Sentinel lymph node identification (SLNI) in the management of conservative surgery in early cervical cancer: Is it acceptable?

Rob, Lukáš; Charvát, Martin; Robová, Helena; Strnad, Pavel; Pluta, Marek; Halaška, M; Hrehorčák, M.; Schlegerová, D; Táborská, Kateřina

doi:10.1016/j.ygyno.2005.07.068

Cited by 17 publications

(12 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Positive PLNs have been reported as a major predictive factor of a high risk of PI (3,6,13,(22)(23)(24). However, in our study, only one patient with PI had positive SLN (macrometastases) while five had PI with negative PLN.…”

Section: ------------------------------------------------------------contrasting

confidence: 65%

“…However, in our study, only one patient with PI had positive SLN (macrometastases) while five had PI with negative PLN. Rob et al reported that none of their negative-SLN patients with tumor size <3 cm had PI (24). In a subgroup of patients with tumor size <2 cm and stromal invasion <50%, Strnad et al found Table III.…”

Section: ------------------------------------------------------------mentioning

confidence: 99%

“…Finally, Panici et al reported PI in only 3% of cases with negativePLN versus 100% of cases in positive PLN (13). All these data (3,11,13,24) raise the issue of histological techniques to assess lymph node status both intra-operatively and on final histology. In the present study, none of the six patients with positive SLN were detected by intra-operative histology reflecting the low accuracy of imprint cytology.…”

Section: ------------------------------------------------------------mentioning

confidence: 99%

See 2 more Smart Citations

Clues pointing to simple hysterectomy to treat early-stage cervical cancer

Coutant

Cordier²,

Guillo³

et al. 2009

Oncol Rep

View full text Add to dashboard Cite

Abstract. Radical hysterectomy and pelvic lymphadenectomy is recommended for stage Ia2-Ib1 cervical cancer while parametrial involvement (PI) is rare. Our aim was to evaluate criteria to select women with low risk of PI that could benefit from simple hysterectomy. Factors associated with low risk of PI were analyzed in a series of 37 patients with stage Ia2-Ib1 cervical cancer undergoing radical hysterectomy and sentinel lymph node procedure from 2003 to 2008. PI was associated with tumor size (p<0.001) and lymphovascular space invasion (LVSI) (p=0.007). PI was found in 4.5% of patients with tumor size ≤2 cm versus 33% with tumor size >2 cm (p=0.04). The negative predictive value was 100% for absence of LVSI (95% CI: 0.83-1) and for combinations: tumor size ≤2 cm and SN negative (95% CI: 1-1), tumor size ≤2 cm and no LVSI (95% CI: 0.86-1), tumor size ≤2 cm and tumor grade 1-2 and no LVSI (95% CI: 0.82-1), and tumor size ≤2 cm and PLN negative and no LVSI (95% CI: 0.83-1). Among various combinations, a tumor size ≤2 cm and absence of LVSI appears the most relevant to predict parametrial status.

show abstract

Section: ------------------------------------------------------------contrasting

confidence: 65%

Section: ------------------------------------------------------------mentioning

confidence: 99%

Section: ------------------------------------------------------------mentioning

confidence: 99%

See 1 more Smart Citation

Clues pointing to simple hysterectomy to treat early-stage cervical cancer

Coutant

Cordier²,

Guillo³

et al. 2009

Oncol Rep

View full text Add to dashboard Cite

show abstract

“…In other words, there may be a metastasis present in a regional non-sentinel lymph node that is not detected with SN ultrastaging. Low false-negative rates of SN staging in cervical cancer patients have been reported from single institutional experiences, especially in tumors smaller than 2 cm [6][7][8][9]. In contrast, a German multicenter validation study observed an unsatisfactory sensitivity of SN biopsy (77.7%); however, ultrastaging of SN had not been performed in this group's study, so important data on micrometastasis were missing for the analysis [10].…”

mentioning

confidence: 77%

Bilateral ultrastaging of sentinel lymph node in cervical cancer: Lowering the false-negative rate and improving the detection of micrometastasis

Cibula

Abu‐Rustum

Dušek

et al. 2012

Gynecologic Oncology

126

View full text Add to dashboard Cite

“…The SLN procedure is now a widely accepted method of lymph node staging for selected cases of invasive breast cancer (3,4) and cutaneous melanoma (5). The concept is also being evaluated in numerous other types of cancer, including pelvic gynecologic (vulval, cervical, and endometrial) (6)(7)(8)(9), prostate (10), colon (11), gastric (12) and thyroid (13) cancer. In all cases, successful adaptation of the SLN procedure implies that the operator has a high identification rate and a low false-negative rate.…”

mentioning

confidence: 99%

Precise Localization of Sentinel Lymph Nodes and Estimation of Their Depth Using a Prototype Intraoperative Mini -Camera in Patients with Breast Cancer

Mathelin

Salvador²,

Huss³

et al. 2007

Journal of Nuclear Medicine

View full text Add to dashboard Cite

The aim of this study was to evaluate the ability of a prototype intraoperative mini g-camera, the CarolIReS, with a 50 · 50 mm field of view, to precisely localize sentinel lymph nodes (SLNs) and to determine their depth in a series of patients with infiltrative breast cancer requiring SLN excision. Methods: With the use of phantoms, the broadness of the signal of an acquired projection was shown to linearly depend on its distance from the collimator. A preclinical ex vivo study of 25 excised SLNs demonstrated that SLN size did not influence depth estimation. The minimum activity threshold for successful use of the proposed method was determined. After a preoperative radioisotope injection and lymphoscintigraphy, the SLN was localized in a series of 11 patients using both the mini g-camera and a g-probe. During surgery, a ruler was used to measure the depth of all SLNs before their excision. Results: Using the measured linear dependence of image broadness, we found that the expected SLN anatomic depth was compatible with its measured depth during surgery. Conclusion: This study showed that the mini g-camera efficiently estimated the location of SLNs in 3 dimensions.Key Words: breast cancer; lymphoscintigraphy; intraoperative gamma-camera; sentinel lymph node; CarolIReS Mostt ypes of lymphophile cancers require assessment of regional lymph nodes for staging the tumor, determining prognosis, and devising therapeutic strategies. Complete lymph node dissections are frequently associated with significant morbidity. Combining diagnostic advantages with decreased morbidity (1,2), the sentinel lymph node (SLN) procedure represents one of the most recent advances in surgical oncology. It consists of the identification and removal of SLNs, which are lymph nodes that receive lymphatic drainage directly from the primary tumor. The SLN procedure is now a widely accepted method of lymph node staging for selected cases of invasive breast cancer (3,4) and cutaneous melanoma (5). The concept is also being evaluated in numerous other types of cancer, including pelvic gynecologic (vulval, cervical, and endometrial) (6-9), prostate (10), colon (11), gastric (12) and thyroid (13) cancer. In all cases, successful adaptation of the SLN procedure implies that the operator has a high identification rate and a low false-negative rate. For SLN identification, in addition to the peroperative injection of a blue dye, a 99m Tc-radiomarked colloidal solution is generally injected the day before or the day of the surgery and 2 planar scintigraphic images are taken in a nuclear medicine department. In a recent metaanalysis (14) including 69 trials and 8,059 patients with low-risk breast cancer, the proportion of patients with successfully mapped SLNs ranged from 41% to 100%, with more than 50% of the studies reporting a rate under 90%. The false-negative rate ranged from 0% to 29%, averaging 7.3% overall. Significant inverse correlations were observed between the false-negative rate and the proportion of patients with successfully mapped SLN...

show abstract

Sentinel lymph node identification (SLNI) in the management of conservative surgery in early cervical cancer: Is it acceptable?

Cited by 17 publications

References 1 publication

Clues pointing to simple hysterectomy to treat early-stage cervical cancer

Clues pointing to simple hysterectomy to treat early-stage cervical cancer

Bilateral ultrastaging of sentinel lymph node in cervical cancer: Lowering the false-negative rate and improving the detection of micrometastasis

Precise Localization of Sentinel Lymph Nodes and Estimation of Their Depth Using a Prototype Intraoperative Mini -Camera in Patients with Breast Cancer

Contact Info

Product

Resources

About