Sentinel lymph node metastasis in primary cutaneous basosquamous carcinoma. A cross‐sectional study

Abstract

Cutaneous BSC is associated with early nodal metastatic potential. Tumor size >2 cm, lymphatic and perineural invasion are significant determinants for SLN micrometastasis. In the absence of palpable lymphadenopathy, wide resection and SLNB with long-term follow-up are highly recommended in these patients.

Basosquamous Carcinoma: A Commentary

“…However, there is open controversy regarding whether SLNB should be offered in BSCs for the early diagnosis of occult nodal metastasis, staging and treatment of subclinical node disease [ 17 , 27 ]. Kakagia et al, in a prospective study with 142 patients with BSC, concluded that tumor size >2 cm in addition to lymphatic and perineural invasion are significant determinants of SLN micrometastasis [ 46 ]. In the absence of palpable lymphadenopathy, wide resection and SLNB with long-term follow up is highly recommended in these patients [ 46 ].…”

“…Kakagia et al, in a prospective study with 142 patients with BSC, concluded that tumor size >2 cm in addition to lymphatic and perineural invasion are significant determinants of SLN micrometastasis [ 46 ]. In the absence of palpable lymphadenopathy, wide resection and SLNB with long-term follow up is highly recommended in these patients [ 46 ]. However, a possible “preventive benefit” of early SLNB for the nodal spread and distant metastasis needs further prospective controlled studies, with a longer follow-up period, in order to be confirmed [ 46 ].…”

Inguinal Metastasis from Basal Cell Carcinoma of the Vulva

“…However, cases of successful sentinel lymph node sampling to detect nodal metastasis in BCC, particularly basosquamous cell carcinoma, have been published [10]. Further research is required to determine which patients would benefit from this approach, in particular those with lesions measuring >20 mm and/or perineural/lymphatic invasion [11].…”

Cells to Surgery Quiz: December 2019

“…Perineural growth, also referred to as perineural invasion, is a classic indicator of aggressive disease for any cutaneous malignancy (Buchanan et al, 2014). Along with a tumor size >2 cm and lymphatic invasion, perineural involvement is a significant determinant for sentinel lymph node micrometastasis (Kakagia et al, 2018).…”

“…Another study evaluated 1,000 consecutive Mohs cases and found that two of 228 cases of patients with SCC had pulmonary metastases (0.87%), compared with two of 27 patients with BSC (7.4%) (Bowman et al, 2003). Similarly, a more recent study revealed that 11 of 142 (7.7%) patients with BSC had sentinel lymph node micrometastasis (Kakagia et al, 2018). Furthermore, whether BSC arises de novo or originates from a pre-existing BCC continues to be under debate.…”