Separation of four -lol drugs by HPLC with new bonded chiral stationary column

Zhou, Jie; Pei, Wenjuan; Su, Nan; Liu, Qian; Fu, Guangjun; Zhang, Zhenzhong

doi:10.1007/s11434-012-5636-7

Cited by 10 publications

(9 citation statements)

References 7 publications

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“…have been determinated in environmental or food samples (soil, natural waters, fruits, vegetables, etc.). Pharmaceutical compounds recognized as potential anti-carcinogen agents [44,45,56,92,64], α-and β-adrenergic receptor blockers [51,92,59,[65][66][67][68]60], nonsteroidal anti-inflammatory drugs [38], antihistamines [92,74], proton pump inhibitors [50,94,73,79,81,88,96,76], retroviral drugs [55,84], antihyperglycemic drugs [83], antihelminthic agents [40,57], anti-hypertensive drugs [41,53,85], L-type calcium channel [72,89], broad-spectrum antimicrobials [95,70], nootropic drugs [90,91], anticoagulant drugs [69], etc. have also been determined, especially in commercial products or biological samples (pharmaceutical formulations, human urine, human or animal blood, human plasma, animal serum, etc.).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

State-of-the-art and recent developments of immobilized polysaccharide-based chiral stationary phases for enantioseparations by high-performance liquid chromatography (2013–2017)

Padró

Keunchkarian

2018

Microchemical Journal

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Please cite this article as: Juan M. Padró, Sonia Keunchkarian , State-of-the-art and recent developments of immobilized polysaccharide-based chiral stationary phases for enantioseparations by high-performance liquid chromatography (2013)(2014)(2015)(2016)(2017). AbstractPolysaccharide-based chiral stationary phases have been recognized as one of the most powerful ones for high performance liquid chromatography (HPLC) separations of chiral compounds in analytical and also in preparative scale.Immobilized polysaccharide-based chiral stationary phases constitute a remarkable achievement due to their stable nature on working with standard or common solvents and also with those prohibited for using with coated phases.This review is mainly focused on the i. applications of these chiral stationary phases in numerous fields of HPLC separations; ii. comparative aspects between immobilized vs. coated polysaccharide-derived phases, and iii. revision of several theoretical studies such as enantiorecognition mechanism, mobile phase composition and column temperature effects.

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Section: Accepted Manuscriptmentioning

confidence: 99%

State-of-the-art and recent developments of immobilized polysaccharide-based chiral stationary phases for enantioseparations by high-performance liquid chromatography (2013–2017)

Padró

Keunchkarian

2018

Microchemical Journal

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“…[4,[16][17][18] And the enantiomers of bevantolol were separated by our laboratory in normal phase HPLC systems with Chiralpak IB column. [19] In the current study, the normal phase was replaced by reversed phase because of its lower toxicity and lower cost. In addition, Aboul-Enein et al [16] separated the enantiomers in reverse phases using a Chiralcel OD-R column (R s ¼ 1.00).…”

Section: Analytical Performancementioning

confidence: 99%

Chiral High-Performance Liquid Chromatographic Analysis of Bevantolol Hydrochloride

Zhou

Liu

et al. 2014

Journal of Liquid Chromatography & Related Technologies

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& A new liquid chromatographic method has been developed for the chiral separation of the enantiomers of bevantolol hydrochloride. The enantiomers were separated by a Chiralpak IB (250 Â 4.6 mm, 5 lm) with a binary solvent mixture of acetonitrile-20 mmol Á L À1 KH 2 PO 4 (25=75, v=v; pH 4.5)-at 25 C and detected at 259 nm, with a flow rate of 0.8 mL Á min À1 . The resolution was 3.90. The effects that organic modifier, type of buffer, mobile phase pH, column temperature, and flow rate had on the enantioselectivity of enantiomers were evaluated. And the structures of the enantiomers of bevantolol hydrochloride were determined.

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“…Some reports on the enantioseparation of β‐adrenergic blockers by using HPLC with CSP such as Chiralpak AD, Chiralpak IA, Chiralpak IB, and Chiralpak ID were published, but there are very few studies on enantioseparation of β‐adrenergic blockers with Chiralpak IC . As far as we know, four selected β‐adrenergic blockers mentioned in the article have not been reported to be chiral separated by Chiralpak IC column.…”

Section: Introductionmentioning

confidence: 99%

Enantioseparation and molecular modeling study of five β‐adrenergic blockers on Chiralpak IC column

Zhao

Wang

et al. 2019

Chirality

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A new high‐performance liquid chromatography (HPLC) method was developed for the enantiomeric resolution of five β‐adrenergic blockers on a Chiralpak IC column (250 mm × 4.6 mm, 5.0 μm particle size) in normal phase mode. The mobile phase used was n‐hexane‐ethanol‐diethylamine in different proportions at the flow rate of 1.0 mL/min with the column temperature of 25°C using a UV detector at 230 nm. The influences of base additives and alcohol modifiers were evaluated and optimized. The maximum resolution values for bevantolol, propranolol carteolol, esmolol, and metoprolol were 4.80, 2.77, 2.09, 2.30, and 1.11, respectively. To gain a better understanding of the interaction between chiral stationary phase and analyte enantiomers, the molecular docking of chiral stationary phase with five pairs of enantiomer was carried out using AutoDock molecular docking technique. By simulation studies, the mechanism of chiral recognition was determined. According to the results, hydrogen bond interactions and π‐π interactions were the chief interactions for the chiral recognition.

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Separation of four -lol drugs by HPLC with new bonded chiral stationary column

Cited by 10 publications

References 7 publications

State-of-the-art and recent developments of immobilized polysaccharide-based chiral stationary phases for enantioseparations by high-performance liquid chromatography (2013–2017)

State-of-the-art and recent developments of immobilized polysaccharide-based chiral stationary phases for enantioseparations by high-performance liquid chromatography (2013–2017)

Chiral High-Performance Liquid Chromatographic Analysis of Bevantolol Hydrochloride

Enantioseparation and molecular modeling study of five β‐adrenergic blockers on Chiralpak IC column

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