Separation of dansyl-dl-amino acids by open tubular capillary chromatography based on tube radial distribution phenomenon of the ternary mixed carrier solvents

Fundamental Research and Application of the Specific Fluidic Behavior of Mixed Solvents in a Microspace

“…[46][47][48][49][50][51][52][53] Some systems employed coated capillary tubes, 47 and others included additives. 26,27,54 As exemplified, the separation of biomolecules, such as isoluminol isothiocyanate (ILITC)-labeled glutamic acid (Glu), ILITC-labeled alcohol dehydrogenase from yeast (ADH), and ILITC-labeled bovine serum albumin (BSA), were investigated using the TRDC system with a chemiluminescence detector (Fig. 6).…”

“…Such a system is referred to as tube radial distribution chromatography (TRDC). [25][26][27] We have also applied TRDP for extraction, 28,29 chemical reaction, 30,31 and mixing processes. 32 The respective TRDP-based processes are coined as tube radial distribution extraction (TRDE), tube radial distribution reaction (TRDR), and tube radial distribution mixing (TRDM).…”

Tube Radial Distribution of Solvents Observed in an Aqueous Ionic Liquid Mixed Solution Delivered into a Capillary Tube

“…The formation of inner and outer phases in a capillary tube was changed by the composition ratios of the IL and the salt in the aqueous solution. The previous TRDP using ternary mixed solvents of water-hydrophilic/hydrophobic organic mixtures have been examined from the viewpoints of chromatography, 4 extraction, 5 micro-reaction, 6 and mixing process. 7 The new type of TRDP with the aqueous IL mixed solution will lead to further developments of both fundamentals and applications of TRDP and related technologies.…”

“…The interface forms radially with the same linear velocity in a capillary tube. We investigated TRDP in chromatography, 4 extraction, 5 chemical reaction, 6 and mixing process. 7 Since the last century, phase separation in aqueous two-phase systems of ionic liquids (ILs) has been well known in the field of analytical chemistry and separation science.…”

Two-Phase Extraction of Metal Ions Using a Water-Acetonitrile-Ethyl Acetate Ternary Mixed-Solvent Separation System

“…[18][19][20] A ternary mixed solvent solution of water-hydrophilic/hydrophobic solvents changes from a homogeneous (single-phase) to a heterogeneous (two-phase) system with temperature and/or pressure changes. This phenomenon causes a specific fluidic behavior in a microspace, such as a microchannel on a microchip or a capillary tube, leading to new types of open-tubular capillary chromatography 21 and microreactors. 22 In this study, for the first time we have used a two-phase separation system comprising a ternary mixed-solvent solution in a batch vessel to extract metal ions.…”