In this paper, a liquid multi-parameter decoupling method with only one Lamb wave sensor is presented. In a Lamb wave sensor, antisymmetric modes (A01 mode for low frequency, A03 mode for high frequency) and symmetric modes (S0 mode) are used to detect multiple parameters of a liquid, such as its density, sound velocity, and viscosity. We found they can play very different roles in the detections. For example, the A01 mode is very sensitive to the liquid's density but the A03 mode is sensitive to the sound velocity. Here, the A0 mode is used to identify the density of the detected liquid and with this density value we obtained the viscosity by the amplitude shifts of the S0 mode. This could be a way to distinguish an unknown liquid with high sensitivity or to solve the problem of selectivity of label-free detection on biosensors.