Sentinel node biopsy for lymph nodal staging of uterine cervix cancer: A systematic review and meta-analysis of the pertinent literature

Kadkhodayan, Sima; Hasanzadeh, Malihe; Treglia, Giorgio; Azad, Afrooz; Yousefi, Zohreh; Zarifmahmoudi, Leili; Sadeghi, Ramin

doi:10.1016/j.ejso.2014.09.010

Cited by 123 publications

(110 citation statements)

References 96 publications

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“…In cervical cancer, a recent review showed a lower FN rate of SN when only smaller tumors were included. 62 The observation that tumor load is associated with FN rate is also compatible with the notion that the injection site of the SN tracer is associated with anatomical location of the SN in PCa patients. 13 For accuracy of the SN procedure, intratumoral tracer injection has been suggested to be superior compared with random injection of tracer in the prostate.…”

Section: Causes Of Fn Sn Proceduressupporting

confidence: 75%

Advances in sentinel node dissection in prostate cancer from a technical perspective

et al. 2015

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Abbreviations & Acronyms ePLND = extended pelvic lymph node dissection FN = false negative ICG = indocyanine green LN = lymph node MRI = magnetic resonance imaging NIR = near-infrared NR = not reported PCa = prostate cancer PET = positron emission tomography PLND = pelvic lymph node dissection SN = sentinel node SPECT-CT = single-photon emission computed tomography combined with computed tomography TRUS = transrectal ultrasound Abstract: The most important feature of sentinel node biopsy for prostate cancer procedure is that staging can be improved. Sentinel nodes might be found outside the extended pelvic lymph node dissection template what renders the sentinel node additive of extended pelvic lymph node dissection. At the same time, staging within the template can be further refined. We reviewed the literature regarding the sentinel node biopsy procedure for prostate cancer. PubMed and Embase were searched for all Englishlanguage publications from January 1999 to September 2014 by using the keywords as "prostate cancer" and "sentinel lymph node" plus "biopsy" "dissection" and/or "procedure." The present review discusses step-by-step sentinel node biopsy for prostate cancer. Topics of discussion are: (i) preoperative sentinel node mapping (tracers and imaging); (ii) intraoperative sentinel node identification (surgical procedure and outcome); and (iii) novelties to improve sentinel node identification (pre-and intraoperative approaches). Conventional sentinel node mapping is carried out after the injection of a 99m Tc-based tracer and subsequent preoperative imaging; for example, lymphoscintigraphy and singlephoton emission computed tomography/computed tomography. This approach allowed the detection of sentinel nodes outside the extended lymph node dissection template in 3.6-36% of men with intermediate-and high-risk prostate cancer. Hereby, an overall false negative rate of sentinel nodes was reported between 0% and 24.4%. To further refine the intraoperative sampling procedure, novel imaging methods such as fluorescence imaging have been introduced. Prospective randomized comparison studies are required to confirm the added benefit of sentinel template directed nodal dissection. A proper and obtainable end-point of such a study could be the number of removed positive nodes for carrying out nodal dissection with or without sentinel template directed dissection. Similarly, the clinical impact of novel imaging technologies requires further investigation.

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Section: Causes Of Fn Sn Proceduressupporting

confidence: 75%

Advances in sentinel node dissection in prostate cancer from a technical perspective

et al. 2015

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“…As a result, several authors have suggested the use of sentinel lymph node (SLN) mapping to reduce the rate of unnecessary LN dissection. A recently published metaanalysis reported the accuracy of SLN in this setting to be around 89% [12]. The large prospective SENTICOL trial has evaluated the use of pre-operative lymphoscintigraphy and intraoperative SLN mapping in women with stage IA1 to IB1 CC [13].…”

Section: Fertility-sparing Surgery In CCmentioning

confidence: 99%

Conservative treatment in cervical cancer

Bergamini

Morice

2016

CBN

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Cervical cancer (CC) is increasingly being diagnosed in women of reproductive age, and fertility-sparing treatment has become an essential part of the therapeutic strategy for early stage CC (FIGO stage IA1-IB1). Conization is currently considered a safe and feasible treatment for stage IA1 CC without lymphovascular space invasion (LVSI). After the first report proposing vaginal radical trachelectomy (VRT) for the treatment of stage IB1 cervical tumors, several studies have evaluated vaginal, abdominal, and minimally-invasive approaches. Recent decades have been characterized by increased conservative treatment of more advanced tumors; in addition, several series assessing the oncological and obstetric outcomes of less radical surgery have been published. This review provides and overview of current evidence-based knowledge about the conservative management of CC, focusing on new perspectives and controversial issues.

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“…34 Other studies have shown similar results. [35][36][37] However, the following criteria must be met: the technique is indicated for tumors in stages IA2, IB1 and IIA1 (tumor up to 4 cm), except for cases in which there is reduced sensibility using the method, such as in tumors sized more than 2 cm; absence of lymph node involvement (on imaging and intraoperative); bilateral identification of the sentinel lymph node (at least one node in each hemi-pelvis). The accuracy of the method is improved by lymph nodal "ultra-staging" (serial sections of the sentinel lymph node).…”

Section: Fertility Preservationmentioning

confidence: 99%

“…The accuracy of the method is improved by lymph nodal "ultra-staging" (serial sections of the sentinel lymph node). 36,37 Nevertheless, it cannot be performed during surgery, and, if the nodes are positive, a second operation is needed. The SENTICOL II trial is cur-tion included in the study, 75% had received prior treatment with cisplatin for recurrent disease.…”

Section: Fertility Preservationmentioning

confidence: 99%

Cervical cancer: what's new?

Sadalla

Andrade

Genta³

et al. 2015

Rev. Assoc. Med. Bras.

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Financial support: none Cervical cancer is the most common gynecological cancer in Brazil. Among women, it is the second most frequent, second only to breast cancer. It is the fourth leading cause of cancer death in the country, with estimated 15,590 new cases (2014) and 5,430 deaths (2013). In order to update information to improve outcomes, reduce morbidity and optimize the treatment of this cancer, this article will address the advancement of knowledge on cervical cancer. The topics covered include the role of surgery in different stages, treatment of locally advanced carcinomas, fertility preservation, the role of the sentinel lymph node technique, indications and techniques of radiotherapy and chemotherapy, and some special situations.

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Sentinel node biopsy for lymph nodal staging of uterine cervix cancer: A systematic review and meta-analysis of the pertinent literature

Cited by 123 publications

References 96 publications

Advances in sentinel node dissection in prostate cancer from a technical perspective

Advances in sentinel node dissection in prostate cancer from a technical perspective

Conservative treatment in cervical cancer

Cervical cancer: what's new?

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