Separation of amnion from choriodecidua is an integral event to the rupture of normal term fetal membranes and constitutes a significant component of the work required

Arikat, Sunny; Novince, Ryan W.; Mercer, Brian M.; Kumar, Deepak; Fox, Jennifer M.; Mansour, Joseph M.; Moore, John J.

doi:10.1016/j.ajog.2005.06.083

Cited by 77 publications

(90 citation statements)

References 15 publications

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“…* in shear along the uterine wall from preterm contractions and/or by partial delamination of the chorionic layer from the amnion or the decidua 6 * by membrane prolapse along the cervical inner canal 6Separation of amnion from choriodecidua might be integral part of the normal event sequence resulting in membrane rupture at term, as suggested by a study published this month [32].…”

Section: Etiologymentioning

confidence: 86%

Biomechanics of the human chorioamnion

Prevost¹,

Suresh²,

House³

et al. 2006

Journal of Biomechanics

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The human fetal membrane, namely the chorioamnion, is the structural soft tissue retaining the amniotic fluid and the fetus during pregnancy. Its biomechanical integrity is crucial for maintaining a healthy gestation and a successful delivery. The premature rupture of the fetal membrane (PROM) can result in serious perinatal complications. Despite extensive research in this field, the mechanical and biochemical processes governing the membrane deformation and failure remain poorly understood. The aim of this study is to characterize the mechanical behavior of the chorioamnionic tissue along with its biochemical properties, through mechanical testing and biochemical analyses. In order to accomplish this goal, specific mechanical and biochemical testing protocols were developed. In vitro mechanical testing was performed on samples from seven patients under different uniaxial and biaxial loading conditions. Significant relaxation was noted under uniaxial loading while very limited creep was observed under biaxial loading. Biochemical measurements such as collagen and sulfated glycosaminoglycan contents were also obtained. In addition, a microstructurally based constitutive model for the fetal membrane is proposed. The model allows for nonlinear hyperelastic response at large deformation. We also propose a framework to capture the timedependent response of the tissue. The model was implemented in a finite element formulation to allow three-dimensional simulations of membrane deformation.

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Section: Etiologymentioning

confidence: 86%

Biomechanics of the human chorioamnion

Prevost¹,

Suresh²,

House³

et al. 2006

Journal of Biomechanics

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“…In addition to its essential physiological function, it was also proposed as a promising candidate to be used as scaffold material for tissue engineering applications [10,11]. The mechanical response of the intact FM and of the separated amnion was investigated in uniaxial tensile tests [7,12,13,14,15,16,17,18], biaxial tensile tests [16,19], puncture tests [9,17,20,21,22,23,24] and inflation tests [3,25,26,27,28,29,30,31]. These studies focused primarily on the quasi-static monotonic deformation and rupture behavior, with only a few works investigating the time-dependent response of the intact membrane [26,28,29] or of the amnion alone [15,16,32].…”

Section: Introductionmentioning

confidence: 99%

Time-dependent mechanical behavior of human amnion: Macroscopic and microscopic characterization

et al. 2015

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Edoardo (2015) Time-dependent mechanical behavior of human amnion: Macroscopic and microscopic characterization. Acta Biomaterialia, 11 . pp. 314-323. ISSN 1878-7568 Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/45411/1/mauri_actabiomaterialia2014_preprint.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the Creative Commons Attribution Non-commercial No Derivatives licence and may be reused according to the conditions of the licence. For more details see: http://creativecommons.org/licenses/by-nc-nd/2.5/ A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. AbstractCharacterizing the mechanical response of the human amnion is essential to understand and to eventually prevent premature rupture of fetal membranes. In this study, a large set of macroscopic and microscopic mechanical tests has been carried out on fresh unfixed amnion to gain insight into the time-dependent material response and the underlying mechanisms. Creep and relaxation responses of amnion were characterized in macroscopic uniaxial tension, biaxial tension and inflation configurations. For the first time, these experiments were complemented by microstructural information from nonlinear laser scanning microscopy performed during in-situ uniaxial relaxation tests. The amnion showed large tension reduction during relaxation and small inelastic strain accumulation in creep. The short-term relaxation response was related to a concomitant in-plane and out-of-plane contraction and was dependent on the testing configuration. The microscopic 2 investigation revealed a large volume reduction at the beginning, but no change of volume was measured long-term during relaxation. Tension-strain curves normalized with respect to the maximum strain were highly repeatable in all configurations and allowed the quantification of corresponding characteristic parameters. The present data indicate that dissipative behavior of human amnion is related to two mechanisms: (i) volume reduction due to water outflow (up to ~20 seconds) and (ii) long-term dissipative behavior without macroscopic deformation and no systematic global reorientation of collagen fibers. IntroductionThe fetal membrane (FM) surrounds the growing fetus and ensures its environment during gestation. Preterm premature rupture of the membrane affects about 3% of all pregnancies and increases the risk of morbidity in the newborn [1]. The etiology of preterm premature rupture of the membrane is complex and not completely understood. Repeated mechanical loading, such as that occurring as a result of fetal movement and labor, was recen...

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“…Fe tal mem bra nes be co me signi fi cantly we a ker as a re sult of this se pa ra ti on. 29,30 I In n c co on nc c l lu u s si i o on n; ; in this study, no sig ni fi cant diffe ren ce in the col la gen con tent was de mons tra ted bet we en the PPROM gro up and the con trol gro up. Mo re o ver, no sig ni fi cant dif fe ren ce was ob ser ved in the col la gen con tent bet we en the thre e re gi ons in the PPROM gro up.…”

Section: Discussionmentioning

confidence: 75%

Amniotic Membrane’s Hydroxyproline Content and Preterm Premature Rupture of Membranes

Saglam¹,

Derwig²,

Kasap³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S TTR RA AC CT T O Ob b j je ec c t ti i v ve e: : To de ter mi ne whet her pre term pre ma tu re rup tu re of the mem bra nes (PPROM) is ca u sed by a ge ne ra li sed and/or lo ca li sed re duc ti on in the hydroxy pro li ne con tent of the am ni o tic mem bra ne. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : This study inc lu ded 105 par tu ri ent wo men who de li vered bet we en Sep tem ber 2005-March 2006 in Ze ka i Ta hir Bu rak Wo men's He alth Edu ca ti on and Rese arch Hos pi tal High Risk Preg nancy De part ment. The first gro up inc lu ded 40 par tu ri ent wo men with PPROM. The se cond gro up inc lu ded 65 par tu ri ent wo men with in tact mem bra nes ha ving an elec tive Ca e sa re an sec ti on with the di ag no sis of pre vi o us ca e sa re an sec ti on. In the PPROM gro up (n= 40), 25 wo men de li ve red va gi nally and 15 wo men had an emer gency Ca e sa re an sec ti on for fe tal dis tress at the be gin ning of la bo ur. The hydroxy pro li ne con tent of the amniotic membranes of 40 wo men with pre term pre ma tu re rup tu re of the mem bra nes was com pa red with these of 65 wo men who deli ve red by elec ti ve Ca e sa re an sec ti on. Thre e re gi ons of the am ni o tic mem bra ne we re exa mi ned: 1) the rup tu re si te 2) the mid zo ne are a, which was the half way bet we en the rup tu re site and pla cen tal ed ge; and 3) pe rip la cen tal are a, which was usu ally 10-12 cm away from the rup tu re si te. R Re e s su ul lt ts s: : In the rup tu re si te, no sig ni fi cant dif fe ren ce was de tec ted in the hydroxy pro li ne con tent bet we en the con trol gro up (0.17-0.63 mg/mg pro te in) and the PPROM gro up (0.26-0.51mg/mg pro te in) (p= 0.916). In the mid zo ne are a, the re was no sig ni fi cant dif fe ren ce bet we en the con trol gro up (0.16-1.45 mg/mg pro te in) and the PPROM gro up (0.24-0.84 mg/mg pro te in) (p= 0.462). In the pe rip la cen tal are a the re was no sig ni fi cant dif fe ren ce bet we en the con trol gro up (0.23-1.35 mg/mg pro te in) and the PPROM gro up (0.23-1.13 mg/mg pro te in) (p= 0.753). C Co on nc c l lu u s si i o on n: : Pre term pre ma tu re rup tu re of the mem branes do es not ap pe ar to be ac com pa ni ed by a ge ne ra li sed or lo ca li sed re duc ti on in the collagen of amni o tic mem bra ne. K Ke ey y W Wo or rd ds s: : Fe tal mem bra nes, pre ma tu re rup tu re; hydroxy pro li ne; am ni o tic mem bra ne Ö ÖZ ZE ET T A Am ma aç ç: : Pre term er ken mem bran rüp tü rü nün (PEMR) am ni on za rı nın hid rok sip ro lin içe ri ğin -de ki yay gın ve ya lo ka li ze azal ma sın dan kay nak la nıp kay nak lan ma dı ğı nı be lir le mek. G Ge e r re eç ç v ve e Y Yö ön n t te em m --l le er r: : Ça lış ma ya Ze ka i Ta hir Bu rak Ka dın Sağ lı ğı Eği tim ve Araş tır ma Has ta ne si Yük sek Risk li Ge be lik Bö lü mü'n de Ey lül 2005-Mart 2006 ara sın da do ğum ya pan 105 ka dın alın dı. İlk grup PEMR si olan 40 ka dı nı kap sı yor du. İkin ci grup ta da ha ön ce se zar yen ge çir me öy kü sü ol du ğu için elek tif se zar ye ne alı -...

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Separation of amnion from choriodecidua is an integral event to the rupture of normal term fetal membranes and constitutes a significant component of the work required

Cited by 77 publications

References 15 publications

Biomechanics of the human chorioamnion

Biomechanics of the human chorioamnion

Time-dependent mechanical behavior of human amnion: Macroscopic and microscopic characterization

Amniotic Membrane’s Hydroxyproline Content and Preterm Premature Rupture of Membranes

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