Sentinel Lymph Node Methods in Breast Cancer

Giammarile, Francesco; Vidal-Sicart, Sergi; Páez, Diana; Pellet, Olivier; Estrada-Lobato, Enrique; Lette, Miriam Mikhail; Morozova, Olga; Camila, Navarro Marulanda Maria; Ivonne, Rodríguez Sanchez Diana; Delgado-Bolton, Roberto; Olmos, Renato A. Valdés; Mariani, Giuliano

doi:10.1053/j.semnuclmed.2022.01.006

Cited by 43 publications

(25 citation statements)

References 77 publications

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“…Therefore, detection, evaluation, and selective removal of SLN may be a beneficial oncologic procedure to decrease surgical morbidity related to extensive nodal dissection in patients with negative lymph nodes [ 105 ]. The SLN concept proved to be safe and feasible in other neoplasms, such as breast [ 106 , 107 , 108 ], melanoma [ 109 , 110 , 111 ], and some gynecological cancers, including vulvar cancer [ 101 , 103 , 112 ]. Studies performed through SLN biopsy in patients with early-stage vulvar cancer demonstrated that SLN mapping is safe, presents high rates of cancer detection, and is highly effective when performed by experienced surgeons [ 13 , 88 , 101 , 113 , 114 ].…”

Section: Treatmentmentioning

confidence: 99%

Management of Early-Stage Vulvar Cancer

Pedrão

Guimarães

Possati-Resende

et al. 2022

Cancers

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Vulvar cancer is a rare gynecological malignancy since it represents 4% of all cancers of the female genital tract. The most common histological type is squamous cell carcinoma (90%). This type can be classified into two clinicopathological subtypes according to the etiology. The first subtype is associated with persistent human papillomavirus infection and is usually diagnosed in younger women. The second subtype is associated with lichen sclerosus condition, and in most cases is diagnosed in postmenopausal women. Currently, an increase in first subtype cases has been observed, which raised the concern about associated mortality and treatment morbidity among young women. Vulvar cancer treatment depends on histopathology grade and staging, but surgery with or without radiotherapy as adjuvant treatment is considered the gold standard. In recent decades, sentinel lymph node biopsy has been incorporated as part of the treatment. Therefore, we sought to review and discuss the advances documented in the literature about vulvar cancer focusing on the treatment of early-stage disease. Relevant articles, such as the GROINS-V studies and the GOG protocols, are presented in this review. Additionally, we discuss key points such as the evolution of treatment from invasive surgery with high morbidity, to more conservative approaches without compromising oncologic safety; the role of sentinel lymph node mapping in the initial staging, since it reduces the complications caused by inguinofemoral lymphadenectomy; the recurrences rates, since local recurrence is common and curable, however, groin-associated, or distant recurrences have a poor prognosis; and, finally, the long-term follow-up that is essential for all patients.

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Section: Treatmentmentioning

confidence: 99%

Management of Early-Stage Vulvar Cancer

Pedrão

Guimarães

Possati-Resende

et al. 2022

Cancers

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“…Kai krūties vėžys ankstyvas, vaizdiniai tyrimai nėra pakankamai jautrūs naviko metastazėms limfmazgiuose nustatyti, todėl sarginiai limfmazgiai turi būti šalinami atliekant operaciją ir siunčiami histologiniam tyrimui atlikti. Tai patikimas metodas nustatyti krūties vėžio išplitimą moterims, kurių auglys mažesnis negu 2 cm ir nėra klinikinių išplitusios ligos požymių [7].…”

Section: įVadasunclassified

“…• Metileno mėlio injekcijos vietoje gali išlikti sukietėjimas, pastebimas odos spalvos pokytis. [7,19] Į poodį Subareoliariai Periareoliariai…”

Section: Injekcijos Būdai Privalumai Trūkumai Publikacijosunclassified

Detection of Sentinel Lymph Nodes During Breast Cancer Surgery: A Literature Overview

Šepetys

Gudavičienė

Jakutis

2023

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Introduction. Detecting metastases is an important part of successful breast cancer treatment. Usually, the tumor tissue first spreads to the sentinel lymph nodes. Removal of the latter during surgery and histological examination allows to assess the patient’s disease stage, prognosis and treatment. The literature provides more than one approach or a combination of them, allowing us to accurately identify the breast’s sentinel lymph nodes and avoid removing all axillary lymph nodes. Purpose. To review the methods of intraoperative detection of breast sentinel lymph nodes presented in the literature. Research material and methods. Publications were searched using the specialized information search system Google Scholar. Keywords used in the search: breast sentinel lymph nodes, intraoperative detection. After evaluating the exclusion criteria, the review was based on 25 scientific publications. Results. 4 individual measures and 2 combinations of them can be used to detect sentinel breast lymph nodes during surgery. The materials used can be injected in 6 different ways. Conclusions. The combination of technetium-99m radiocolloid and methylene blue can be evaluated as the best method for intraoperative detection of sentinel lymph nodes in breast cancer patients. On the other hand, due to radiation and operating costs, more attention is being paid to the use of indocyanine green, superparamagnetic iron oxide, methylene blue dye, and the detection of metastases without surgery. Superficial methods of injecting the substance should be combined with deep ones due to the possibility of detecting extra-axillary sentinel lymph nodes of the breast. Ultimately, all decisions must be made on a case-by-case basis.

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“…BC is the most frequently diagnosed cancer in women worldwide ( 91 ). METTL3 facilitated m6A modification of the 3′ UTR of B-cell/lymphoma 2 (BCL-2) mRNA, which in turn promoted cell proliferation, migration and suppressed apoptosis through upregulation of BCL-2 expression ( 92 ).…”

Section: M6a Modification and Solid Tumorsmentioning

confidence: 99%

The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma

et al. 2022

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N6-methyladenosine (m6A) RNA methylation is an epigenetic modification that has emerged in the last few years and has received increasing attention as the most abundant internal RNA modification in eukaryotic cells. m6A modifications affect multiple aspects of RNA metabolism, and m6A methylation has been shown to play a critical role in the progression of multiple cancers through a variety of mechanisms. This review summarizes the mechanisms by which m6A RNA methylation induced peripheral cancer cell progression and its potential role in the infiltration of immune cell of the glioblastoma microenvironment and novel immunotherapy. Assessing the pattern of m6A modification in glioblastoma will contribute to improving our understanding of microenvironmental infiltration and novel immunotherapies, and help in developing immunotherapeutic strategies.

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Sentinel Lymph Node Methods in Breast Cancer

Cited by 43 publications

References 77 publications

Management of Early-Stage Vulvar Cancer

Management of Early-Stage Vulvar Cancer

Detection of Sentinel Lymph Nodes During Breast Cancer Surgery: A Literature Overview

The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma

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