Sentinel node biopsy in patients with cutaneous melanoma of the head and neck: Recurrence and survival study

Gomez-Rivera, Fernando; Santillan, Alfredo A.; McMurphey, Andrea Barber; Paraskevopoulos, G.; Roberts, Dianna B.; Prieto, Víctor G.; Myers, Jeffrey N.

doi:10.1002/hed.20875

Cited by 58 publications

(71 citation statements)

References 35 publications

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“…However, overlooking micrometastasis in SN when dealing with intraoperative frozen sections and/or permanent sections is perhaps the simplest and most likely explanation for them. Some authors have reported that a pathologic reevaluation revealed a metastasis overlooked in a negative SN specimen [23]; others reported that a reexamination uncovered no additional metastasis [24,25]. In our series, we reevaluated three false-negative patients' residual blocks by preparing sections of hematoxylin-eosin stain and immunohistochemistry using a pan-cytokeratin (AE1/AE3) every 75 m. The attending pathologist found no metastasis in these specimens.…”

Section: Discussionmentioning

confidence: 93%

“…There are abundant studies of SN biopsy in the trunk, extremities and head and neck. In these studies, the recurrence rate in the prior SN-negative lymphatic basin ranged from 0 to 10.5%; this rate occurred much more frequently in the head and neck than in other regions [16][17][18][19][20][21][22][23][24][25]. Chao et al [17] indicated that the higher false-negative rate of SN biopsy in head and neck cutaneous melanomas was statistically signiWcant.…”

Section: Discussionmentioning

confidence: 93%

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Follow-up after intraoperative sentinel node biopsy of N0 neck oral cancer patients

Terada

Hasegawa

Yatabe

et al. 2010

Eur Arch Otorhinolaryngol

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The objective of the study was to evaluate the validity of sentinel node (SN) biopsy in early oral cancer patients focusing on the accuracy of intraoperative diagnoses of SN status, recurrences in follow-up and impact on patient survival. Previously untreated N0 oral cancer patients were candidates for the study. Using a radioisotope method, an intraoperative SN biopsy was performed. Patients with a positive frozen section of SN underwent immediate neck dissection as a single-stage procedure; they were followed in our outpatient clinic. Forty-five cT1-2N0 patients with squamous cell carcinoma were analyzed. There were seven patients with positive SN, five of whom were detected by intraoperative frozen section analysis. The sensitivity, specificity and accuracy of the intraoperative frozen section analysis of SN were 71.4, 100 and 95.6%, respectively. There were 13 recurrences in the course of all patients treated. Those with positive SN showed a tendency toward recurrence. Three patients with negative SN suffered from delayed ipsilateral neck recurrence. These were considered false negatives at a rate of 7.9%. The 5-year overall survival rate of all patients was 91.1%. SN-positive patient survival was significantly poorer than that of SN-negative patients. Positive SN had a negative impact on the survival. SN biopsy was shown to be a valuable method for determining the neck status of early oral cancer patients. The concordance rate of intraoperative multislice frozen section analysis of SN and patient neck status at the time of operation was 95.6%. SN-positive patients exhibited a tendency toward cancer recurrence. There were three cases of false negatives not conforming to the SN concept and their rate was 7.9%. Positive SN had a negative impact on patient survival.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 93%

Follow-up after intraoperative sentinel node biopsy of N0 neck oral cancer patients

Terada

Hasegawa

Yatabe

et al. 2010

Eur Arch Otorhinolaryngol

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“…Some recommend that SNLB be performed in all patients with head and neck tumors thicker than 0.75 mm [Patel et al, 2002], and indeed some studies have shown superior results. Gomez-Rivera and colleagues reported a success rate of SLNB in head and neck melanomas of 96% [Gomez-Rivera et al, 2008]. In another series of 106 patients, SLNs were identified in 89% of patients [Teltzrow et al, 2007].…”

Section: Slnb For Head and Neck Melanomasmentioning

confidence: 96%

Challenging Problems in the Surgical Management of Melanoma

Ganapathi¹,

Tyler²,

Mosca³

2011

Current Management of Malignant Melanoma

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“…Approximately 15%-35% of primary cutaneous melanomas occur in head and neck (1). Head and neck melanoma (HNM) is more frequent in adult males and the most common affected sites are face, neck and ear.…”

Section: Introductionmentioning

confidence: 99%

Sentinel lymph node biopsy in head and neck melanoma

Giudice¹

2014

gchir

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Sentinel node biopsy in patients with cutaneous melanoma of the head and neck: Recurrence and survival study

Abstract: Primary tumor thickness and age were associated with decreased survival, whereas SLN status showed a trend for prognostic significance in CMHN.

Cited by 58 publications

References 35 publications

Follow-up after intraoperative sentinel node biopsy of N0 neck oral cancer patients

Follow-up after intraoperative sentinel node biopsy of N0 neck oral cancer patients

Challenging Problems in the Surgical Management of Melanoma

Sentinel lymph node biopsy in head and neck melanoma

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