continuous variable rather than a categorical one.MethodsA retrospective review of 277 OSCC patients surgically treated in a tertiary care center from 2000 to 2020, with a minimum 2‐year follow‐up. The analyses were performed using Cox and logistic regression.ResultsDOI as a continuous variable significantly predicted mortality in both univariate (p < 0.001) and multivariate (p < 0.001) analyses. It was also a significant predictor of locoregional recurrence (multivariate p = 0.039) and occult lymph node metastasis (univariate p = 0.005, multivariate p = 0.04). Categorical analysis failed to demonstrate the same significance.ConclusionsDOI as a continuous factor rather than a categorical one is significantly associated with mortality, locoregional recurrence, and occult lymph node metastasis. This innovative approach promotes personalized risk stratification and better decision‐making.

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