Sentinel Lymph Node Biopsy in N0 Neck for Squamous Cell Carcinoma of Oral Cavity: a Prospective Study

Shivakumar, K.; Goel, Vipin; Manjunath, Suraj; Rajaram, Bapurapu; Ramesh, Rakesh; Ananthaneni, Anuradha; Hemanth, K.

doi:10.1007/s13193-016-0560-y

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…However, the need for a larger study group is highlighted [21]. Similar results were previously achieved by Shivakumar et al (97.7% identification rate) [23] and Rajaraman et al (90.6% identification rate) [9]. Initially, only sulfan blue was used for SLN mapping.…”

Section: Mapping With Methylene Blue Dye Alonesupporting

confidence: 67%

Methods for sentinel lymph node mapping in oral cancer: a literature review

Trepka-Sirek

Niedzielska

2022

Postępy Higieny I Medycyny Doświadczalnej

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Oral cancers, excluding non-melanoma skin cancer, are the most common cancers of the head and neck. Of these, 90% are squamous cell carcinomas (SCC). Surgery, which consists of dissection of the primary tumor and lymphadenectomy, is considered a radical method of treatment. There are several ranges of cervical lymphadenectomy: selective neck dissection (SND), modified radical neck dissection (MRND), and radical neck dissection (RND). The extension of surgery depends on the stage of clinical advancement, which can be determined by TNM classification, among other methods. The greatest controversy is related to SND in patients with cN0 (no evidence of regional lymph node metastasis), which is currently standard procedure. This approach is dictated by the possibility of hidden or subclinical metastases. The use of the sentinel lymph node (SLN) concept in patients with early stage of oral cancer and appropriate methods of its mapping may lead to a reduction in the extent of the lymphadenectomy procedure, thus reducing postoperative mortality and maintaining the patient’s function and quality of life, with correct oncological results. So far, available methods for SLN mapping are based on use of markers: methylene blue dye (MBD), metastable radioactive isotope Technetium (99mTc), or the fluorescent substance indocyanine green (ICG).

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Section: Mapping With Methylene Blue Dye Alonesupporting

confidence: 67%

Methods for sentinel lymph node mapping in oral cancer: a literature review

Trepka-Sirek

Niedzielska

2022

Postępy Higieny I Medycyny Doświadczalnej

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“…26 In another study of Shivakumar et al also found the identification rate of sentinel lymph node around 95%. 27 Alkureishi et al also showed the identification rate was 93% in their study. 28 The result of above studies supports the results of present study in both arms.…”

Section: Upper Alveolus and Hard Palatementioning

confidence: 72%

Assessment of sentinel lymph node detection by radioisotope scan and methylene blue alone in operable oral cavity cancer to assess its accuracy for metastasis

et al. 2021

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Background: Squamous cell carcinoma (SCC) is the most common malignancy affecting the oral cavity. It typically metastasizes into the regional cervical lymph nodes before spreading to distant organs.Methods: A prospective study on sentinel lymph node biopsy (SLNB) in early oral cancers using methylene blue dye and sentinel node localisation using pre-operative lymphoscintigraphy and intraoperative gamma probe in early oral cavity cancer.Results: Present study had a male to female ratio of 1.9:1, with (65.5%) male and (34.5%) female patients. Present study had a side distribution of disease more on left side with 138 patients (62.7%) and ratio of left to right was approximately 1.7:1. In present study most predominating gross morphological pattern of growth was ulcerative (35%) followed by ulcero-infilterative (25%). Buccal mucosa was the most common sub-site of origin of carcinoma in oral cavity, followed by tongue, with 83 (37.7%) and 64 (29.1%) patients. Identification rate of methylene blue dye was 91.7% (100 out of 109 patient). Identification rate of radionuclide tracer was 94.6% (105 out of 111 patient). In methylene blue dye group out of 103 metastatic sentinel lymph nodes, 9 metastatic sentinel lymph nodes were detected on IHC.Conclusions: With the above results it can be concluded the SLNB study is liable in detection of actual positive node and can avoid unnecessary neck dissections in patients with SCC with negative sentinel lymph node, as having very low risk of occult lymphatic metastases in the remaining lymphatic drainage.

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“…In addition, SND is not an innocuous procedure, as shoulder dysfunction may occur even when the accessory nerve is preserved, leading to a serious impact on quality of life [22]. Sentinel lymph node biopsy may be a good solution, with a false-negative rate of 3% [23]. However, its cost may be significantly higher [24] and it depends on the availability of the method, the experience of the center, and the learning curve of the surgeon [25].…”

Section: Discussionmentioning

confidence: 99%

Oral Cancer Treatment: Still an Indication for Elective Neck Dissection?

Koyama

Matos

Kulcsar

et al. 2018

ORL

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Introduction: Oral squamous cell carcinoma has a high incidence and, although elective neck dissection is recommended, the removed nodes frequently present without metastasis. This surgical approach causes disabilities and increases possible surgical complications. Objective: To evaluate the possibility of a watchful waiting approach in oral cancer. Methods: We compared 78 patients with clinical and pathological node metastases and their counterparts with pathological node metastases but without evident clinical neck disease. Therefore, we provided a theoretical comparison between the patients who had an elective neck dissection and those who waited until a clinically positive node was evident. Results: The prognostic factor rates were similar between the groups. Their regional recurrence and mortality rates had no statistical differences. Conclusion: A watchful waiting policy could be applied to selected oral cancer patients who can undergo a very close follow-up. This option would be more cost-effective and less harmful than elective neck dissection.

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Sentinel Lymph Node Biopsy in N0 Neck for Squamous Cell Carcinoma of Oral Cavity: a Prospective Study

Cited by 5 publications

References 10 publications

Methods for sentinel lymph node mapping in oral cancer: a literature review

Methods for sentinel lymph node mapping in oral cancer: a literature review

Assessment of sentinel lymph node detection by radioisotope scan and methylene blue alone in operable oral cavity cancer to assess its accuracy for metastasis

Oral Cancer Treatment: Still an Indication for Elective Neck Dissection?

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