Sentinel Lymph Node Biopsy in Colon Cancer: an Institutional Experience

Saidha, Naresh Kumar; Mehta, Ritu; Malhotra, Munish; Singh, Aditya; Kumar, Deepankar; Sharma, Chandra P.

doi:10.1007/s13193-019-00957-y

Cited by 1 publication

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References 16 publications

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“…На сьогодні аналіз гістологічних змін у регіональних лімфовузлах при пухлинних процесах є обов'язковим компонентом патоморфологічного дослідження операційного матеріалу. Основною метою в таких випадках є виявлення або виключення ознак росту пухлини, тобто метастазів [1,2]. При цьому змінам структурних елементів самого лімфовузла часто не надають достатньої уваги, і описи обмежуються використанням зага-льних термінів «лімфоїдна гіперплазія», «лімфаденопатія», які не відображають рівень та переважаючий тип імунної відповіді, її індивідуальні особливості і тим більше інші можливі реакції.…”

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Castleman lymphadenopathy: case review

Gavrilyuk

Tomashova

Stolіar³

2021

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Background. While examining regional lymph nodes removed with the tumor, the pathomorphologist is often limited to the exclusion of metastases, omitting changes in lymphoid tissue. The aim of the work is to describe a rare variant of Castleman-like lymphadenopathy in the surgical material obtained during the removal of colon cancer with regional lymph nodes. Methods. Pathomorphological examination of removed lymph nodes using histological and immunohistochemical methods (CD23). Results. A 73-year-old patient underwent surgery for rectal cancer. Pathomorphological analysis diagnosed adenocarcinoma of high degree of differentiation (G1) and revealed Castleman-like changes in some of the enlarged regional mesenteric lymph nodes: signs of different stages of development of lymphoid follicles, including their hyperplasia, atresia and fragmentation with preservation of activated CD23+ follicular dendritic cells and reaction of microvasculature, including vascular proliferation in the interfollicular areas with uneven narrowing of the sinuses. The discussion analyzes the probable genesis of changes in lymphoid tissue, which may be a reflection of the early stage of Castleman's disease, complication of radiation therapy performed in the preoperative stage, or a consequence of impaired immune status due to tumor growth, in particular with antigenic overloading of draining lymphoid tissue, effects of cytokines produced by inflammatory infiltrate cells that accumulate directly near the tumor, and the formation of a state of genetic instability, which progresses under the influence of radiation. Conclusion. Despite the rarity of Castleman-like lymphadenopathy, in each case of examination of lymph nodes in the surgical material it is necessary to conduct a thorough analysis of lymphoid tissue, as this may be important both to assess the prognosis and to select adequate therapy.

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Section: вступunclassified

Castleman lymphadenopathy: case review

Gavrilyuk

Tomashova

Stolіar³

2021

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Sentinel Lymph Node Biopsy in Colon Cancer: an Institutional Experience

Cited by 1 publication

References 16 publications

Castleman lymphadenopathy: case review

Castleman lymphadenopathy: case review

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