Separation of ibuprofen enantiomers by supercritical fluid simulated moving bed chromatography

Abstract

The continuous separation of R(2 )-ibuprofen and S(þ )-ibuprofen by supercritical fluid simulated moving bed chromatography has been developed. First, experiments were performed at a low concentration level. Therefore, a starting set of operating parameters was calculated using the "triangle theory," which has been developed in the frame of equilibrium theory. Subsequently, the feed concentration was increased. A dynamic simulation program, based on a plug flow model with axial dispersion and linear mass transfer resistance, was used to predict the effect of operating variables on the process performance. Adsorption isotherms were determined with the elution by a characteristic point method. The experimental results were compared both with the model predictions based on the triangle theory and with the results of simulations. 2545

Modeling of Simulated Moving‐bed Chromatography

“…Experimental results on the separation of tetralol by SMB-SFC in linear range were published by Denet et al [28]. The continuous separation of R(−)-ibuprofen and S(+)-ibuprofen by SMB-SFC has been developed by Peper et al [29]. An experimental productivity of 504 g racemate /kg sp d was obtained.…”

“…Chromatographic separations of phytol isomers, ibuprofen enantiomers, and tocopherol homologs by SMB-SFC have been performed experimentally and were further investigated by simulations [29,55,58,[65][66][67]. The apparatus for experimental separations by SMB-SFC as well as the methods and models for determination of the adsorption equilibrium as the basis for chromatography simulation have been described elsewhere [27,68].…”

“…Cubic Hill-adsorption isotherms dependent on pressure were determined for the ibuprofen enantiomers. The mixture interactions were taken into account by the IAST [29].…”

“…After optimization of the SMB-SFC process by simulation the specifi c productivity could be increased from 0.05 to 0.36 kg racemate /l SP d also experimentally while the consumption of CO 2 and 2-propanol referring to the injected racemate could be cut in half [29].…”

Separação cromatográfica quiral de anestésicos a partir de soluções diluídas e concentradas em escala preparativa

“…Essas incluem as fases baseadas em dialil-L-tartardiamida com ligações cruzadas (Kromasil CHI-DMB e Kromasil CHI-TBB) [14][15][16][17][18][19][20][21][22] e as fases baseadas em ciclodextrinas. 23,24 Embora ainda tenham sido pouco estudadas, as FEQ baseadas em dialil-L-tartardiamida têm apresentado, além de uma boa capacidade de saturação, um elevado número de pratos teóricos quando comparados com outras fases.…”