2023
DOI: 10.3201/eid2902.221482
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Sentinel Surveillance System Implementation and Evaluation for SARS-CoV-2 Genomic Data, Washington, USA, 2020–2021

Abstract: Genomic data provides useful information for public health practice, particularly when combined with epidemiologic data. However, sampling bias is a concern because inferences from nonrandom data can be misleading. In March 2021, the Washington State Department of Health, USA, partnered with submitting and sequencing laboratories to establish sentinel surveillance for SARS-CoV-2 genomic data. We analyzed available genomic and epidemiologic data during presentinel and sentinel periods to assess representativene… Show more

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Cited by 8 publications
(9 citation statements)
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“…Our dataset included knockouts under a wide potential array of selection pressures, including knockouts which primarily spread locally and knockouts in the Alpha and XBB.1 descendant viruses which spread globally. As the first U.S. state to detect community transmission of SARS-CoV-2, WA has robustly sequenced COVID-19 cases throughout the pandemic aided by a sentinel surveillance sequencing system for geographic coverage 46 48 . From April 2021 through March 2023, 17.25% of all COVID-19 infections in WA were sequenced, with the lowest sequencing coverage in December 2021 (3% of cases) and the highest in February 2022 (28% of cases).…”
Section: Resultsmentioning
confidence: 99%
“…Our dataset included knockouts under a wide potential array of selection pressures, including knockouts which primarily spread locally and knockouts in the Alpha and XBB.1 descendant viruses which spread globally. As the first U.S. state to detect community transmission of SARS-CoV-2, WA has robustly sequenced COVID-19 cases throughout the pandemic aided by a sentinel surveillance sequencing system for geographic coverage 46 48 . From April 2021 through March 2023, 17.25% of all COVID-19 infections in WA were sequenced, with the lowest sequencing coverage in December 2021 (3% of cases) and the highest in February 2022 (28% of cases).…”
Section: Resultsmentioning
confidence: 99%
“…To implement this approach, it is necessary to ensure that viruses in the sample population re ect the genetic diversity of the original population. Sentinel surveillance of SARS-CoV-2 genomic data has provided more epidemiologically representative data [29] , earlier reports of variant shifts [30] and identi cation of novel imported variants [31] than those of conventional systems. The available data from the SBCVIC were more representative of the seventh COVID-19 epidemic wave in Japan than the o cial surveillance during the same period.…”
Section: Discussionmentioning
confidence: 99%
“…Implementing a nationwide surveillance system could have facilitated the early detection of the BA.5 outbreak in seventh wave and subsequent epidemic. A well-designed genome-based sentinel surveillance is more effective at detecting genomic data than a comprehensive reporting system [29] .…”
Section: Discussionmentioning
confidence: 99%
“…One key tool for understanding transmission dynamics in-place is pathogen genomic sequencing and analysis, particularly phylogeographic analysis. Understanding sampling methodology is important for describing potential bias in this type of analysis [ 9 – 11 ]. Systems for sequencing SARS-CoV-2 specimens have changed over time.…”
Section: Introductionmentioning
confidence: 99%
“…Prior to March 2021, sampling for sequencing from WA residents was convenience- or research-based. In March 2021, a sentinel surveillance system was implemented in WA to support representative sampling [ 9 ]. The population of WA LTCF-associated cases with genomic data available is as-yet undescribed.…”
Section: Introductionmentioning
confidence: 99%