Separation and quantitative determination of acecarbromal, carbromal, and bromisoval as well as their main metabolites by means of high-pressure liquid chromatographic analysis

Abstract

A method is described to separate and quantitatively determine bromoureides and their bromo- and non-bromo-metabolites by means of high-pressure liquid chromatography. This method allows simultaneous measurement of these substances after intake of therapeutic as well as toxic doses.