Sentinel Lymph Node Detection in Thyroid Carcinoma Using
            <sup>68</sup>
            Ga-Tilmanocept PET/CT: A Proof-of-Concept Study Protocol

Vries, Lisa H. de; Lodewijk, Lutske; Keizer, Bart de; Rinkes, Inne H. Borel; Vriens, Menno R.

doi:10.2217/fon-2022-0165

Cited by 5 publications

(5 citation statements)

References 35 publications

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“…Besides, new tracers and techniques are currently under development and evaluation, such (68)Ga-tilmanocept PET/CT ( 21 ). These methods differ in the tracer employed, instruments necessary to identify the sentinel nodes, and logistics between the tracer injection and the surgical operation.…”

Section: The Methods Of Snm In Thyroid Cancermentioning

confidence: 99%

Sentinel node mapping in thyroid cancer: an overview

et al. 2023

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In this paper we describe the current status of sentinel node mapping (SNM) in thyroid tumors and its potential perspectives. SNM in thyroid cancer has been tested since the end of the twentieth century, mainly in papillary thyroid cancer (PTC) and in medullary thyroid cancer (MTC). In PTC, it has been employed to find occult lymph node metastases in the central compartment of the neck as an alternative or indication for prophylactic dissection, by several methods. All of them have proven effective in spotting sentinel nodes, but the results have been somewhat diminished by uncertainty about the clinical significance of occult metastases in differentiated thyroid cancer. SNM in MTC has also been used to find occult lymph node metastases in the lateral compartments of the neck, also with excellent results hindered by a similar doubt about the real clinical significance of MTC micrometastases. Well designed, adequately sized randomized controlled trials are lacking, so SNM in thyroid tumors remains an interesting yet experimental methodology. New technology is emerging that could facilitate such studies, which could add solid information about the clinical significance of occult neck metastases in thyroid cancer.

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Section: The Methods Of Snm In Thyroid Cancermentioning

confidence: 99%

Sentinel node mapping in thyroid cancer: an overview

et al. 2023

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“…Recently, new techniques have been proposed for detecting SLN in TC, such as 68Ga-tilmanocept PET/CT. In de Vries et al ( 89 ) proposed a study of SLN in TC according to a clinical protocol using 68Ga-tilmanocept PET-CT and ICG-99MTc-nanocolloid in ten patients with DTC and MTC. The patients will be given a sequential US-guided intra- or peritumoural injection of 68Ga-tilmanocept and ICG-99mTc-nanocolloid, followed 15–60 min later by 68Ga-tilmanocept PET/CT.…”

Section: Sln Procedures In Tcmentioning

confidence: 99%

“…At surgery, the SLN will be excised using the 68Ga-tilmanocept PET/CT images, the skin markings, a hand-held gamma probe and a fluorescence camera. According to the authors, the promising new imaging modality of 68Ga-tilmanocept PET-CT reduces the shine-through effect described in LS method, by better localizing the SLN close to the tumor ( 89 ).…”

Section: Sln Procedures In Tcmentioning

confidence: 99%

Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma

Boschin,

Bertazza,

Scaroni

et al. 2023

Front. Med.

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Sentinel lymph node (SLN) mapping is a standard, minimally-invasive diagnostic method in the surgical treatment of many solid tumors, as for example melanoma and breast cancer, for detecting the presence of regional nodal metastases. A negative SLN accurately indicates the absence of metastases in the other regional lymph nodes (LN), thus avoiding unnecessary lymph nodal dissection. Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma (TC) with cervical LN metastases at diagnosis in 20–90%, and nodal involvement correlates with local persistence/recurrence. The SLN in PTC is an intraoperative method for staging preoperative N0 patients and for detecting metastatic LNs “in and outside” the cervical LN central compartment; it represents an alternative method to prophylactic central neck node dissection. In this review we summarize different methods and results of the use of SLN in TC. The SLN identification techniques currently used include the selective vital-dye (VD) method, 99mTc-nanocolloid planar lymphoscintigraphy with intraoperative use of a hand-held gamma probe (LS), the combination LS + VD, and the combination LS and preoperative SPECT–CT (LS + SPECT/CT). The application of the SLN procedure in TC has been described in many studies, however, the techniques are heterogeneous, and the role of SLN in TC, with indications, results, advantages and limits, is still debated.

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“…Most previous studies that examined cervical lymph node metastasis of PTC mainly focused on the preoperative lymph node diagnosis technology, the scope of intraoperative lymph node exploration and dissection, and the re nement of postoperative pathological examination indicators, but not the speci c mechanism of early lymph node metastasis(de Vries, Lodewijk et al 2023). In order to further explore the molecular mechanism of lymph node metastasis, we performed proteomic measurements on tumor tissues and paired paracancerousous tissues from 5 clinically diagnosed PTC patients.…”

Section: Introductionmentioning

confidence: 99%

PAPSS2 inhibits proliferation and metastasis of papillary thyroid cancer cells by mediating ferroptosis and disulfidptosis through the AKT signaling pathway

Li,

Zhang,

Huang

et al. 2023

Preprint

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Papillary thyroid cancer (PTC) is the most common type of thyroid cancer(Derwich, Sykutera et al. 2023). Unfortunately, lymph node metastasis often occur in early stage of PTC, while the specific mechanism is still unclear(Wei, Wei et al. 2023). Previous in vivo study showed that PAPSS2 is a rate-limiting enzyme of the sulfation pathway. Interestingly, it has been known that the expression of PAPSS2 in PTC biopsy samples was significantly lower than that in paracancerous tissues. Bioinformatics analysis and preliminary study suggested that PAPSS2 might affect the metabolism of glycosaminoglycan sulfation and damage the extracellular matrix barrier by inhibiting the sulfation pathway, thus providing a suitable microenvironment for tumor metastasis. Our study showed that PAPSS2 could regulate ferroptosis and disulfidptosis of thyroid cancer cells through regulating the AKT signaling pathway and thereby induce cytoskeletal changes and lymph node metastasis. Our findings not only identified a novel therapeutic target but also shed light upon a better understanding of the pathogenesis of PTC.

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Sentinel Lymph Node Detection in Thyroid Carcinoma Using ⁶⁸ Ga-Tilmanocept PET/CT: A Proof-of-Concept Study Protocol

Cited by 5 publications

References 35 publications

Sentinel node mapping in thyroid cancer: an overview

Sentinel node mapping in thyroid cancer: an overview

Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma

PAPSS2 inhibits proliferation and metastasis of papillary thyroid cancer cells by mediating ferroptosis and disulfidptosis through the AKT signaling pathway

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Sentinel Lymph Node Detection in Thyroid Carcinoma Using 68 Ga-Tilmanocept PET/CT: A Proof-of-Concept Study Protocol

Cited by 5 publications

References 35 publications

Sentinel node mapping in thyroid cancer: an overview

Sentinel node mapping in thyroid cancer: an overview

Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma

PAPSS2 inhibits proliferation and metastasis of papillary thyroid cancer cells by mediating ferroptosis and disulfidptosis through the AKT signaling pathway

Contact Info

Product

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Sentinel Lymph Node Detection in Thyroid Carcinoma Using ⁶⁸ Ga-Tilmanocept PET/CT: A Proof-of-Concept Study Protocol