Sentinel lymph node staging of cutaneous melanoma: predictors and outcomes

Ellis, Michelle C.; Weerasinghe, Roshanthi; Corless, Christopher L.; Vetto, John T.

doi:10.1016/j.amjsurg.2010.01.019

Cited by 44 publications

(30 citation statements)

References 18 publications

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“…Our data confirm previous studies [1,2] and support the clinical usefulness of SLNB as a reliable and accurate staging method in patients with cutaneous melanoma. However, the interest of complementary lymph node dissection in patients with positive SLN remains to be demonstrated.…”

Section: Discussionsupporting

confidence: 91%

P023. Sentinel lymph node biopsy for melanoma

Biver-Dalle

Puzenat

Algros³

et al. 2011

Melanoma Research

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with Dacarbazine 800 mg/m 2 . Subsequently she was randomized into a phase 3 clinical trial with the experimental compound Tasisulam receiving 2 cycles. Radiologic assessment showed partial response in all measurable lesions. After global suspension of the trial patients were no longer eligible to receive further treatment. Two weeks after the last CT-scan the patient developed macrohematuria and increase of pain in the lower abdomen. Cystoscopy showed a large tumorous structure located on the left side of the urinary bladder. Extensive immunhistochemical work-up of the resected tumor tissue was positive for S100, Vimentin and Ncam (CD56), but negative for Melan-A and HMB-45. Clinically the amelanotic tumor showed endophytic growth into the lumen of urinary bladder, histologically it had a P024. Electro-immunotherapy with BCG of superficial in-transit melanoma metastases

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Section: Discussionsupporting

confidence: 91%

P023. Sentinel lymph node biopsy for melanoma

Biver-Dalle

Puzenat

Algros³

et al. 2011

Melanoma Research

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“…Non-severe postoperative complications after SLNB were observed in 28% of patients.Conclusion:Our data confirm previous studies[1,2] and support the clinical usefulness of SLNB as a reliable and accurate staging method in patients with cutaneous melanoma. Head and neck melanoma were excluded.…”

supporting

confidence: 90%

P022. An exceedingly rare case of primary rhabdoid melanoma of the urinary bladder

Schindler¹,

Harmankaya²,

Haitel

et al. 2011

Melanoma Research

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“…Factors that have been investigated include patient age, 1–24 sex, 1–21,23,24 site of primary tumor, 1–3,6,8–11,13–21,23–27 Breslow thickness, 1–27 Clark level, 1–4,6,8,9,12,13,15–18,20,23,24,27 ulceration, 1–8,10–20,22–24,26,27 vertical growth phase, 1,8,14,17 tumor-infiltrating lymphocytes (TIL), 1,6,10,15,17 tumor mitotic rate (TMR), 1,6,7,10,11,14–17,20,25 histologic type, 1,4,7,8,11,17,19,20,22 lymphovascular invasion (LVI), 1,7,8,10,11,14,22,23 regression, 1,6–8,10,11,14,22,24,28–30 number of draining basins, 1,4,7,8,11,12,16,17,22 number of SLNs collected, 7,11,17 T classification, …”

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confidence: 99%

Factors Predictive of the Status of Sentinel Lymph Nodes in Melanoma Patients from a Large Multicenter Database

et al. 2011

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Background Numerous predictive factors for cutaneous melanoma metastases to sentinel lymph nodes have been identified; however, few have been found to be reproducibly significant. This study investigated the significance of factors for predicting regional nodal disease in cutaneous melanoma using a large multicenter database. Methods Seventeen institutions submitted retrospective and prospective data on 3463 patients undergoing sentinel lymph node (SLN) biopsy for primary melanoma. Multiple demographic and tumor factors were analyzed for correlation with a positive SLN. Univariate and multivariate statistical analyses were performed. Results Of 3445 analyzable patients, 561 (16.3%) had a positive SLN biopsy. In multivariate analysis of 1526 patients with complete records for 10 variables, increasing Breslow thickness, lymphovascular invasion, ulceration, younger age, the absence of regression, and tumor location on the trunk were statistically significant predictors of a positive SLN. Conclusions These results confirm the predictive significance of the well-established variables of Breslow thickness, ulceration, age, and location, as well as consistently reported but less well-established variables such as lymphovascular invasion. In addition, the presence of regression was associated with a lower likelihood of a positive SLN. Consideration of multiple tumor parameters should influence the decision for SLN biopsy and the estimation of nodal metastatic disease risk.

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Sentinel lymph node staging of cutaneous melanoma: predictors and outcomes

Cited by 44 publications

References 18 publications

P023. Sentinel lymph node biopsy for melanoma

P023. Sentinel lymph node biopsy for melanoma

P022. An exceedingly rare case of primary rhabdoid melanoma of the urinary bladder

Factors Predictive of the Status of Sentinel Lymph Nodes in Melanoma Patients from a Large Multicenter Database

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