Separable evoked retinal and cortical potentials from each major visual pathway: preliminary results.

Berninger, Thomas; Arden, G B; Hogg, Chris; Frumkes, Thomas E.

doi:10.1136/bjo.73.7.502

Cited by 93 publications

(64 citation statements)

References 34 publications

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“…The present results are in agreement with previous published literature showing that it is possible to isolate chromatic components of the cortical response by using isoluminant gratings and the appropriate procedures to maximize chromatic response and minimize achromatic intrusion~Carden et al, 1985;Murray et al, 1987;Berninger et al, 1989;Crognale et al, 1993;Rabin et al, 1994;Kulikowski et al, 1997;Porciatti & Sartucci, 1999;Suttle & Harding, 1999;Gomes et al, 2006 Tobimatsu et al, 1995;Porciatti & Sartucci, 1999;Gomes et al, 2006! demonstrated that it is possible to evaluate color discrimination thresholds both in dichromats and normal trichromats by using transient VEP and measuring the N1 peakto-baseline amplitude, and that this procedure shows a good correlation with psychophysical measurements.…”

Section: Transient Onset/offset Vepssupporting

confidence: 93%

Color discrimination ellipses of trichromats measured with transient and steady state visual evoked potentials

et al. 2008

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The purpose of this work is to investigate the use of different forms of visual evoked potentials (VEPs) to measure color discrimination thresholds and to plot color discrimination ellipses (MacAdam, 1942). Five normal trichromats (24.5 +/- 2.6 years-old) were monocularly tested. Stimuli consisted of sinusoidal isoluminant chromatic gratings made from chromaticity pairs located along four different color directions radiating from one reference point of the CIE 1976 chromaticity diagram (u' = 0.225; v' = 0.415). Heterochromatic flicker photometry (HFP) was used to obtain the isoluminance condition for every subject and for all chromaticity pairs. VEPs were elicited using two cycles per degree grating stimuli at three different temporal configurations: transient, onset (300 ms)/offset (700 ms), 1 Hz fundamental frequency; steady-state, onset (50 ms)/offset (50 ms), 10 Hz fundamental frequency; and steady-state pattern reversal at 5 Hz fundamental frequency (10 Hz phase reversal). VEP amplitude was measured using transient VEP N1-P1 components and steady state VEP first (10 Hz) and second (20 Hz) harmonics. VEP amplitude was plotted as a function of chromatic distance in the CIE 1976 color space and the data points were extrapolated to zero amplitude level to obtain chromatic discrimination thresholds. The results were compared with psychophysical measurements performed using the same stimulus configurations and with the pseudoisochromatic method of Mollon-Reffin (one-way ANOVA). For all subjects and all stimulation methods, the ellipses showed small sizes, low ellipticities, and were vertically oriented. Despite some consistent differences in the results obtained with different procedures, there was no statistical difference between ellipses obtained electrophysiologically and psychophysically. For steady state VEPs, ellipses obtained from second harmonic amplitudes were larger and more elongated in the tritan direction than those obtained with first harmonic amplitudes.

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Section: Transient Onset/offset Vepssupporting

confidence: 93%

Color discrimination ellipses of trichromats measured with transient and steady state visual evoked potentials

et al. 2008

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“…This could only be excluded by optimizing the chromatic stimulation for every individual by, for instance, the minimum-motion method [32], which is time-consuming and difficult to realize during clinical routine. Nevertheless, all BY-VEP curves showed a substantial negative peak between 110 and 220 ms, typical for isoluminant chromatic stimulation [33]. Consequently, we believe that an unimpaired application of this method in a clinical setting might only be feasible in pseudophakic patients.…”

Section: Discussionmentioning

confidence: 92%

Blue–yellow and standard pattern visual evoked potentials in phakic and pseudophakic glaucoma patients and controls

Fuest

Kieckhoefel

Mazinani

et al. 2015

Graefes Arch Clin Exp Ophthalmol

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“…More precise analyses of the PERG show that it consists of two components. PI is suggested to be partly generated by retinal ganglion cells, whereas the second negative wave N2 is associated with optic nerve activity, although both components are generated from the in ner retina [13], There is a report that PERG is produced by larger diameter retinal ganglion cells [14] which are damaged in the earlier stage of glaucoma [15], Combined abnormal ities of PI and N2 are also described in glauco matous eyes [13]. Recently, increasing atten tion has been paid to the N2 wave of glaucoma or OHT patients [16][17][18][19], It is not clear, how ever, at what stage of glaucoma or OHT the PERG abnormalities emerge.…”

Section: Introductionmentioning

confidence: 99%

A 3-Year Follow-Up Study of Ocular Hypertension by Pattern Electroretinogram

Arai¹,

Yoshimura²,

Sakaue³

et al. 1993

Ophthalmologica

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A 3-year following-up study of the pattern electroretinogram (PERG) was performed in 15 eyes of 8 ocular hypertensive (OHT) patients. At first PERG recording, the amplitude of the first positive wave P1 was statistically significantly reduced in the OHT patients compared with age-matched controls (p < 0.05). There was no difference in the amplitude of the second negative wave N2 (p > 0.05). At 40 months, the amplitude of both P1 and N2 decreased and the latency of P1 was elongated. Among the changes, the decrease in N2 amplitude was the most drastic (p = 0.0001 compared with the control, p < 0.05, compared with the first recording). Glaucomatous visual field defects developed 5 years after the first PERG recording and 2 years after the reduction in N2 amplitude in 1 patient. Decreased N2 amplitude of the PERG may be an important warning sign predicting the development of glaucoma in OHT patients.

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Separable evoked retinal and cortical potentials from each major visual pathway: preliminary results.

Cited by 93 publications

References 34 publications

Color discrimination ellipses of trichromats measured with transient and steady state visual evoked potentials

Color discrimination ellipses of trichromats measured with transient and steady state visual evoked potentials

Blue–yellow and standard pattern visual evoked potentials in phakic and pseudophakic glaucoma patients and controls

A 3-Year Follow-Up Study of Ocular Hypertension by Pattern Electroretinogram

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