Separate and Joint Associations of Shift Work and Sleep Quality with Lipids

Abstract

BackgroundShift work and/or sleep quality may affect health. We investigated whether shift work and sleep quality, separately and jointly, were associated with abnormal levels of triglycerides, total cholesterol (TC), and low-and high-density lipoprotein cholesterol in 360 police officers (27.5% women).MethodsTriglycerides, TC, and high-density lipoprotein were analyzed on the Abbott Architect; low-density lipoprotein was calculated. Shift work was assessed using City of Buffalo payroll work history records. Sleep quality (good, ≤ 5; intermediate, 6–8; poor, ≥ 9) was assessed using the Pittsburgh Sleep Quality Index questionnaire. A shift work + sleep quality variable was created: day plus good sleep; day plus poor sleep; afternoon/night plus good; and poor sleep quality. Mean values of lipid biomarkers were compared across categories of the exposures using analysis of variance/analysis of covariance.ResultsShift work was not significantly associated with lipids. However, as sleep quality worsened, mean levels of triglycerides and TC gradually increased but only among female officers (age- and race-adjusted p = 0.013 and 0.030, respectively). Age significantly modified the association between sleep quality and TC. Among officers ≥ 40 years old, those reporting poor sleep quality had a significantly higher mean level of TC (202.9 ± 3.7 mg/dL) compared with those reporting good sleep quality (190.6 ± 4.0 mg/dL) (gender- and race-adjusted p = 0.010). Female officers who worked the day shift and also reported good sleep quality had the lowest mean level of TC compared with women in the other three categories (p = 0.014).ConclusionSleep quality and its combined influence with shift work may play a role in the alteration of some lipid measures.

Shift work, and particularly permanent night shifts, promote dyslipidaemia: A systematic review and meta-analysis

“…We included 46 studies [10,17,23,24,37,38,40,41,43,45,[47][48][49][50][51][52][53][54][55][56][57][58][59]62,[65][66][67][68][69][70][71][73][74][75][76][77][78][79][80][81][82][83][84][85][86]91]. The overall SMD was − 0.08 (95CI − 0.12 to − 0.03; p = 0.001) with an important heterogeneity (I 2 = 85.9%) ( Fig.…”

“…2 and Supplementary Data 9). Among the 46 included studies, 6 studies reported permanent night shift [41,58,67,69,71,82] 43,45,49,62,67,68,75,79,81,84]. We found a significantly lower blood level of c-HDL among permanent night shift workers (SMD = − 0.16; 95CI − 0.32 to 0.00; p = 0.05; I 2 = 72.3%), rotating 3 × 8 shift workers (− 0.10; 95CI − 0.17 to − 0.02; p = 0.018; I 2 = 78.8%), and non-specified shift workers (− 0.08; 95CI − 0.15 to − 0.01; p = 0.027; I 2 = 81.7%).…”

Prevalence of Metabolic Syndrome in Military Police Officers of São Paulo City: The Health Promotion in Military Police (HPMP) Study

“…prevalence of MetS in MPO with ≥10 years at the PMESP. These findings suggest that the job characteristics of police officers, including excessive work hours, restricted night sleep due to the shift work schedule, potential and unexpected stressor situations (Charles et al, 2016;de Souza et al, 2018;Esquirol et al, 2009;Violanti et al, 2017), and low physical activity during work (Porto et al, 2020 unpublished data) contribute to the development of MetS. It is also important to point out that aging per se also plays an essential role in MetS development because there is a high occurrence of chronic diseases in the aged population (Schmidt et al, 2011).…”

Effect of night shift on development of metabolic syndrome among health care workers

“…Studies have shown high levels of TG more prevalent in night shift workers with no difference in serum HDL level. [ 18 ] Sleep quality and its influence in shift work play a role in the alteration of some lipid parameters[ 19 ] But some studies found no such difference for triglyceride and HDL between day and night shift work. [ 20 ] Lipid metabolism is susceptible to the effects of irregular shift work schedules and deranged sleep.…”