Separation of flavonoids and phenolic acids in complex natural products by microemulsion electrokinetic chromatography using surfactant‐coated and carboxylic single‐wall carbon nanotubes as additives

Cao, Jun; Qu, Haibin; Cheng, Yiyu

doi:10.1002/elps.200900696

Cited by 39 publications

(37 citation statements)

References 32 publications

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“…CSPs have been mainly used for the enantiomeric separation of flavanones (Yañez et al, 2007), although chiral HPLC has been also applied for the separation of catechin diastereomers (Rinaldo et al, 2010) or taxifolin enantiomers (Vega-Villa et al, 2009). Chiral additives have been used to separate flavonoid enantiomers mainly by capillary electrophoresis (Cao, Qu, and Cheng, 2010;Kwon and Jung, 2011).…”

Section: Chiral Separationsmentioning

confidence: 99%

Strategies in the Analysis of Plant Flavonoids

Santos‐Buelga

Gonzaléz-Paramás

2014

Encyclopedia of Analytical Chemistry

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Flavonoids are one of the largest groups of plant secondary metabolites. They comprise several thousand compounds that share a phenylchromane skeleton and can be classified into different classes, namely flavones, flavonols, flavanones, flavanols, anthocyanins, dihydroflavonols, isoflavones, and chalcones. Flavonoids occur in their natural sources as aglycones or glycosylated forms and as monomers or constituting polymerized structures and can be found both as free and matrix‐bound compounds. This structural diversity affects their physicochemical behavior, and different flavonoid classes and compounds may have different requisites for their extraction and analysis, so that there is not a unique analytical strategy that applies in all situations. In this chapter, the main methodological approaches to the analysis of flavonoids in plant materials are revised paying particular attention to more recent extraction techniques and high performance liquid chromatography‐based methodologies that currently dominate the field of flavonoid analysis.

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Section: Chiral Separationsmentioning

confidence: 99%

Strategies in the Analysis of Plant Flavonoids

Santos‐Buelga

Gonzaléz-Paramás

2014

Encyclopedia of Analytical Chemistry

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“…Cao et al reported a novel addition of CNTs to an MEEKC buffer. CNTs are nano diameter sized cylindrical carbon molecules with a length of 300–2300 nm which can also form hydrophobic aggregates in solution and can therefore influence analyte partitioning within a CE capillary.…”

Section: Recent Applicationsmentioning

confidence: 99%

“…The CNTs can be added as single‐wall CNTs, surfactant‐coated single‐wall carbon nanotubes (SC‐SWNTs), multiwalled carbon nanotubes, and carboxylic single‐wall carbon nanotubes (C‐SWNTs). The study by Cao et al systematically examined the effect SC‐SWNTs and C‐SWNTs as additives to an MEEKC BGE for the determination of a range of flavonoids and phenolic acids.…”

Section: Recent Applicationsmentioning

confidence: 99%

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A review of developments in the methodology and application of microemulsion electrokinetic chromatography

Ryan

Altria

McEvoy³

et al. 2012

Electrophoresis

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MEEKC is a mode of CE, which utilizes microemulsion (ME) as the BGE to achieve separation of a diverse range of analytes. MEs are composed of nanometer-sized oil droplets suspended in aqueous buffer which are stabilized by the presence of a surfactant and co-surfactant. These MEs are commonly referred to as oil-in-water MEs and their application in MEEKC has been extensively examined. This review details advances in the theory, methodology, and application of MEEKC during the period 2010-2012. Areas covered include online sample concentration, advances in chiral separations, use of coated capillaries, chemometric approaches, and the use of novel additives to the ME system. This review also provides the reader with an introduction to MEEKC and a presentation of recent applications.

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“…These nanomaterials have been used wide variety of applications in analytical science . CNTs were used as SPE or adsorbents to determine environmental sample , used as carriers for CE , as additives to separate flavonoids and phenolic acids , in extraction procedures , in electrochemical analysis such as sensors , and membranes . Over the past decade, CNTs have been functionalized (i.e.…”

Section: Introductionmentioning

confidence: 99%

Capillary electrophoresis coupled to evaporative light scattering detection for direct determination of underivatized amino acids: Application to tea samples using carboxyled single‐walled carbon nanotubes for sample preparation

Bouri

Salghi²,

Zougagh

et al. 2013

Electrophoresis

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An improved and efficient method for the determination of underivatized amino acids based on the use of CE coupled to evaporative light scattering detector (ELSD), involving carbon nanotubes, was successfully developed. Carboxyled single-walled carbon nanotubes were used for the first time to perform the clean-up of the analyzed samples, which were afterwards analyzed by CE-ELSD. White tea samples were used to demonstrate the usefulness of the CE-ELSD coupled methodology. A suitable interface, based on a triple tube design sprayer, was developed and successfully used for coupling both instruments. Parameters affecting the separation and determination, including the elimination of interferences, were studied and properly optimized. Under the optimized conditions good resolution was achieved for the separation of seven amino acids. The precision of the method, expressed as RSD, was found within the 3.5-5.3% range. The LOD obtained for the proposed method were in the 1.2-2.1 pg range and the LOQ, were in the 2.0-11.5 pg range, with injection pressure of 5 KPa for 20 s (15.3 nL). This method is simple, rapid, and selective compared with other conventional techniques.

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Separation of flavonoids and phenolic acids in complex natural products by microemulsion electrokinetic chromatography using surfactant‐coated and carboxylic single‐wall carbon nanotubes as additives

Cited by 39 publications

References 32 publications

Strategies in the Analysis of Plant Flavonoids

Strategies in the Analysis of Plant Flavonoids

A review of developments in the methodology and application of microemulsion electrokinetic chromatography

Capillary electrophoresis coupled to evaporative light scattering detection for direct determination of underivatized amino acids: Application to tea samples using carboxyled single‐walled carbon nanotubes for sample preparation

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