Sentinel Lymph Node Biopsy in N0 Squamous Cell Carcinoma of the Oral Cavity and Oropharynx

Hart, Robert D.; Nasser, Joseph G.; Trites, Jonathan; Taylor, Srj; Bullock, Martin; Barnes, David W.

doi:10.1001/archotol.131.1.34

Cited by 58 publications

(48 citation statements)

References 21 publications

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“…289 The sensitivity of SLN biopsy for squamous cell carcinoma of the oral cavity and oropharynx is reported to be between 89% and 100% and the false-negative rate 1% to 4%. [287][288][289] Preliminary studies have shown that SLN biopsy is a promising tool for use in patients with early oral and oropharyngeal squamous cell carcinoma. 289,290 These investigations also have shown, however, that multiple, bilateral, or skip SLN may occur.…”

Section: Sentinel Lymph Nodementioning

confidence: 99%

Cysts of the Neck, Unknown Primary Tumor, and Neck Dissection

Luna¹,

Pfaltz²

2009

Diagnostic Surgical Pathology of the Head and Neck

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Section: Sentinel Lymph Nodementioning

confidence: 99%

Cysts of the Neck, Unknown Primary Tumor, and Neck Dissection

Luna¹,

Pfaltz²

2009

Diagnostic Surgical Pathology of the Head and Neck

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“…The CT scan and MRI are important technical developments/advancements, helping in determining the presence, extent and local/ regional invasion of tumors 6-8. Investigators also explored the use of Gamma probes for determining occult metastasis in neck with limited success 9,10…”

Section: Introductionmentioning

confidence: 99%

Relationship of Oral Tumor Thickness with the rate of lymph node metastasis in Neck based on CT Scan

et al. 2017

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Objective:To determine the relationship of tumor thickness of oral lesions with metastasis in neck based on CT scan.Methods:A total of 58 oral squamous cell carcinoma patients having the median age of 46 (39-55) years. with either gender presented with malignant tumor of buccal mucosa and tongue were prospectively enrolled. A CT Scan with contrast was performed on all patients. Correlation of tumor thickness level with metastasis in neck was calculated using spearman’s rank correlation coefficient test.Results:Median age of the patients was 46 (39-55) years with preponderance of male gender, i.e. 48 (82.8%). Strong positive significant correlation was observed in between transverse dimension (TS) tumor size and stages of tumor (rho 0.673, p-value <0.001), Anterioposterior (AP) tumor size and stages of tumor (rho 0.675, p-value <0.001), and Craniocaudal (CC) tumor size and stages of tumor (rho 0.771, p-value <0.001).Conclusion:CT scan of neck with contrast can be used for predicting the positive presence of lymph node in neck with primary tumors having a size of more than 4 mm.

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“…PET/CT as a combined modality seems to provide even better results in nodal staging than does PET alone. • Sentinel lymph node detection by preoperative lymphoscintigraphy and intraoperative gamma probe localization has been extensively studied in melanoma and breast cancer, and a recent study has demonstrated very promising results in patients with N0 squamous cell carcinoma (SCC) of the oral cavity and oropharynx, with a negative predictive value of 100% [42].…”

Section: Metastatic Lymphadenopathymentioning

confidence: 99%

Imaging in head and neck cancer

Rumboldt

Gordon²,

Bonsall³

et al. 2006

Curr. Treat. Options in Oncol.

123

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The goals of imaging in head and neck cancer are to establish tumor extent and size, to assess nodal disease, to evaluate for perineural tumor spread, and to distinguish recurrent tumor from post-treatment changes. MRI is the preferred modality for assessment of nasopharyngeal, sinonasal, and parotid tumors, because of better contrast resolution, high frequency of perineural spread, and less prominent motion artifacts. MRI is the best modality to delineate the extent of intraorbital and intracranial extension of malignant tumors. Tumors of the oropharynx, larynx, and hypopharynx are frequently primarily imaged with CT, which is less affected by breathing and swallowing artifacts. MRI is also the initial study of choice for tumors confined to the oral tongue, and possibly also for other oral cavity locations because MRI is superior in detection of tumor spread into the bone marrow. There is no clear advantage of CT or MRI for evaluation of nodal disease. Positron emission tomography (PET) is very sensitive for metastatic lymph nodes that are at least 8 mm in size and is the technique of choice in dubious cases. Imaging-guided biopsies are performed whenever needed. For imaging of treated head and neck cancer, PET scans have been found to generally offer higher sensitivity than MRI or CT. Combined PET/CT may be the modality of choice because it almost completely eliminates the false-positive and false-negative PET findings. Patients with head and neck cancer who are referred to tertiary care centers commonly arrive with cross-sectional images obtained at other institutions. Reinterpretation of these studies by dedicated radiologists frequently leads to changes in findings, which alter treatment and affect prognosis.

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Sentinel Lymph Node Biopsy in N0 Squamous Cell Carcinoma of the Oral Cavity and Oropharynx

Cited by 58 publications

References 21 publications

Cysts of the Neck, Unknown Primary Tumor, and Neck Dissection

Cysts of the Neck, Unknown Primary Tumor, and Neck Dissection

Relationship of Oral Tumor Thickness with the rate of lymph node metastasis in Neck based on CT Scan

Imaging in head and neck cancer

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