Sentinel lymph node biopsy in squamous cell carcinomas of the lips and the oral cavity—A single center experience

Frerich, Bernhard; Förster, Marcus; Schiefke, Franziska; Wittekind, Christian; Hemprich, Alexander; Sabri, Osama

doi:10.1002/jso.20664

Cited by 25 publications

(17 citation statements)

References 48 publications

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“…We found 7 SN-positive patients among 45 clinically N0 patients; the upstage rate was 15.6% (7/45). In relevant literature dealing with head and neck mucosal squamous cell carcinoma, it ranges from 8.7 to 40% [6,[13][14][15]. The upstage rate of our study was not very diVerent from those reports.…”

Section: Discussioncontrasting

confidence: 69%

“…A falsenegative SN biopsy rate of 7.9% is not very diVerent compared with studies of head and neck cutaneous melanomas and mucosal squamous cell cancers. Those authors reported the false-negative rates of SN biopsy to be 0-10.5% [6,[14][15][16][17][18][19][20][21][22][23][24][25]. We found 7 SN-positive patients among 45 clinically N0 patients; the upstage rate was 15.6% (7/45).…”

Section: Discussionmentioning

confidence: 45%

“…Although a German study that describes an SN biopsy of oral/oropharyngeal cancer reported no false negatives in their cases [13], infrequent regional recurrences in SN-negative necks have been reported in the head and neck region [6,7,14,15]. In cutaneous melanoma, on the other hand, the value of the SN concept emerged earlier than in mucosal head and neck cancer.…”

Section: Discussionmentioning

confidence: 91%

“…Our policy of SN biopsy in oral cancer is a single-stage procedure; we execute multislice frozen section analysis intraoperatively, with postoperative reevaluation done by hematoxylin-eosin stain only. On the other hand, most patients in the abovementioned studies [6,[13][14][15]] underwent a two-stage procedure, i.e., stage one involved a primary resection and SN biopsy. After a pathologic workup on SN with a step serial section and immunohistochemistry, patients with positive SN underwent a neck dissection as a second surgery.…”

Section: Discussionmentioning

confidence: 99%

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Follow-up after intraoperative sentinel node biopsy of N0 neck oral cancer patients

Terada

Hasegawa

Yatabe

et al. 2010

Eur Arch Otorhinolaryngol

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The objective of the study was to evaluate the validity of sentinel node (SN) biopsy in early oral cancer patients focusing on the accuracy of intraoperative diagnoses of SN status, recurrences in follow-up and impact on patient survival. Previously untreated N0 oral cancer patients were candidates for the study. Using a radioisotope method, an intraoperative SN biopsy was performed. Patients with a positive frozen section of SN underwent immediate neck dissection as a single-stage procedure; they were followed in our outpatient clinic. Forty-five cT1-2N0 patients with squamous cell carcinoma were analyzed. There were seven patients with positive SN, five of whom were detected by intraoperative frozen section analysis. The sensitivity, specificity and accuracy of the intraoperative frozen section analysis of SN were 71.4, 100 and 95.6%, respectively. There were 13 recurrences in the course of all patients treated. Those with positive SN showed a tendency toward recurrence. Three patients with negative SN suffered from delayed ipsilateral neck recurrence. These were considered false negatives at a rate of 7.9%. The 5-year overall survival rate of all patients was 91.1%. SN-positive patient survival was significantly poorer than that of SN-negative patients. Positive SN had a negative impact on the survival. SN biopsy was shown to be a valuable method for determining the neck status of early oral cancer patients. The concordance rate of intraoperative multislice frozen section analysis of SN and patient neck status at the time of operation was 95.6%. SN-positive patients exhibited a tendency toward cancer recurrence. There were three cases of false negatives not conforming to the SN concept and their rate was 7.9%. Positive SN had a negative impact on patient survival.

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Section: Discussioncontrasting

confidence: 69%

Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Follow-up after intraoperative sentinel node biopsy of N0 neck oral cancer patients

Terada

Hasegawa

Yatabe

et al. 2010

Eur Arch Otorhinolaryngol

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“…The SNB procedure has shown acceptable sensitivity rates in pilot studies. [11][12][13] In the first multicenter trial for oral and oropharyngeal squamous cell carcinomas, sensitivity was 93% and, therefore, comparable with that of SND.…”

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confidence: 90%

Function, postoperative morbidity, and quality of life after cervical sentinel node biopsy and after selective neck dissection

et al. 2009

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The Oral Cavity and Lips

Scully

2004

Rook's Textbook of Dermatology

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Sentinel lymph node biopsy in squamous cell carcinomas of the lips and the oral cavity—A single center experience

Abstract: SLNB may contribute to more targeted lymph node dissection strategies. Further studies will have to ensure the safety of this procedure in comparison to selective neck dissection.

Cited by 25 publications

References 48 publications

Follow-up after intraoperative sentinel node biopsy of N0 neck oral cancer patients

Follow-up after intraoperative sentinel node biopsy of N0 neck oral cancer patients

Function, postoperative morbidity, and quality of life after cervical sentinel node biopsy and after selective neck dissection

The Oral Cavity and Lips

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