2010
DOI: 10.1007/s10151-010-0582-3
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Sentinel lymph node in patients with rectal cancer invading the anal canal

Abstract: The standardized procedure was highly effective in sampling inguinal sentinel nodes in very low rectal cancers, allowing the detection of subclinical metastatic disease. Although this technique can be potentially useful for a subgroup of patients with isolated inguinal metastases, it cannot be routinely recommended for patients with rectal tumors invading the anal canal at this moment.

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Cited by 12 publications
(15 citation statements)
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“…However, all patients with INMs also had metastatic perirectal nodes (ypN+) and 75% of these patients developed systemic metastasis at additional sites within 6 months. One patient underwent bilateral groin dissection with removal of additional unsuspected INMs . It seems, therefore, that unsuspected INMs are probably underestimated by clinical assessment alone and that, when present, outcomes are significantly worse.…”
Section: Discussionmentioning
confidence: 98%
“…However, all patients with INMs also had metastatic perirectal nodes (ypN+) and 75% of these patients developed systemic metastasis at additional sites within 6 months. One patient underwent bilateral groin dissection with removal of additional unsuspected INMs . It seems, therefore, that unsuspected INMs are probably underestimated by clinical assessment alone and that, when present, outcomes are significantly worse.…”
Section: Discussionmentioning
confidence: 98%
“…The use of sentinel LN may help identify tumors with inguinal LN metastases and change the surgical procedure. 20 However, in spite of the results described herein, several issues may hamper clinical application of liposomal ICG. NIR imaging penetrance is limited in its depth to 5 to 10 mm.…”
Section: Discussionmentioning
confidence: 75%
“…Furthermore, identification of the disease characteristics linked to an increased risk of developing IGN recurrence in addition to ACI will assist in decisions regarding elective IGN irradiation in the minority of patients who will benefit from this treatment despite the potential for complications. Research in rectal cancer has included the sentinel node procedure [ 21 ], serial acquisition of 18 F-deoxyfluoroglucose positron emission tomography-CT [ 22 ], and the study of histological tumor features at the distal front invading the dentate line [ 23 ].…”
Section: Discussionmentioning
confidence: 99%