Senyawa Damara-20,24-dien-3-on yang beraktivitas Sitotoksis terhadap Sel Mcf-7 dari Kulit Batang Chisocheton Marcrophyllus (Meliaceae)

Abstract

AbstrakSenyawa triterpenoid damaran, damara-20,24-dien-3-on telah diisolasi dari kulit batang Chisocheton Marcrophyllus (Meliaceae). Struktur kimia kedua senyawa tersebut telah ditetapkan berdasarkan data spektroskopi dan perbandingan data spektra yang diperoleh dari literatur. Senyawa damara-20,24-dien-3-on menunjukkan aktivitas sitotoksik terhadap sel kanker payudara manusia MCF-7 dengan nilai IC50 28 mM.Kata Kunci : aktivitas sitotoksik, sel MCF-7, triterpenoid damaran, Chisocheton Marcrophyllus, MeliaceaeAbstractDammarane triterpenoid, damara-20,24-dien-3-on has been isolated from the bark of Chisocheton Marcrophyllus (Meliaceae). Chemical Structure of compound was dtermined on the basic of spektroscopic data and comparison with those spectra data previously reported. Compound damara-20,24-dien-3-on exhibited cytotoxic activity againts MCF-7 human breast cancer cell lines with IC50 value 28 mM respectively.Kata Kunci : cytotoxic activity, MCF-7 cell, dammarane triterpenoid, Chisocheton Marcrophyllus, Meliaceae

Nimonol from Chisocheton macrophyllus (Meliaceae) Seeds and Their Cytotoxic Activity against P-388 Leukaemia Cells

“…In a previous study of the Chisocheton genus, the highest number of limonoids and triterpenoids were found (Shilpi et al, 2016;Najmuldeen et al, 2012;Supratman et al, 2020;Nurlelasari et al, 2021;Nurlelasari et al, 2015), then steroid, phenolic (Hidayat et al, 2018) and spermidine alkaloids (Nguyen et al, 2020).…”

“…In the leaves of C. macrophyllus (Meliaceae), it was reported that a new triterpenoid was found namely, 24hydroxydammara-20,25-dien-3-one, and three known triterpenoid compounds, namely moronic acid, oleanolic acid, and betulonic acid which had antitumor activity (Inada et al, 1993), in the seeds of C. macrophyllus one new limonoid (disobinol) and three known limonoid compounds (disobinin, nimonol, and 7α-hydroxyneotricilenon) were isolated (Nurlelasari et al, 2017;Rahmayanti et al, 2021 andNurlelasari et al, 2021) triterpenoids (Nurlelasari et al, 2015), and phenolic compounds have been found (Katja et al, 2015). This paper will describe the elucidation of the structure of nimonol, a limonoid that was first discovered in C. macrophyllus seeds.…”