Sentinel lymph node biopsy in head and neck rhabdomyosarcoma

Turpin, Brian; Pressey, Joseph G.; Nagarajan, Rajaram; Weiss, Brian; Trout, Andrew T.; Gelfand, Michael J.; Pater, Luke; Vatner, Ralph; Breneman, John C.; Dasgupta, Roshni

doi:10.1002/pbc.27532

Cited by 16 publications

(5 citation statements)

References 19 publications

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“…In light of limits for radiographic nodal staging for RMS and the presence of nodal disease in 9% of non-parameningeal and 18% of parameningeal cases, an additional consideration in the diagnostic evaluation is sentinel lymph node biopsy [ 27 ]. While more commonly utilized at other RMS disease sites, such as the extremities, use of sentinel node sampling was found to alter management in two of six patients with HNRMS in a single-institution case series including one patient with unexpected contralateral nodal disease [ 28 ]. This approach represents a less invasive strategy to accurately assess nodal involvement compared to neck dissection as used in squamous cell carcinoma in the adult population.…”

Section: Resultsmentioning

confidence: 99%

Radiation Therapy in the Treatment of Head and Neck Rhabdomyosarcoma

Frankart

Breneman

Pater

2021

Cancers

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The use of radiation therapy is an important part of multimodality treatment for rhabdomyosarcoma. The specific doses, treatment volumes, and techniques used in radiation therapy can vary dramatically based upon a number of factors including location, tumor size, and molecular characteristics, resulting in complex decisions in treatment planning. This article reviews the principles of evaluation and management for head and neck rhabdomyosarcoma including a summary of the historical studies upon which current management is based.

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Section: Resultsmentioning

confidence: 99%

Radiation Therapy in the Treatment of Head and Neck Rhabdomyosarcoma

Frankart

Breneman

Pater

2021

Cancers

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“…Sentinel lymph node (SLN) biopsy has been evaluated as a possible tool for accurate nodal staging in patients with head and neck rhabdomyosarcoma. In a small series of six patients, two of three patients with radiographically suspicious nodes by PET and/or MRI had a positive SLN, while one of three with negative imaging had a positive SLN 40 . Mapping of SLN yielded an unanticipated location of the SLN in two patients, with the nodes mapping in the contralateral neck.…”

Section: Consensus Guidelinesmentioning

confidence: 92%

Local control of parameningeal rhabdomyosarcoma: An expert consensus guideline from the International Soft Tissue Sarcoma Consortium (INSTRuCT)

Casey

Mandeville

Bradley

et al. 2022

Pediatric Blood & Cancer

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The International Soft Tissue Sarcoma Database Consortium (INSTRuCT) consists of a collaboration between the Children's Oncology Group (COG) Soft Tissue Sarcoma Committee, the European pediatric Soft Tissue Sarcoma Study Group (EpSSG), and the Cooperative Weichteilsarkom Studiengruppe (CWS). As part of the larger initiative of INSTRuCT to provide consensus expert opinions for clinical treatment of pediatric soft tissue sarcoma, we sought to provide updated, evidenced-based consensus guidelines for local treatment of parameningeal rhabdomyosarcoma using both existing literature as well as recommendations from the relevant cooperative group clinical trials. Overall, parameningeal rhabdomyosarcoma represents a distinctly challenging disease to treat, given its location near many critical structures in the head and neck, frequently advanced local presentation, and predilection for local failure. Definitive chemoradiation remains the standard treatment approach for parameningeal rhabdomyosarcoma, with surgery often limited to biopsy or salvage therapy for recurrent disease. In this consensus paper, we specifically discuss consensus guidelines and evidence for definitive local management with radiotherapy, with a focus on imaging for radiotherapy planning, dose and timing of radiation, approach for nodal irradiation, various radiation techniques, including proton therapy, and the limited role of surgical resection.

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“…In a small series of 6 patients, 2 of 3 patients with radiographically suspicious nodes by PET and/or MRI had a positive SLN, while 1 of 3 with negative imaging had a positive SLN. 40 Mapping of SLN yielded an unanticipated location of the SLN in 2 patients, with the nodes mapping in the contralateral neck. The use of SLN resulted in a change in the recommended treatment in 2 of the 6 patients.…”

Section: Gallego Et Al Reported On a Combined Analysis Of Patients Wi...mentioning

confidence: 99%

Local control of parameningeal rhabdomyosarcoma: An expert consensus guideline from the International Soft Tissue Sarcoma Consortium (INSTRuCT)

Casey

Mandeville

Bradley³

et al. 2022

Preprint

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The International Soft-Tissue Sarcoma Database Consortium (INSTRuCT) consists of a collaboration between the Children’s Oncology Group (COG) Soft Tissue Sarcoma Committee, the European pediatric Soft-Tissue Sarcoma Study Group (EpSSG), and the Cooperative Weichteilsarkom Studiengruppe (CWS). As part of the larger initiative of INSTRuCT to provide consensus expert opinions for clinical treatment of pediatric soft tissue sarcoma, we sought to provide updated, evidenced-based consensus guidelines for local treatment of parameningeal rhabdomyosarcoma using both existing literature as well as recommendations from the relevant cooperative group clinical trials. Overall, parameningeal rhabdomyosarcoma represents a distinctly challenging disease to treat given its location near many critical structures in the head and neck, frequently advanced local presentation, and predilection for local failure. Definitive chemoradiation remains the standard treatment approach for parameningeal rhabdomyosarcoma, with surgery often limited to biopsy or salvage therapy for recurrent disease. In this consensus paper, we specifically discuss consensus guidelines and evidence for definitive local management with radiotherapy, with a focus on imaging for radiotherapy planning, dose and timing of radiation, approach for nodal irradiation, various radiation techniques including proton therapy, and the limited role of surgical resection.

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Sentinel lymph node biopsy in head and neck rhabdomyosarcoma

Cited by 16 publications

References 19 publications

Radiation Therapy in the Treatment of Head and Neck Rhabdomyosarcoma

Radiation Therapy in the Treatment of Head and Neck Rhabdomyosarcoma

Local control of parameningeal rhabdomyosarcoma: An expert consensus guideline from the International Soft Tissue Sarcoma Consortium (INSTRuCT)

Local control of parameningeal rhabdomyosarcoma: An expert consensus guideline from the International Soft Tissue Sarcoma Consortium (INSTRuCT)

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