Sentinel Lymph Node Biopsy for Evaluation and Treatment of Patients With Merkel Cell Carcinoma

Gupta, Sheela; Wang, Linda C.; Peñas, Pablo F.; Gellenthin, Martina; Lee, Stephanie J.; Nghiem, Paul

doi:10.1001/archderm.142.6.685

Cited by 354 publications

(264 citation statements)

References 29 publications

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“…25 Approximately 33% (20 of 60) had a positive biopsy result and of these patients, only 1 had an isolated regional disease recurrence that occurred in the untreated contralateral neck. 27 A series of previously unpublished cases from the Dana-Farber Cancer Institute of 30 patients who underwent SLNB reported a 30% (9 of 30) lymph node positivity rate, 24 and there was 1 lymph node recurrence in this group. Maza et al reported on 11 patients with microscopic lymph node involvement by positive SLNB 28 ; 3 patients developed recurrence, however, none of them were lymph node recurrences.…”

Section: Discussionmentioning

confidence: 92%

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Radiation monotherapy as regional treatment for lymph node‐positive Merkel cell carcinoma

Fang

Lemos

Douglas

et al. 2010

Cancer

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145

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BACKGROUND:Merkel cell carcinoma (MCC) is an aggressive cutaneous malignancy with a high risk of lymph node involvement. To the authors' knowledge, few data have been published to date regarding the optimal regional therapy for lymph node‐positive patients. This cohort study was performed to analyze the outcomes of patients with lymph node‐positive MCC treated with lymph node irradiation as definitive therapy compared with completion lymphadenectomy (CLND).METHODS:Fifty patients with lymph node involvement of MCC at presentation and adequate follow‐up data were included in this analysis. Forty‐three of these patients were enrolled and followed prospectively. Twenty‐six patients presented with microscopic lymph node disease, and 24 patients presented with palpable lymph node involvement.RESULTS:Regional control for patients with microscopically involved lymph nodes was 100% regardless of treatment modality—definitive lymph node irradiation (n = 19) or CLND ± radiotherapy (n = 7) with median follow‐up of 18 months. Patients with clinically positive lymph nodes had 2‐year regional recurrence‐free survival rate of 78% and 73% in the definitive lymph node irradiation (n = 9) and CLND ± radiotherapy (n = 15) groups, respectively (P = .8) with a median follow‐up of 16 months.CONCLUSIONS:To the best of the authors' knowledge, the current study is the largest series published to date of radiation monotherapy as regional treatment for lymph node‐positive MCC. Lymph node irradiation alone to positive regional lymph nodes was found to confer an excellent regional control rate that was comparable to CLND for both microscopic and palpable lymph node disease. There was no difference noted with regard to overall survival. Given their similar efficacy, the choice between these lymph node therapies may be based on the clinical scenario and anticipated side effect profiles. Cancer 2010. © 2010 American Cancer Society.

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Section: Discussionmentioning

confidence: 92%

“…More recently, SLNB has become standard of care for MCC based on several reports and meta-analyses. [23][24][25] It is particularly appropriate in this disease given its predilection for occult lymph node involvement. SLNB is now recommended in the National Comprehensive Cancer Network guidelines.…”

Section: Discussionmentioning

confidence: 99%

Radiation monotherapy as regional treatment for lymph node‐positive Merkel cell carcinoma

Fang

Lemos

Douglas

et al. 2010

Cancer

Self Cite

145

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“…Gupta et al reported that the recurrence rate was three times higher in patients who were SLNB positive compared with an SLNBnegative group. 7 Interestingly, a statistically significant association was found between SLNB status and recurrence and survival in the largest singlecenter study. 8 Fields et al reported that the presence of lymphovascular invasion was a strong predictor of SLNB positivity.…”

Section: Discussionmentioning

confidence: 90%

Widespread Metastatic Involvement in a Patient with Merkel Cell Carcinoma on 68Ga-DOTATATE PET/CT: Case Report

Özkan¹,

Soydal²,

Alkan³

et al. 2017

Turkiye Klinikleri J Case Rep

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“…Thus far three systematic reviews have addressed lymphatic mapping in MCC [4,18]. Mehrany et al in the 2002 systematic review gathered all cases of sentinel node mapping in MCC by comprehensive search of the literature.…”

Section: Literature Review and Discussionmentioning

confidence: 99%

“…Sentinel node mapping is an important technique for regional lymph node staging in many solid tumors which has also been used for MCC [4].…”

Section: Introductionmentioning

confidence: 99%

Lymphatic mapping and sentinel node biopsy in a patient with upper limb Merkel Cell Carcinoma: a case report and brief review of literature

Kermani¹,

Rezaei²,

Zarifmahmoudi³

et al. 2016

Nucl. Med. Rev.

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Sentinel node mapping is an integral part of regional lymph node staging in many solid tumors and plays an important role in surgical oncology. This technique has been used with excellent results for non-melanoma skin cancers including Merkel Cell Carcinoma (MCC). In the current study, we reported our first MCC patient who underwent successful sentinel node mapping.We also reviewed the available literature regarding the prognostic significance of sentinel node mapping in cN0 MCC patients.

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Sentinel Lymph Node Biopsy for Evaluation and Treatment of Patients With Merkel Cell Carcinoma

Cited by 354 publications

References 29 publications

Radiation monotherapy as regional treatment for lymph node‐positive Merkel cell carcinoma

Radiation monotherapy as regional treatment for lymph node‐positive Merkel cell carcinoma

Widespread Metastatic Involvement in a Patient with Merkel Cell Carcinoma on 68Ga-DOTATATE PET/CT: Case Report

Lymphatic mapping and sentinel node biopsy in a patient with upper limb Merkel Cell Carcinoma: a case report and brief review of literature

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